“…5 The patient in this case report lacked some of the typical risk factors reported in the literature, including recent trauma or wounds (30-70% of the time), recent surgery near the affected site (3-4%), diabetes (~45%), consumption of raw or uncooked seafood, or exposure to marine bacteria including Vibrio spp., Aeromonas spp., or Shewanella spp. 5,6 However, the patient did have a history of chronic lymphedema on the ipsilateral side secondary to a history of breast adenocarcinoma treated with radical mastectomy, chemotherapy, and radiation. While the rate of association between chronic lymphedema and necrotizing fasciitis is unknown, Hara et al previously presented a case of a 70-year-old woman with a history of total hysterectomy and pelvic lymphadenopathy for uterine cancer with subsequent chronic lower extremity lymphedema confirmed with lymphoscintigraphy that went on to develop rapidly progressing necrotizing fasciitis of the left thigh and lower leg.…”