A case report of localized gastric amyloidosis

Wu, Dan; Lou, Jianying; Chen, Jian; Lun, Fei; Liu, Guijie; Shi, Xiaoyu; Lin, Han-Ting

doi:10.3748/wjg.v9.i11.2632

Cited by 38 publications

(47 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are currently no specific treatment options for amyloidosis, but there are some drugs to treat the disease, including melphalan, cyclophosphamide, dimethyl sulfoxide, and colchicine, though the effects are not ideal. Surgery and lymph node cleaning may be the best treatment strategy for localized amyloidosis and prevention of complications (4). The latest report showed the lesions of gastric amyloidosis had completely disappeared after autologous stem cell transplantation (9); thus, autologous stem cell transplantation may be a new direction for future treatment.…”

Section: Discussionmentioning

confidence: 99%

A case of endoscopic ultrasound diagnosis of gastric amyloidosis

Ji¹,

Gu²,

Wu³

et al. 2012

Turk J Gastroenterol

View full text Add to dashboard Cite

Amyloidosis is among a group of diseases caused by a variety of amyloid deposition in the interstitial space that causes damage to cells and organ function, affecting the heart, kidneys, gastrointestinal tract, skin, nervous system, and others. The digestive system is one of the most common encroachment sites of amyloidosis, and it was reported that the gastrointestinal tract was affected in approximately 50-70% of cases (1,2). However, amyloidosis that is limited only to the stomach is rare, and might be prone to misdiagnosis because of its various clinical manifestations and non-specific laboratory tests and imaging examinations. We describe a case of gastric amyloidosis diagnosed by endoscopic ultrasonography (EUS). CASE REPORTA 37-year-old female presented to our hospital with the complaint of abdominal distension for one month. In our hospital, she underwent a gastroscopy examination with biopsies, which showed extensive chyme retention and varying erosion and ulceration of the gastric body ( Figure 1). The pathology showed moderate chronic inflammation and erosion of the gastric body mucosa, with accompanying Helicobacter pylori (Hp) infection.

show abstract

Section: Discussionmentioning

confidence: 99%

A case of endoscopic ultrasound diagnosis of gastric amyloidosis

Ji¹,

Gu²,

Wu³

et al. 2012

Turk J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Amyloidosis of the stomach has been described as flat circular lesions with a fine granular appearance [24] , diffuse thickening of the gastric wall with a tendency to bleed [20,25] , irregularly-shaped, soft, mural tumors [21] , and even as a gastric ulcer with heaped up, friable edges, masquerading as malignancy [26] . In addition, loss of rugal folds and antral narrowing have been reported [27,28] .…”

Section: Discussionmentioning

confidence: 99%

Gastric amyloidoma in patient after remission of Non-Hodgkin’s Lymphoma

Koczka

Goodman

2009

WJGO

View full text Add to dashboard Cite

Amyloidosis is commonly systemic, occasionally organlimited, and rarely a solitary localized mass. The latter, commonly referred to as tumoral amyloidosis, is described as occurring in nearly every organ/tissue. Only a few reports of gastric amyloidosis exist today. We describe a 72 year-old black male from Barbados presenting with 3 d of diffuse abdominal pain. His medical history included Non-Hodgkin's Lymphoma diagnosed five years ago, status-post six rounds of cyclophosphamide, adriamycin, vincristine, prednisone chemotherapy, and currently was in remission. On computed tomography scan of the abdomen, thickening and calcification of the gastric wall was noted along with pneumatosis. On esophagogastroduodenoscopy, a large circumferential friable mass was seen from the gastroesophageal junction to the body. A large nonbleeding 3 cm polyp was also seen in post bulbar area of duodenum. Biopsies were stained with Congo red and gave green birefringence under polarized light, consistent with tumoral amyloidosis. Positron emission tomography scan revealed diffuse gastric mucosa uptake compatible with gastric malignancy without metastatic foci. Treatment for gastric amyloidomas has presently been one of observation or, at most, resection of the amyloid mass. It is not known if our patient required the same approach or if this warranted the re-institution of chemotherapy for Non-Hodgkin's Lymphoma. Until more reports of tumoral amyloidosis are made known, treatment as well as prognosis remain uncertain.

show abstract

“…Amyloidal deposit confined to the stomach is extremely rare [4]. protocols and chemotherapeutic drugs including melphalan and colchicine have been widely used, although their effectiveness in ameliorating this disease has remained to be determined [5]. Some reports have documented that surgical resection with lymph node dissection may be a therapeutic strategy to prevent possible complications such as bleeding and obstruction [8].…”

Section: Discussionmentioning

confidence: 99%

“…Systemic amyloidosis is usually with an unfavorable prognosis while the localized types of this disease such as the localized gastric amyloidosis have a relatively better outcome. AL amyloidosis has a poor prognosis with a median survival of one to two years [5]. The prognosis of AA amyloidosis differs according to the underlying disease [11].…”

Section: Discussionmentioning

confidence: 99%

“…The available follow-up data showed an indolent course. He had no evidence of chronic disorders predisposing him to secondary amyloidosis or amyloid deposition, such as rheumatoid arthritis, tuberculosis, cardiac disease, Local deposition of amyloid in the gastrointestinal system without systemic involvement is an uncommon form [5]. The clinical manifestations of gastric amyloidosis are often uncharacteristic and subclinical.…”

Section: Casementioning

confidence: 99%

See 1 more Smart Citation