A case report of endocarditis and spondylitis caused by Brucella melitensis biovar 3

Zhang, Huan; Xie, Sheng‐Xue; Wang, Yue-Li; Zhao, Xiaoli; Yi, Jihai; Wang, Zhen; Liu, Qi; Deng, Xiaoyu; Li, Bingjie; Cui, Buyun; Wang, Yuanzhi; Chen, Chuangfu

doi:10.1186/s12879-021-06142-3

Cited by 9 publications

(11 citation statements)

References 26 publications

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“…It is worth noting that a spinal epidural abscess is an infrequent complication that may occur during spondylitis caused by Brucella species [ 7 ]. Spine brucellosis is a relatively rare but potentially debilitating form of the disease [ 8 ]. Epidural abscesses most commonly affect the lumbar vertebrae, while their involvement in the cervical spine is relatively rare.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Complex Landscape of Spine Brucellosis

Abu Nowar,

Al Dalahmeh,

Alrabadi

et al. 2024

Cureus

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Introduction: Brucellosis is an infectious illness contracted by humans through the consumption of unpasteurized milk and dairy items. Brucella organisms are diminutive, gram-negative, non-motile, and non-spore-forming facultative intracellular, aerobic intracellular coccobacilli residing within the reproductive organs of host animals, leading to conditions such as abortions and sterility. Numerous species of Brucella have been identified, with the following four exhibiting varying degrees of pathogenicity in humans: Brucella melitensis (originating from sheep), Brucella suis (associated with pigs), Brucella abortus (linked to cattle), and Brucella canis (found in dogs). B. melitensis and B. suis demonstrate the highest level of pathogenicity, while B. abortus and B. canis exhibit a more moderate degree of pathogenicity. The illness can progress to systemic involvement, with the musculoskeletal system being particularly susceptible to complications. Spinal epidural abscess is an infrequent complication that may occur during spondylitis caused by Brucella species. Epidural abscesses most commonly affect the lumbar vertebrae, while their involvement in the cervical spine is relatively rare. Objective: In this review, we explore spine brucellosis, covering its epidemiology, pathogenesis, clinical manifestations, diagnostics, and evolving treatments. We aim to enhance early detection, timely intervention, and patient outcomes. Patients and methods: This retrospective chart analysis was conducted by revising all medical files for patients in whom spinal brucellosis was diagnosed and managed. Results: This study was conducted at King Hussein Medical Center (KHMC), Jordan, and included a total of 20 patients who were diagnosed with spine brucellosis during the study period. Within the final cohort, 65% of the patients were male (13/20), with an average age at diagnosis of 47.53±14.98 years (ranging from 4 to 61 years). The female group, on the other hand, had an average age at diagnosis of 51.12±15.55 years (ranging from 3 to 58 years). Statistical analysis of the data revealed no significant demographic differences between the two groups. Regarding the co-morbidities, no statistical differences were observed between the two groups. Examining the occupational status of the two groups, no differences were observed. Also, no differences were observed between the two groups regarding the residence place, or the spinal segment involved. Conclusion: Spine brucellosis, although uncommon, poses a complex clinical challenge. Early diagnosis and a multidisciplinary approach are crucial for effective management. Further research is needed to refine diagnostic tools and treatment guidelines for spine brucellosis.

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Section: Introductionmentioning

confidence: 99%

Exploring the Complex Landscape of Spine Brucellosis

Abu Nowar,

Al Dalahmeh,

Alrabadi

et al. 2024

Cureus

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“…Infected aneurysms and aortic ulcers are uncommon, but they can be fatal as well 6 . According to some research, Brucella‐related endocarditis accounts for fewer than 1% of all brucellosis cases 7 . In Brucella endocarditis, the aortic valve is most frequently impacted, whereas the mitral valve is infrequently affected 8 .…”

Section: Introductionmentioning

confidence: 99%

Massive cardiac vegetation and cardiomyopathy in a 23‐year‐old rancher with brucellosis

