A Case Report On Cutaneous Leiomyosarcoma with Review of Literatures

Abstract

Cutaneous leiomyosarcoma represents superficial form of leiomyosarcoma which is a rare mesenchymal tumour originating from smooth muscle cells. Clinically cutaneous leiomyosarcoma can be confused with other cutaneous tumour and needs histopathology and immunohistochemistry to confirm the diagnosis. As it is an uncommon malignant neoplasm we encouraged reporting this case who presented to our hospital as an irregular nodular cutaneous lump of short duration in her right thigh. After local excision histopathological examination of excised specimen established the diagnosis of cutaneous leiomyosarcoma. A brief review of literature is also included here.

Case report of a large lipoma discovered intraoperatively in a chronically irritated implantable cardioverter-defibrillator pocket

“…The occurrence of lipomas on the trunk or extremities is an uncommon event 6–8 , 13 and even rarer in chronically irritated device pockets 12 , 14 , 15 . Previous investigations have shown that lipomatous tumours at 50% represent the most common group of mesenchymal growths with a mostly good prognosis.…”

“…The deeper ones measured over 6 cm and were thus twice the size of the subcutaneous lipomas. In addition, the risk of transformation into a liposacroma or the also mesenchymal, highly malignant cutaneous leiomyosarcoma 13 , 15 increased with tumor size (> 5 cm) and tissue depth. 8 Another smaller study 9 was able to show that 70% of lipomas were caused by sustained tissue stress such as blunt soft tissue injuries with extensive and slowly resorbing haematomas.…”

“…There is also no clear evidence to date on the efficacy of adjuvant chemotherapy or radiotherapy in malignant mesenchymal tumours. 13 Against this background, it seems necessary to identify trigger factors for malignant conversion. Currently, the recommendation remains for the timely surgical removal of suspicious tissue structures with a sufficient safety margin.…”

Invaluable role of histopathology in the diagnosis of cutaneous leiomyosarcoma in insulin injection site reaction

“…11 According to Begum and Hossain, the standard guidelines recommend performing a soft tissue ultrasound scan to confirm the mass and show the plane of the mass. 12 Ultrasonography has been found to be more sensitive compared with palpation for identifying lipohypertrophy (98% and 70%, respectively). 13 In addition, executing an immunohistochemistry (IHC) of a biopsy sample of the mass would reveal prominently actin positive, desmin positive and is CD34 negative.…”