A case report of successful management of clostridium difficile colitis with antegrade Fidaxomicin through a mucous fistula obviating the need for subtotal colectomy

Arnott, Suzanne; Skancke, Matthew; Chen, Sheena W.; Abell, Bruce

doi:10.1016/j.ijscr.2017.11.042

Cited by 2 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additional considerations include addition of vancomycin administered retrograde rectally via enema or antegrade via loop colostomy or mucous fistula. However, these interventions are associated with risk of colonic perforation; therefore, they should be restricted to patients who are unresponsive to standard therapy and the procedure should be performed by personnel with appropriate expertise (1,4,7).…”

Section: Case Reportmentioning

confidence: 99%

Successful management of clostridium difficile colitis with antegrade Vancomycin through a mu-cous fistula eliminating the need for subtotal colectomy

Joseph¹,

Jayasuriya²

2022

Jaffna Med. J.

View full text Add to dashboard Cite

Clostridium difficile (CD) is the most common cause of healthcare-associated infections and can have devastating morbidity and mortality. A 40-year-old diabetic patient who was recently treated for wound sepsis, subsequently developed CD colitis. This patient failed the standard medical therapy for CD colitis, decompensated and required surgical exploration, partial colectomy and mucous fistula creation. Following surgery, her clinical condition improved and her colitis resolved with the antegrade administration of vancomycin through mucous fistula. Traditional treatment algorithms involve oral metronidazole or vancomycin. Our case study report describes the index case of topical vancomycin through a mucous fistula may have reduced the need for total colectomy in the treatment of fulminant CD colitis.

show abstract

Section: Case Reportmentioning

confidence: 99%

Successful management of clostridium difficile colitis with antegrade Vancomycin through a mu-cous fistula eliminating the need for subtotal colectomy

Joseph¹,

Jayasuriya²

2022

Jaffna Med. J.

View full text Add to dashboard Cite

show abstract

Colectomy Averted

Charpentier¹,

Sj²,

Tandon³

2019

Infect Dis Clin Pract

View full text Add to dashboard Cite

Clostridioides difficile infection is considered an urgent public health threat by the Centers for Disease Control and Prevention. Recent practice guidelines recommend either vancomycin or fidaxomicin for an initial episode of C. difficile infection and further recommend a subtotal colectomy in severe cases. There are limited data discussing novel approaches for fidaxomicin administration in severe C. difficile infection to avert colectomy. We describe an off-label route of fidaxomicin administration through a loop ileostomy twice daily with successful outcome.

show abstract

A case report of successful management of clostridium difficile colitis with antegrade Fidaxomicin through a mucous fistula obviating the need for subtotal colectomy

Abstract: HighlightsA novel case report of colon sparing treatment of clostridium difficile colitis.Topical Fidaxomicin may be used to supplement treatment of resistant clostridium difficile colitis.Antegrade administration of Fidaxomicin through a mucous fistula is feasible supplemental therapy.

Cited by 2 publications

References 13 publications

Successful management of clostridium difficile colitis with antegrade Vancomycin through a mu-cous fistula eliminating the need for subtotal colectomy

Successful management of clostridium difficile colitis with antegrade Vancomycin through a mu-cous fistula eliminating the need for subtotal colectomy

Colectomy Averted

Contact Info

Product

Resources

About