Mirhosseini,

Bagheri,

Lak

et al. 2023

Clinical Case Reports

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Key clinical massageA 23‐year‐old rancher was admitted with the diagnosis of brucellosis. In evaluations, a massive vegetation in the aortic valve was seen. A combination of antibiotic therapy and cardiac surgery were performed, it seems this approach reduces mortality and complications.AbstractBrucellosis (also known as “undulant fever,” “Mediterranean fever,” or “Malta fever”) is a zoonotic infection transmitted to humans from infected animals (cattle, sheep, goats, camels, pigs, or other animals) by ingestion of food products (such as unpasteurized dairy products) or by contact with tissue or fluids. It is the most frequent zoonosis globally and a major public health issue in many resource‐poor nations. Endocarditis is one of the rarest and most dangerous consequences of brucellosis. Additionally, the combination of endocarditis with cardiomyopathy increases its rarity. This condition is usually treated with a high level of suspicion Serological, clinical, and epidemiological data can all be used to make a diagnosis. The use of echocardiography aids in the early diagnosis. Due to the high risk of recurrence and the extent of tissue destruction brought on by Brucella, the majority of experts advise an early surgical intervention; nevertheless, other writers assert that low‐risk patients also require cautious therapy. In this article, we discuss the situation of a patient who underwent surgery and had Brucella endocarditis and heart failure. In conclusion, a combination of antibiotic therapy and cardiac surgery, reduces mortality and complications associated with Brucella endocarditis and improves patient quality of life.

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“…Recently, several studies have reported that Brucella melitensis (B. melitensis) biovar 3 is the predominant wild strain in Xinjiang. This strain has been isolated from milk, aborted sheep fetuses, human blood, and Asian badgers (5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Using a Relative Quantitative Proteomic Method to Identify Differentially Abundant Proteins in Brucella melitensis Biovar 3 and Brucella melitensis M5-90

Zhang

Wang²,

Wang³

et al. 2022

Front. Immunol.

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Brucellosis, caused by Brucella spp., is one of the most widespread bacterial zoonoses worldwide. Vaccination is still considered the best way to control brucellosis. An investigation into the differential proteome expression patterns of wild and vaccine strains may help researchers and clinicians differentiate between the strains to diagnose and better understand the mechanism(s) underlying differences in virulence. In the present study, a mass spectrometry-based, label-free relative quantitative proteomics approach was used to investigate the proteins expressed by the wild strain, B. melitensis biovar 3 and compare it with those expressed by B. melitensis M5-90. The higher level of virulence for B. melitensis biovar 3 compared to B. melitensis M5-90 was validated in vitro and in vivo. A total of 2133 proteins, encompassing 68% of the theoretical proteome, were identified and quantified by proteomic analysis, resulting in broad coverage of the B. melitensis proteome. A total of 147 proteins were identified as differentially expressed (DE) between these two strains. In addition, 9 proteins and 30 proteins were identified as unique to B. melitensis M5-90 and B. melitensis biovar 3, respectively. Pathway analysis revealed that the majority of the DE proteins were involved in iron uptake, quorum sensing, pyrimidine metabolism, glycine betaine biosynthetic and metabolic processes, thiamine-containing compound metabolism and ABC transporters. The expression of BtpA and VjbR proteins (two well-known virulence factors) in B. melitensis biovar 3 was 8-fold and 2-fold higher than in B. melitensis M5-90. In summary, our results identified many unique proteins that could be selected as candidate markers for differentiating vaccinated animals from animals with wild-type infections. BtpA and VjbR proteins might be responsible for the residual virulence of B. melitensis M5-90, while ABC transporters and thiamine metabolism associated proteins may be newly identified Brucella virulence factors. All of the identified DE proteins provide valuable information for the development of vaccines and the discovery of novel therapeutic targets.

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A case report of endocarditis and spondylitis caused by Brucella melitensis biovar 3

Cited by 9 publications

References 26 publications

Exploring the Complex Landscape of Spine Brucellosis

Exploring the Complex Landscape of Spine Brucellosis

Massive cardiac vegetation and cardiomyopathy in a 23‐year‐old rancher with brucellosis

Using a Relative Quantitative Proteomic Method to Identify Differentially Abundant Proteins in Brucella melitensis Biovar 3 and Brucella melitensis M5-90

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