A case report of Kaposiform haemangioendothelioma; response with propranolol and steroids

Abstract

Background Kaposiform haemangioendothelioma is a rare vascular tumor and may involve skin, deep soft tissue or bone. It is a locally aggressive tumor usually seen in infants. Here we report a case of kaposiform hemagioendothelioma in a child who responded to propranolol and steroids. Case presentation A 3-year-old male child presented with a swelling below his right knee with characteristic violet skin lesion. There was no evidence of Kasabach–Merritt phenomenon. After no improvement with several attempts at debridement and anti-tubercular treatment; a diagnosis of Kaposiform Haemangioendothelioma was reached on the basis of overall clinical picture and histology. The child was treated with propranolol and steroids and had an excellent clinical response and a near complete resolution on imaging at 5 months. Conclusions These cases are often misdiagnosed and despite a delay in diagnosis have good outcomes with appropriate multimodality management. This case highlights the unique and typical characteristics of kaposiform haemangioendothelioma.

Lymphatic Markers in Kaposiform Hemangioendothelioma: Implications for Tumor Invasiveness and β-blockers efficacy

“…Propranolol combined with vincristine and glucocorticoid therapy can achieve better e cacy [23][24][25] . At present, the e cacy of propranolol in the treatment of KHE is still controversial, and the factors affecting its effectiveness are still unclear.…”

Sirolimus combined with glucocorticoids in the treatment of Kasabach-Merritt phenomenon in a neonate: A case report

“…However, long-term use of glucocorticoids is prone to associated side effects such as hypertension, obesity, acne, Cushing syndrome, and opportunistic infections. [ 12 ] In Recent years, glucocorticoid therapy in combination with other drugs has gradually emerged to reduce the dosage of glucocorticoids or shorten the course of treatment in order to reduce complications. We therefore combined glucocorticoids with sirolimus.…”

Management and Outcomes of Advanced Hemangioendothelioma at a Medical Oncology Clinic in an Indian Tertiary Care Center

“…He had locally advanced and infiltrative disease at the lower extremity, which corroborates with findings of previous studies [ 13 ]. A more detailed description of this case and discussion on KHE has already been published from our center [ 24 ].…”