A case report of primary fibrosarcoma of the liver

Ito, Yukari; Uesaka, Yoshikazu; Takeshita, Satoshi; Fujino, Hitoshi; Uta, Yoshiki; Yasuda, Hiroshi; Oshima, Masamichi; Kawabe, Takao; Tagawa, Kunio; Unuma, Tadao; Nakahama, Masao; Takanashi, Riichiro

doi:10.1007/bf02779191

Cited by 13 publications

(5 citation statements)

References 15 publications

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“…TAH has been associated with both SFT 5,8-10 and fi brosarcoma of the liver. [12][13][14][15][16] PET scan in the present patient did not demonstrate any areas of hypermetabolism, and thus excessive utilization of glucose by the tumor 20 was not the mechanism of the hypoglycemia. The evidence in our molecular analysis supports the systemic effect of pro-IGF2, produced and secreted by the tumor, as the etiology.…”

Section: Discussionsupporting

confidence: 39%

Malignant transformation of a solitary fibrous tumor of the liver and intractable hypoglycemia

Chan

Horton

Thyssen

et al. 2007

J Hepatobiliary Pancreat Surg

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Sarcomas of the liver are rare. We report a case of intractable hypoglycemia secondary to a solitary fibrous tumor that underwent malignant transformation into a fibrosarcoma. A 70-year-old man presented with a hepatic mass and tumor-associated hypoglycemia which was resistant to medical management. Blood tests were remarkable only for elevated serum insulin-like growth factor (IGF)-2. The hypoglycemia resolved following resection of a solitary fibrous tumor surrounded by a high-grade fibrosarcoma. Real time reverse transcriptase polymerase chain reaction (RT-PCR) measured elevated levels of IGF2 mRNA in both the solitary fibrous tumor and the fibrosarcoma. Immunoblotting demonstrated a series of bands in the size range of pro-IGF2. Unfortunately, disseminated metastases developed 1 year later, concurrent with a recurrence of hypoglycemia, marked again by elevation of serum IGF2. Solitary fibrous tumors of the liver have a real risk of malignant transformation. The severity of the tumor-associated hypoglycemia may parallel the tumor burden and activity. The syndrome is the systemic effect of IGF2 secreted by the tumor. Surgery can treat the hypoglycemia syndrome and the underlying malignancy.

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Section: Discussionsupporting

confidence: 39%

Malignant transformation of a solitary fibrous tumor of the liver and intractable hypoglycemia

Chan

Horton

Thyssen

et al. 2007

J Hepatobiliary Pancreat Surg

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“…In this case the first histological examination showed a large right atrial mass attached to the lateral wall to be a fibroma with thrombus mass, but without signs of malignity. Only the histological and immunohistochemical findings (positive immunostaining with vimentin antibodies) performed after repeat surgery were compatible with a fibrosarcoma [3]. In the literature, the possibility of malign degeneration of a primary benign fibroma into a fibrosarcoma has been described and this is supported by our case and should be described by CMR images [4].…”

Section: Discussionmentioning

confidence: 74%

“…Primary fibrosarcoma of the liver is an extremely rare neoplasm [1][2][3][4][5]. In this case the first histological examination showed a large right atrial mass attached to the lateral wall to be a fibroma with thrombus mass, but without signs of malignity.…”

Section: Discussionmentioning

confidence: 99%

Primary Fibrosarcoma of the Liver Infiltrating the Right Atrium of the Heart

Kelle¹,

Paetsch²,

Neuß³

et al. 2005

Int J Cardiovasc Imaging

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A rare case of a primary fibrosarcoma of the liver infiltrating the right heart is described in a 72-year-old woman. The patient presented with a history of progressive dyspnea and ascites and her general condition was poor. Preoperative cardiac magnetic resonance (CMR) imaging revealed a large mass, which originated from the liver and had infiltrated the right atrium via the inferior vena cava. The patient underwent tumor resection yet died shortly afterwards. Histologically the mass was classified as a fibrosarcoma with positive immunostaining for vimentin. We report the CMR imaging characteristics in this uncommon case. Preoperative CMR proved to be useful for clinical decision making and the planning of surgery.

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“…The purpose of this case report is to share information on a rare tumor of the liver, a primary fibrosarcoma, as up to the late seventies the literature about this entity was restricted to autopsy diagnosis [1]. To our knowledge there are case reports from various parts of the world [2, 3], but there are no series of cases of primary fibrosarcoma of the liver. Etiologically exposure to cadmium has been linked to carcinogenesis of this disease in animal models [4].…”

Section: Discussionmentioning

confidence: 99%

“…Though few reports recommend chemotherapy [9] in liver metastasis of retroperitoneal fibrosarcoma consisting of cyclophosphamide, vincristine, farmorubicin, and dacarbazine, there is no definite role as treatment for primary lesion of liver. Overall the prognosis reported by most of the authors is dismal [1, 2, 3, 10]. …”

Section: Discussionmentioning

confidence: 99%

Primary Fibrosarcoma of the Liver: We Don’t Know Much

Ali

Shah

et al. 2008

Case Rep Gastroenterol

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A 60-year-old lady presented to us with a right upper abdominal mass. With a clinical diagnosis of liver tumor, she was evaluated with abdominal CT, MRI, nuclear scan, tumor markers, USG guided FNAC and other baseline investigations. On evaluation she had a massive right lobe tumor crossing the midline. In view of the ambiguous diagnosis she was subjected to laparotomy where the lesion was judged unresectable and a biopsy was taken. Histopathological examination showed the rare pathology of primary fibrosarcoma of the liver with features of homogeneous, spindle-shaped cells with abundant collagen fibers showing a classic herringbone pattern. Tissue samples were then sent to another referral cancer hospital for immunohistochemistry and immunoreactive vimentin was found in the tumor cells. Electron microscopically, the tumor cells were rich in rough endoplasmic reticulum without a basement membrane, and were surrounded by large amounts of collagen fibers. The fibroblastic character of the tumor cells was suggested by light and electron microscopy.

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A case report of primary fibrosarcoma of the liver

Cited by 13 publications

References 15 publications

Malignant transformation of a solitary fibrous tumor of the liver and intractable hypoglycemia

Malignant transformation of a solitary fibrous tumor of the liver and intractable hypoglycemia

Primary Fibrosarcoma of the Liver Infiltrating the Right Atrium of the Heart

Primary Fibrosarcoma of the Liver: We Don’t Know Much

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