A Case Report of Primary Pulmonary Choriocarcinoma in a Man: Successful Combination of Surgery and Chemotherapy

Abstract

Choriocarcinoma is a malignant tumor that typically appears in gonadal organs and primarily occurs in women of reproductive age. Being a primary extragonadal choriocarcinoma, primary pulmonary choriocarcinoma (PPC) is an extremely rare condition. Due to the rarity of PPC, no standardized treatment has been established so far. However, surgery combined with adjuvant chemotherapy appears to be the most optimal treatment. Here, we report a rare case of a man with PPC that was successfully treated with surgery followed by chemotherapy.

Case report: Molecular profiling facilitates the diagnosis of a challenging case of lung cancer with choriocarcinoma features

“…However, they are not always positive in cancers of lung origins. Indeed, both markers were negative in our case, which was consistent with other reported cases ( 15 , 17 – 19 ). Taken together, these highlight the profound challenges in identifying the tumor’s origin of rare histologic subtypes.…”

“…Diagnosis of this rare subtype of lung cancer is challenging, especially in female patients. In addition to particular morphological feature and detection of β-hCG in cancer cells, it is imperative to rule out any prior gynecologic cancers and molar pregnancy in the patient’s medical history ( 15 ). It’s noteworthy that typical immunohistochemical markers found in lung adenocarcinoma, such as TTF-1 and Napsin A, were negative in lung cancer with choriocarcinoma features.…”

Primary Pulmonary Choriocarcinoma Treated With Neoadjuvant Chemotherapy and Lobectomy: A Case Report

“…PPC is a rare form of extragonadal malignant GCT that requires the following diagnostic criteria: (1) exclusion of primary lesions in gonads, (2) normalization of β-HCG levels after treatment, and (3) confirmation by pathology [ 4 ]. To distinguish from giant cell carcinoma, PPC typically stains negative for TTF-1.…”

Utility of beta‐human chorionic gonadotropin in pleural effusions: Report of an autopsy case of a male patient with primary pulmonary choriocarcinoma

“…However, since there are many reports that surgery and postoperative chemotherapy are effective, 5 , 6 , 7 early diagnosis is important.…”

“…3 The prognosis of this tumor is extremely poor despite surgical treatment and chemotherapy. 4 However, since there are many reports that surgery and postoperative chemotherapy are effective, [5][6][7] early diagnosis is important.…”