A Case Report of Male Inflammatory Breast Cancer

Morita, Yoshifumi; Syoji, Tsuyoshi; Goto, Hideki; Nakajima, Tsuyoshi; Hukasawa, Tomoki; Taniwaka, K.

doi:10.3919/jjsa.66.36

Cited by 4 publications

(7 citation statements)

References 11 publications

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“…In our case, a CT scan clearly demonstrated skin thickening and lymphatic edema as well as a small breast mass. The usefulness of contrast-enhanced MRI for making diagnosis of male inflammatory breast cancer was reported in one case [9]. Histological evaluation of the biopsy specimens revealed the infiltrating duct carcinoma in 6 cases and dermal lymphatic emboli in 4.…”

Section: Discussionmentioning

confidence: 99%

“…In pathological aspects, it is diagnosed by the involvement of the dermal lymphatics with infiltrating cancer cells [2]. The majority of breast cancer patients are women; inflammatory breast cancer in men is extremely rare, with only 9 cases having so far been reported [3][4][5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…The patient who received TAM showed a significant improvement in his skin rash [7]. The patient treated with mastectomy followed by PTX with radiotherapy had survived for 15 months after surgery without recurrence [9]. In our patient, we used oral 5-FU drugs as first-line and second-line chemotherapy because of his advanced age.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, he developed pneumonia due to febrile neutropenia after two cycles of TC therapy. As Morita et al [9] reported the efficacy of PTX for male inflammatory breast cancer, taxanes are expected to become an option for the treatment of male inflammatory breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory breast cancer is a rare entity, accounting for only 0.5-2 % of all invasive breast cancer, but it has a dismal outcome [2]. Inflammatory breast cancer in men is extremely rare, with only 9 cases having been reported [3][4][5][6][7][8][9]. This report presents a case of male inflammatory breast cancer along with a review of the literature.…”

Section: Introductionmentioning

confidence: 99%

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A case of male inflammatory breast cancer

et al. 2013

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This report describes the case of an 85-year-old male with inflammatory breast cancer. The patient presented with diffuse erythema and induration over the right anterior chest wall. Ultrasonography and mammography demonstrated an ill-defined small mass, 8 mm in diameter, in the right breast with skin thickening. A core needle biopsy of the breast mass confirmed the presence of invasive ductal carcinoma. A skin biopsy revealed a diffuse tumor cell infiltration with dermal lymphatic emboli. These findings were compatible with the diagnosis of inflammatory breast cancer. The tumor cells were triple negative for estrogen receptor, progesterone receptor, and HER2/neu. His bone scintigraphy showed multiple bone metastases. Systemic chemotherapy using capecitabine was introduced, but it failed to control the disease. TS-1, as second-line systemic chemotherapy, also resulted in treatment failure. Third-line chemotherapy using docetaxel and cyclophosphamide was then administered and was effective. However, he developed pneumonia due to febrile neutropenia after two cycles of treatment and the chemotherapy was discontinued. The patient died of carcinomatous lymphangiosis 2 years and 3 months after the initial onset of the disease. Male inflammatory breast cancer is challenging because of its rarity, biological uncertainness, diagnostic difficulty, and the fact that it is associated with a very poor prognosis. The establishment of a reliable diagnostic and treatment strategy for male inflammatory breast cancer is therefore needed.

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Section: Discussionmentioning

confidence: 99%