A Case Report on Parvovirus B19 Associated Myositis

Oliver, Nathan D.; Millar, Auleen; Pendleton, Adrian

doi:10.1155/2012/250537

Cited by 11 publications

(9 citation statements)

References 4 publications

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“…Gangrene of stomach or intestine owing to non-occlusive bowel infarction (NOBI) has an unknown aetiology 8 9 10 11 with no further information after our report 5 , and same is the status for amegakaryocytic thrombocytopenia due to B19 infection. However, there are couple of reports and a review article on myositis induced by B19 that supports our finding 12 13 14 . Results of previously reported cases of NOBI had shown B19 genome in serum samples of all eight cases (in three cases resected bowel tissues also) besides anti-B19 antibodies and thrombus in gastric vessels 5 .…”

supporting

confidence: 88%

Real time PCR reconfirmed three novel clinical associations of parvovirus B19: Non-occlusive bowel gangrene, amegakaryocytic thrombocytopenia & myositis

Kishore¹

2015

Indian J Med Res

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supporting

confidence: 88%

Real time PCR reconfirmed three novel clinical associations of parvovirus B19: Non-occlusive bowel gangrene, amegakaryocytic thrombocytopenia & myositis

Kishore¹

2015

Indian J Med Res

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“…Other syndromes for which a causative role for B19V is unclear include generalized edema (963)(964)(965)(966), myositis (967), the onset of diabetes (968) and inflammatory bowel disease (969), uveitis (970), retinal detachment (971), retinal pigment epitheliopathy (972), Rosai-Dorfman histiocytic proliferation (973), laryngitis (974), inner ear disease (975), and testicular tumors (976). B19V DNA persistence in the thyroid after previous infection may account for associations with thyroid cancer (191) and autoimmune thyroiditis (977).…”

Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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“…There are several case reports of parvovirus B19 infection causing myositis in adults, but, in one case series, muscle biopsies in patients with myositis and parvovirus infection did not reveal the presence of B19 DNA, suggesting that parvovirus is not directly responsible for causing the myositis [6, 27]. Nevertheless, there may be an indirect immunologic mechanism involved, as parvovirus infection has been thought to precipitate several autoimmune disorders, most famously rheumatoid arthritis and systemic lupus erythematosis.…”

Section: Discussionmentioning

confidence: 99%

Acquired factor VIII deficiency: two case reports and a review of literature

Bao

2017

Exp Hematol Oncol

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BackgroundAcquired factor VIII (FVIII) deficiency, or acquired hemophilia A (AHA), is a rare autoimmune disorder involving antibody-mediated depletion of coagulation FVIII, leading to severe, life-threatening bleeding. The condition is often associated with other autoimmune disorders, and its treatment involves replacement of FVIII and various modes of immunosuppression. Recently, a few noteworthy therapeutic advances have been made. We present two cases of severe AHA in Chinese women. One of these women developed this disorder in the setting of possible parvovirus B19 infection, which has not yet been reported in association with AHA. Other notable features of her case included paradoxical venous thrombosis and possible association with Sjogren’s syndrome and myositis. The other woman failed to respond to usual first-line therapies despite exhibiting a less severe clinical course, illustrating the varied but potentially stubborn behavior of this disorder.Case 1An 87-year-old woman presented with diffuse ecchymoses, melena, vaginal bleeding. Labs showed hemoglobin (Hgb) nadir of 5.7 mg/dL, elevated partial thromboplastin time (PTT), FVIII level <1%, mixing study consistent with an inhibitor, elevated anti-Sjogren’s-Syndrome-related antigen A antibody, elevated creatinine kinase, and elevated parvovirus IgM and IgG. Imaging of her arm showed diffuse myositis and deep venous thrombosis. After intravenous and oral steroids, her FVIII levels normalized, and her symptoms subsided.Case 2A 59-year-old woman presented with recurrent ecchymoses and hematomas in her extremities. Labs showed Hgb of 11.7 mg/dL, elevated PTT, FVIII level of 3%, and mixing study consistent with an inhibitor. Despite receiving a long course of steroids, several courses of IVIG, and a few courses of Rituximab, her FVIII level remained critically low.ConclusionThe rarity of AHA limits our understanding of this disease and the ability to perform trials to discover optimal therapies. We hope that these case reports and discussion will shed further light on the varied clinical manifestations and natural histories of this disorder to guide better recognition and treatment of AHA.

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A Case Report on Parvovirus B19 Associated Myositis

Cited by 11 publications

References 4 publications

Real time PCR reconfirmed three novel clinical associations of parvovirus B19: Non-occlusive bowel gangrene, amegakaryocytic thrombocytopenia & myositis

Real time PCR reconfirmed three novel clinical associations of parvovirus B19: Non-occlusive bowel gangrene, amegakaryocytic thrombocytopenia & myositis

Human Parvoviruses

Acquired factor VIII deficiency: two case reports and a review of literature

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