A case report of diffuse hyperplastic gastropathy with multiple polypoid formations in a patient with pernicious anemia, Helicobacter pylori infection, hypergastrinemia and hypoalbuminaemia: Do not forget of Ménétrier’s disease

Waisberg, Daniel Reis; Mello, Evandro Sobroza de; Tustumi, Francisco; Szor, Daniel José; Charruf, Amir Zeide; Fuhro, Felipe Emanuel; Waisberg, Jaques; Dias, André Roncon

doi:10.1016/j.ijscr.2020.11.055

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…One patient developed deep vein thrombosis and received anticoagulation therapy, which led to gastrointestinal bleeding[ 12 ]. Iron deficiency anemia in patients with Ménétrier’s disease could be a sign of occult bleeding, but iron malabsorption should also be considered[ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal bleeding as an unusual manifestation of localized Ménétrier’s disease with an underlying lipoma: A case report

Kmiecik¹,

Walczak²,

Samborski³

et al. 2023

World J Gastrointest Endosc

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BACKGROUND Ménétrier’s disease is a rare condition characterized by enlarged gastric folds, usually located in the whole body and fundus of the stomach. This report presents an unusual case of localized Ménétrier’s disease elevated by a submucosal lipoma and thus looking like a polypoid mass and causing an episode of upper gastrointestinal bleeding. The mass was successfully removed with endoscopic submucosal dissection. CASE SUMMARY Esophagogastroduodenoscopy was performed on a 76-year-old male patient after an episode of upper gastrointestinal bleeding, manifesting as fatigue and melena. A large polypoid mass (4 cm × 1 cm) with enlarged mucosal folds was found in the body of the stomach, between the lesser curvature and posterior wall. A small ulcer at the distal end of the mass was identified as the source of the bleeding. Biopsy was negative for neoplasia. Computed tomography showed a submucosal lesion beneath the affected mucosa, most likely a lipoma. The mass was removed en bloc with tunneling endoscopic submucosal dissection. Final pathology determined that the mass included Ménétrier’s disease and a submucosal lipoma. The patient was scheduled for follow-up esophagogastroduodenoscopy. CONCLUSION Localized Ménétrier’s disease can coexist with a submucosal lipoma creating a polypoid mass with risk of bleeding.

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Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal bleeding as an unusual manifestation of localized Ménétrier’s disease with an underlying lipoma: A case report

Kmiecik¹,

Walczak²,

Samborski³

et al. 2023

World J Gastrointest Endosc

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“…The signs and symptoms include abdominal pain, nausea or vomiting, anemia, gastrointestinal bleeding, diarrhea, hypochlorhydria, and peripheral edema, with or without evidence of H.P. and hypoalbuminemia 3 . It is easily misdiagnosed as chronic gastritis, gastric cancer or gastric lymphoma, 2,4 so pathological examination is crucial for the final diagnosis.…”

Section: Figurementioning

confidence: 99%

“…and hypoalbuminemia. 3 It is easily misdiagnosed as chronic gastritis, gastric cancer or gastric lymphoma, 2,4 so pathological examination is crucial for the final diagnosis. The pathological features show hyperplastic gastric folds involving mainly the body and fundus with irregular, tortuous, cystically dilated, and elongated foveolar epithelium, and the mucosal surface showed edema, capillary congestion and chronic inflammatory infiltration.…”

mentioning

confidence: 99%

A rare case of Menetrier's disease‐induced gastric outlet obstruction

Chen

Tsai

Liang

et al. 2023

The Kaohsiung J of Med Scie

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“…Giant hypertrophy of the gastric mucosa is a proliferative gastric disease that was first discovered by French pathologist Pierre Ménétrier in an autopsy and reported in 1888, and was named Ménétrier disease (MD). Dr. Ménétrier reported four cases of MD, which were mainly located in the fundus and body of the stomach, two of which were combined with gastric cancer[ 1 - 3 ]. Therefore, he believed that the disease involved the stomach and the fundus of the stomach, and the antrum was preserved.…”

Section: Introductionmentioning

confidence: 99%

Menetrier’s disease and differential diagnosis: A case report

Wang¹,

Zhao²,

Wang³

et al. 2021

WJCC

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BACKGROUND Gastric mucosal hypertrophy, also known as Menetrier's disease (MD), is more common in men over 50 years of age, and the cause is unknown. The symptoms of the disease are atypical, mostly accompanied by hypoproteinemia and edema, and sometimes accompanied by symptoms such as epigastric pain, weight loss, and diarrhea. Most experts believe that the site of the disease is mainly located in the fundus of the stomach and the body of the stomach. We found that the site of the disease in this patient involved the antrum of the stomach. CASE SUMMARY We introduced the case of a 24-year-old woman who had repeated vomiting for 5 d and was admitted to our hospital. After various examinations such as computed tomography and pathology in our hospital, the final diagnosis of the presented case is MD. The salient feature is that the mucosal folds in the fundus and body of the stomach are huge and present in the shape of gyrus. The greater curvature is more prominent, and there are multiple erosions or ulcers on the folds. The patient did not undergo gastric surgery and did not undergo re-examination. She is drinking Chinese medicine for treatment, and her vomiting and abdominal pain symptoms have improved. This disease is relatively rare in clinical practice, and it is easy to be misdiagnosed as gastric cancer, chronic gastritis and gastric lymphoma, etc . CONCLUSION MD can occur in the antrum, it is necessary to raise awareness of the disease and reduce misdiagnosis.

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A case report of diffuse hyperplastic gastropathy with multiple polypoid formations in a patient with pernicious anemia, Helicobacter pylori infection, hypergastrinemia and hypoalbuminaemia: Do not forget of Ménétrier’s disease

Cited by 5 publications

References 15 publications

Upper gastrointestinal bleeding as an unusual manifestation of localized Ménétrier’s disease with an underlying lipoma: A case report

Upper gastrointestinal bleeding as an unusual manifestation of localized Ménétrier’s disease with an underlying lipoma: A case report

A rare case of Menetrier's disease‐induced gastric outlet obstruction

Menetrier’s disease and differential diagnosis: A case report

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