A case series of concomitant burn and COVID-19

Hesamirostami, Mohammadhossein; Nazarian, Roozbeh; Asghari, Hassan; Jafarirad, Abdolreza; Khosravi, Ali Reza; Nouranibaladezaei, Seyedehzahra; Radfar, Azar

doi:10.1016/j.burnso.2020.11.003

Cited by 7 publications

(7 citation statements)

References 16 publications

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“…These receptors are negative regulator of the renin angiotensin system involved in inflammation. 3 4 Therefore, COVID-19 infection in burns can, not only add to the latter’s morbidity and mortality but also necessitate the requirement of longer intensive care for such cases. Further, health-care workers involved in burn care are also at a heightened risk in comparison to the general COVID care staff, due to increased contact time with raw burn wounds while dressing and during respiratory care of patients with inhalational burns.…”

Section: Discussionmentioning

confidence: 99%

“…2 Burn patients are also physiologically immunocompromised, which adds to their vulnerability if they contract COVID-19 infection. 3,4 Alteration in the epidemiology of burns is expected during the COVID pandemic due to change in the pattern of daily activities. To improve the outcome of burns during this pandemic, we needed to evaluate the incidence, risk factors, and outcome of COVID infection in burn patients.…”

Section: Introductionmentioning

confidence: 99%

“… 2 Burn patients are also physiologically immunocompromised, which adds to their vulnerability if they contract COVID-19 infection. 3 4 …”

Section: Introductionmentioning

confidence: 99%

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Impact of COVID-19 on Patient Trends and Outcome: Results from a Tertiary Care Burn and Plastic Unit in Northern India

Aggarwal

Srivastava

2021

Indian J Plast Surg

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Background Burn and trauma injuries need emergency care and resuscitation, which required uninterrupted delivery of inpatient care services during the coronavirus disease 2019 (COVID-19) pandemic. Burn patients are physiologically immunocompromised, increasing the risk of COVID-19 infection in them. This study analyzes the impact of COVID-19 pandemic on patient trends in a burn and plastic unit and assesses the effect of COVID-19 infection in burns. Methods This single-center, retrospective observational case–control study was conducted in the Department of Burns, Plastic and Maxillofacial Surgery of a tertiary care hospital in New Delhi, India. Patient data was collected from April 1, 2019 to August 10, 2019 and from April 1, 2020 to August 10, 2020. All data of burns and trauma patients collected was analyzed and compared. Results There were total 350 admissions during COVID time period and 562 admissions during non-COVID time period. The admission rate, type of burn injury, and death rate did not vary significantly during the two time periods. Thermal burn was the most common type of burn injury. There were total 18 cases diagnosed to be COVID-19 positive during the pandemic. There were two deaths among COVID-19 positive burn cases. Conclusion This study finds no difference in patient patterns during COVID and non-COVID time period. Amongst burn patients, no increased risk of COVID-19 infection is seen with larger body surface area of burns. No increase in mortality is seen in burn patients infected with COVID-19.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of COVID-19 on Patient Trends and Outcome: Results from a Tertiary Care Burn and Plastic Unit in Northern India

Aggarwal

Srivastava

2021

Indian J Plast Surg

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“…In general, COVID-19 severe symptoms are more common in older patients with underlying cardiac, pulmonary, and metabolic disorders, notably those complicated by ARDS [ 23 ]. COVID-19, in turn, is a complicating factor for other critical diseases, such as burn injury and surgical complications [ 24 , 25 ].…”

Section: Systemic Reactions In Covid-19mentioning

confidence: 99%

Problems of Pathogenesis and Pathogenetic Therapy of COVID-19 from the Perspective of the General Theory of Pathological Systems (General Pathological Processes)

Гусев

Sarapultsev

et al. 2021

IJMS

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The COVID-19 pandemic examines not only the state of actual health care but also the state of fundamental medicine in various countries. Pro-inflammatory processes extend far beyond the classical concepts of inflammation. They manifest themselves in a variety of ways, beginning with extreme physiology, then allostasis at low-grade inflammation, and finally the shockogenic phenomenon of “inflammatory systemic microcirculation”. The pathogenetic core of critical situations, including COVID-19, is this phenomenon. Microcirculatory abnormalities, on the other hand, lie at the heart of a specific type of general pathological process known as systemic inflammation (SI). Systemic inflammatory response, cytokine release, cytokine storm, and thrombo-inflammatory syndrome are all terms that refer to different aspects of SI. As a result, the metabolic syndrome model does not adequately reflect the pathophysiology of persistent low-grade systemic inflammation (ChSLGI). Diseases associated with ChSLGI, on the other hand, are risk factors for a severe COVID-19 course. The review examines the role of hypoxia, metabolic dysfunction, scavenger receptors, and pattern-recognition receptors, as well as the processes of the hemophagocytic syndrome, in the systemic alteration and development of SI in COVID-19.

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“…Endothelial dysfunction is responsible for COVID-19-associated vascular inflammation and coagulopathy [45] . In a small cohort study involving COVID-19 patients, the augmented levels of IFN-α and IFN-stimulated gene (ISG) were linked with viral load and disease severity.…”

Section: Pathophysiology Of Covid-19 Induced Ardsmentioning

confidence: 99%

COVID-19-Associated acute respiratory distress syndrome (CARDS): Mechanistic insights on therapeutic intervention and emerging trends

Thapa

Verma

Singh

et al. 2021

International Immunopharmacology

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A case series of concomitant burn and COVID-19

Cited by 7 publications

References 16 publications

Impact of COVID-19 on Patient Trends and Outcome: Results from a Tertiary Care Burn and Plastic Unit in Northern India

Impact of COVID-19 on Patient Trends and Outcome: Results from a Tertiary Care Burn and Plastic Unit in Northern India

Problems of Pathogenesis and Pathogenetic Therapy of COVID-19 from the Perspective of the General Theory of Pathological Systems (General Pathological Processes)

COVID-19-Associated acute respiratory distress syndrome (CARDS): Mechanistic insights on therapeutic intervention and emerging trends

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