A Case Series of Clinically Undiagnosed Hematopoietic Neoplasms Discovered at Autopsy

Podduturi, Varsha; Guileyardo, Joseph M.; Soto, Luis R.; Krause, John R.

doi:10.1309/ajcpay9zis1xepro

Cited by 5 publications

(1 citation statement)

References 17 publications

(28 reference statements)

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“…However, less than 50% of sudden death cases actually receive autopsy [15]. Among those that do receive autopsy, findings of sarcoma have been reported [12][13][14] but are very unusual. Moreover, our results show that in most cases of sarcoma causing sudden death, the deceased did not have a medical history of sarcoma, meaning that scene investigation and questioning of family members alone may not provide sufficient information to determine COD.…”

Section: Discussionmentioning

confidence: 99%

Sudden Death Due to Sarcoma: An Unusual Case and Literature Review

Wy²,

Shun³

2016

Journal of Forensic Science & Criminology

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Background: Sudden death has varied causes, and autopsy is usually required to determine cause of death. Sarcoma involvement is very infrequent, and detailed pathological evaluation is needed for correct diagnosis. When the medical history of the deceased is unavailable and autopsy is not performed, the true cause of death will not be established. Here we present an unusual case of sarcoma involving heart and lung. We also review 13 cases found in the literature with sarcoma involvement in sudden death. , which makes it more difficult to collect pertinent evidence and information. In such cases, forensic autopsy is usually performed; it is also usually required in order to gain any information. Even with autopsy, however, a small proportion of cases will not reveal a cause of death (COD). In these cases, the COD is categorized as "sudden unexplained death" [5,6]. Introduction Sudden ISSN: 2348-9804Results: The current case was a 58-year-old man found dead at home with a history of sarcoma and wide excision. The autopsy showed multiple tumors involving heart and lung. Microscopic findings showed a spindle cell tumor with prominent nuclear pleomorphism. Immunohistochemical studies revealed that the tumor cells were positive for vimentin only. Further analysis, combining the current case with 13 cases from the literature, showed no specific grading or types of sarcoma associated with sudden death. Six of the 14 cases were younger than 1 year old. Ten cases did not have a history of sarcoma prior to death, and 7 of these 10 cases had primary sarcoma sites in vital organs. In the 4 cases with sarcoma history, only 1 case showed a primary site developing in a vital organ. However, the differences in history between these groups were not significant (p = .145). Conclusion:No types or grading of sarcoma were found to be associated with sudden death. The cases without a prior medical history of sarcoma, compared to the cases with a sarcoma history, seemed to have primary sites in vital organs, but the results were not statistically significant. More studies are needed to clarify the relationship between the history and primary site of sarcoma and sudden death.

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Section: Discussionmentioning

confidence: 99%

Sudden Death Due to Sarcoma: An Unusual Case and Literature Review

Wy²,

Shun³

2016

Journal of Forensic Science & Criminology

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Lymphoma in autopsy cases

Alkhasawneh

Mubeen

Gopinath

2018

Forensic Sci Med Pathol

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Lymphoproliferative disorders cause significant morbidity and mortality, either related to the disease itself or therapy complications. Some cases of lymphoma may have vague clinical presentation, especially in the absence of lymphadenopathy, and a clinical work up may not be conclusive. Our study focuses on autopsy cases of lymphoma patients, emphasizing clinically unsuspected cases. Autopsy records from the last 20 years at our institution were searched, and the clinical parameters were recorded. Fifteen cases of lymphoma were identified, and 5 cases were diagnosed at the time of autopsy. Most B-cell lymphoma cases were mainly nodal disease, while T-cell lymphoma cases had widespread extra-nodal disease. Most deaths in B-cell lymphoma are due to infection/therapy induced immunosuppression, whereas T-cell lymphoma deaths are due to organ infiltration by lymphoma. Postmortem examination may reveal clinically unsuspected lymphoma, especially in rapidly deteriorating patients with vague presentation such as skin rash, bowel obstruction/bleeding or pacemaker malfunction.

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Hematopoietic System

2016

Diagnostic Pathology: Hospital Autopsy

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A Case Series of Clinically Undiagnosed Hematopoietic Neoplasms Discovered at Autopsy

Cited by 5 publications

References 17 publications

Sudden Death Due to Sarcoma: An Unusual Case and Literature Review

Sudden Death Due to Sarcoma: An Unusual Case and Literature Review

Lymphoma in autopsy cases

Hematopoietic System

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