A Case Report of Subacute Thyroiditis following mRNA COVID-19 Vaccine

Abstract

Background. Subacute thyroiditis has been reported after administration of influenza vaccine. We describe a case of a patient who developed subacute thyroiditis after administration of. Moderna mRNA COVID-19 vaccine. Case Presentation. A 42-year-old female, with a past medical history of stage IIIB pT3N1aM0 right adenocarcinoma of colon status, after right hemicolectomy on 01/2020, followed by adjuvant chemotherapy, paroxysmal supraventricular tachycardia, iron deficiency anemia, chemotherapy-induced neuropathy, and lumbar radiculopathy, presented to our clinic with anterior neck pain that started 6 days after the second dose of Moderna mRNA COVID-19 vaccine. She was diagnosed with subacute thyroiditis and treated conservatively with pain medications. Conclusion. Subacute thyroiditis could represent one of the side effects of Moderna mRNA COVID-19 vaccine. Further reports are lacking.

Significance of HLA Haplotypes in Two Patients with Subacute Thyroiditis Triggered by mRNA-Based COVID-19 Vaccine

“…In response to the worldwide spread of the COVID-19 pandemic, several vaccine preparations have been developed, including mRNA-based SARS-CoV-2 vaccines (BNT162b2-Pfizer-BioNTech and mRNA-1273-Moderna), an inactivated SARS-CoV-2 vaccine (CoronaVac-Sinovac Life Sciences), and viral vector vaccines (ChAdOx1 nCoV-19-Oxford-AstraZeneca and Ad26.COV2.S-Janssen-Johnson & Johnson). Several cases of SAT triggered by different types of COVID-19 vaccines have already been described [9][10][11][12][13][14][15][16][17][18][19]. However, taking into account the number of 9.79 billion doses of COVID-19 vaccines administered worldwide, SAT appears to be a rare side effect of vaccination.…”

“…Up to January 2022, 9.79 billion doses have been administered globally [8]. Several reports of SAT after various types of COVID-19 vaccines have already been published [9][10][11][12][13][14][15][16][17][18][19]. Rare cases of SAT triggered by other vaccinations have been described before, mainly in regard to influenza or hepatitis B vaccines [20,21].…”

Subacute Thyroiditis After Receiving the mRNA COVID-19 Vaccine (Moderna): The First Case Report and Literature Review in Korea

“…To date, a total of 16 reports with 22 SAT cases after vaccination against COVID-19 have been reported. 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 The clinical features of each patient, including our patient, are summarized in Table 1 . Six types of vaccines have been reported to be associated with SAT: AstraZeneca (6 cases), 2 4 8 9 13 CoronaVac (5 cases), 6 14 15 Pfizer-BioNTech (4 cases), 5 7 11 16 Moderna (3 cases), 2 12 Janssen (1 case), 8 Covaxin (1 case) 17 and cases that did not include the type of vaccine (3 cases).…”

“… 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 The clinical features of each patient, including our patient, are summarized in Table 1 . Six types of vaccines have been reported to be associated with SAT: AstraZeneca (6 cases), 2 4 8 9 13 CoronaVac (5 cases), 6 14 15 Pfizer-BioNTech (4 cases), 5 7 11 16 Moderna (3 cases), 2 12 Janssen (1 case), 8 Covaxin (1 case) 17 and cases that did not include the type of vaccine (3 cases). 3 10 There were more cases of SAT after the first dose (13/23 cases) than after the second dose (10/23 cases).…”

“… 1 As the rate of vaccination against coronavirus disease 2019 (COVID-19) has risen worldwide, reports of COVID-19 vaccine-related SAT are increasing. 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 However, previous reports did not mention the completion of the COVID-19 vaccine when the SAT developed after the first dose of vaccination. Here, we present the first case of severe SAT in Korea in a patient who had received the first dose of mRNA-1273 vaccine (Moderna) and successfully completed his second dose during the treatment.…”