A case report of primary ovarian fibrosarcoma

Grenier, Paige; Agrawal, Anita; Chibbar, Rajni

doi:10.28933/ijcr-2017-11-2001

Cited by 1 publication

(1 citation statement)

References 7 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mitotically Active Cellular Fibromas (MACF), fibromas, or fibro sarcomas are subdivisions from the Fibrous ovarian tumors [8]. Over the past years the definition of the mitotic activity was changed since it was first set in 1981 by Pratt and Scully, where there was no difference in mitotic activity in relation to the nuclear atypia to determine the aggressiveness of the fibromatous neoplasm [7,8].…”

Section: Discussionmentioning

confidence: 99%

Mitotically active cellular fibroma of the ovary diagnosis and treatment

Dawoud¹,

Elmalik²,

Fatima³

et al. 2021

GSC Biol. and Pharm. Sci.

View full text Add to dashboard Cite

Mitotically active cellular fibroma (MACF) of the ovary is a relatively newly recognized histological disease entity which explains its scarce reporting in literature and unknown prognosis [1]. In this tumor type, high mitotic activity is noticed without severe atypia. These tumors are categorized as benign ovarian tumors with late recurrence, if any. However, we herein report an unusual case of an ovarian mitotically active atypical fibrous tumor case which presented as recurrence within six months of being operated thereby raising suspicion of an element of malignancy. On presentation, the patient suffered from abdominal pain and abdomino-pelvic mass. After imaging confirmed an ovarian neoplastic lesion patient underwent bilateral salpingo-oophorectomy and hysterectomy. Histopathology defined the lesion as “ovarian mitotically active atypical fibrous tumor”. Six months later, abdominal pain recurred for which imagining was done and confirmed a newly developed well defined irregular complex solid cystic mass causing intestinal obstruction giving an impression of a malignant neoplasm, probably ovarian carcinoma. However, histopathology for the new lesion remained the same as was for the previous mass, i.e. mitotically active ovarian fibroma, but with lung and mesenteric lymph nodes metastases. Patient couldn’t be operated on due to her co-morbid conditions, and the mass was vascular. She was given supportive care with consideration to start hormonal therapy and during this period died due to sepsis. This case highlights the importance of having a high suspicion of the possibility of malignancy when mitotically active cellular fibroma manifests as a recurrence of mass as this tumor may tend to have an uncertain malignant potential. Thereby, stressing the importance of long term follow up even after the primary tumor is surgically treated without any surgical difficulty or tumor rupture [2]. Such tumors need to be followed and reported more often to help understanding the way they behave and their management.

show abstract

Section: Discussionmentioning

confidence: 99%