A case report of newborn infant with severe COVID-19 in Mexico: Detection of SARS-CoV-2 in human breast milk and stool

Hinojosa-Velasco, Alejandro; de, Paloma V. Bobadilla-Montes; García-Sosa, Lidia E.; Mendoza-Durán, J. Gabriel; Pérez-Méndez, María J; Dávila-González, Eduardo; Ramírez-Hernández, Dolores G.; García‐Mena, Jaime; Zárate-Segura, Paola; Reyes-Ruiz, José Manuel; Bastida-González, Fernando

doi:10.1016/j.ijid.2020.08.055

Cited by 46 publications

(51 citation statements)

References 16 publications

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“…Udugama et al suggest that the results may be influenced by viral load, sample technique, or early disease stage. 15 Those raise concerns about the real validity of a negative pharyngeal swab RT-PCR test in infants born to COVID-19 positive mothers. 16 Therefore, negative RT PCR cannot rule out COVID-19 infection.…”

Section: Discussionmentioning

confidence: 99%

“…Although, nasopharyngeal swab specimen for SARS‐CoV‐2 by RT‐PCR is considered one of the best ways to confirm COVID‐19; however, most studies did not reveal the presence of SARS‐CoV‐2 RNA in the specimens like amniotic fluid, cord blood, breast milk, or vaginal secretions. Udugama et al suggest that the results may be influenced by viral load, sample technique, or early disease stage 15 . Those raise concerns about the real validity of a negative pharyngeal swab RT‐PCR test in infants born to COVID‐19 positive mothers 16 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A neonate born to an infected COVID‐19 mother was tested positive just 24 hours after its birth

Huseynova

Mahmoud

Huseynov

et al. 2021

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A neonate born to an infected COVID‐19 mother was tested positive just 24 hours after its birth

Huseynova

Mahmoud

Huseynov

et al. 2021

Clinical Case Reports

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show abstract

“…Breastfeeding was strongly encouraged where both members of the dyad were positive ( 27 , 30 , 31 ), and further investigation was suggested on the role of IgG antibodies ( 27 ) in the possible protective role of breast milk antibodies on the immunity of the infants ( 33 , 35 ). Among the breast milk samples tested for SARS-CoV-2, 27% (3/11) were positive ( 27 , 28 , 30 , 34 , 35 ), but the milk was not considered to be the cause of infection of the infants ( 29 ).…”

Section: Studies Related To Breastfeeding Of Sars-cov-2–infected Mothmentioning

confidence: 99%

Breastfeeding and COVID-19: From Nutrition to Immunity

et al. 2021

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Breastfeeding not only provides the optimum source of nutrients for the neonate and its first strong shield against infection but also lays the foundation for somatic and psychological bonding between the mother and child. During the current COVID-19 pandemic, although the guidelines of the relevant international and national agencies recommend breastfeeding by SARS-CoV-2–infected mothers, considerable insecurity persists in daily clinical practice regarding the safety of the infants and the perceived advantages and disadvantages of discontinuation of breastfeeding. This is a systematic review of the currently available information regarding the transmissibility of SARS-CoV-2 through or while breastfeeding and the protection against infection that breast milk might provide. The accumulated body of knowledge regarding the role of breast milk in the development of the neonatal immune system and protection against infection by other respiratory viruses is discussed, with a focus on the anti-inflammatory role of the antibodies, microbes, and viruses provided to the infant in breast milk and its relevance to the case of SARS-CoV-2.

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“…Some of these mothers were also found to have 229E in respiratory samples. SARS-CoV-2 had not been found among serum, urine, or vaginal samples from pregnant women with genetic amplification from some reports albeit the numbers assessed were small [41,52,90,95,[162][163][164][165][166][167][168][169]. Edlow et al however did not find maternal viremia in a larger infected cohort [73].…”

Section: Foci Of Virus Excretionmentioning

confidence: 99%

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Cimolai

2021

SN Compr. Clin. Med.

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The maternal-fetal/newborn unit is established at risk for COVID-19 infection. This narrative review summarizes the contemporary and cumulative publications which detail maternal infection, antenatal and newborn infections, and maternal/fetal/newborn management and prevention. There is a wide spectrum of maternal disease, but the potential for severe disease albeit in a minority is confirmed. COVID-19 carries risk for preterm delivery. Pregnant females can suffer multisystem disease, and co-morbidities play a significant role in risk. Congenital infection has been supported by several anecdotal reports, but strong confirmatory data are few. No typical congenital dysmorphisms are evident. Nevertheless, placental vascular compromise must be considered a risk for the fetus during advanced maternal infections. Clinical manifestations of newborn infection have been mild to moderate and relatively uncommon. Proven antiviral therapy is of yet lacking. The mode of delivery is a medical decision that must include patient risk assessment and patient directives. Both presymptomatic and asymptomatic mothers and offspring can complicate infection control management with the potential for spread to others in several regards. In the interim, infections of the maternal-fetal-newborn unit must be taken seriously both for the disease so caused and the potential for further dissemination of disease.

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A case report of newborn infant with severe COVID-19 in Mexico: Detection of SARS-CoV-2 in human breast milk and stool

Abstract: Highlights The first published case of newborn infant SARS-CoV-2 infection in Mexico. SARS-CoV-2 RNA is detected in Human Breast Milk and Stool. The intrauterine infection and breastfeeding could be mechanisms for vertical transmission of SARS-CoV-2.

Cited by 46 publications

References 16 publications

A neonate born to an infected COVID‐19 mother was tested positive just 24 hours after its birth

A neonate born to an infected COVID‐19 mother was tested positive just 24 hours after its birth

Breastfeeding and COVID-19: From Nutrition to Immunity

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

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