A Case Report of Gastric Carcinosarcoma with Rhabdomyosarcomatous and Neuroendocrinal Differentiation

Gastric carcinosarcoma presenting as a huge epigastric mass

“…Histological identifi cation of the coexistence of carcinomatous and sarcomatous components in the tumor is indispensable for diagnosis. In all reported cases this coexistence has been confi rmed by using conventional hematoxylin and eosin (H&E) staining, with the additional use of immunohistochemical analyses in some cases [10,[12][13][14].…”

Variants of Gastric Carcinoma: Morphologic and Theranostic Importance

“…However, regardless of the proportion of neuroendocrine carcinoma in total volume of gastric carcinoma, its presence has been correlated with a poor prognosis. Approximately 60% of PSCCS cases are associated with conventional gastric adenocarcinoma, and rare cases with sarcomatoid carcinoma, adenosquamous, and squamous carcinoma variants have been reported [82][83][84][85]. Histologically, diagnostic criteria for PSCCS are identical with those for pulmonary neuroendocrine tumors by the WHO/ International association for the Study of Lung Cancer [86].…”

“…The transition between epithelial and sarcomatoid components can be abrupt but two components may intermix with each other. The epithelial component is predominantly composed of adenocarcinoma but rarely adenosquamous and neuroendocrine cell carcinoma can be accompanied [82,83,140]. Some cases represent atrophic gastritis and dysplasia in the background gastric epithelium [142,145].…”

“…In most instances, the pattern typically resembles that seen in high grade spindle sarcomas which lack specific immunohistochemical markers for identifying the line of differentiation [83,84,141,148]. In some cases, the sarcomatous component can be heterologous, with osteosarcomatous, chondrosarcomatous, and rhabdomyosarcomatous or leiomyosarcomatous differentiation [82,139,146,149,150]. There have been three cases reported showing multidirectional differentiation including rhabdomyosarcoma, osteosarcoma, and chondrosarcoma [139,147,148].…”

Spindle Cell Carcinoma of the Larynx with Rhabdomyoblastic Heterologous Element: A Rare Form of Divergent Differentiation

“…osteo-or chondrosarcomatous) [1][2][3]. Although the presence of rhabdomyosarcomatous elements is fairly frequent in carcinosarcomas at other body sites [4][5][6][7][8], it is extremely rare in the larynx [9,10]. We hereby describe the pathologic and immunohistochemical findings of a laryngeal SPC with rhabdomyosarcomatous differentiation.…”