A case report of cimetidine-induce depressive syndrome

doi:10.1176/ajp.137.11.1451

AJP

1980

DOI: 10.1176/ajp.137.11.1451

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A case report of cimetidine-induce depressive syndrome

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Cited by 19 publications

References 10 publications

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Effects of H₂‐receptor antagonists on the central nervous system

Berlin

1989

Drug Development Research

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Histamine functions as a neurotransmitter in the central nervous system (CNS), and H,-receptor activation can modulate the activity of the CNS. H2-receptor antagonists are known to penetrate the blood-brain barrier and to cause neuropsychiatric effects. It appears that interactions with CNS H,-receptors may account for many of these effects, although receptor interactions unique to certain H,-antagonists may also play a role.

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Effects of H₂‐receptor antagonists on the central nervous system

Berlin

1989

Drug Development Research

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Behavioural effects of histamine and its antagonists: a review

1988

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This review focuses on the behavioural effects of histamine and drugs which affect histaminergic function, particularly the H1- and H2-receptors antagonists. Research in this area has assumed considerable importance with increasing interest in the role of brain histamine, the clinical use of both H1 and H2 antagonists and evidence of nonmedical use of H1 antagonists. Results from a number of studies show that H1 and H2 antagonists have clear, but distinct subjective effects and that H1 antagonists have discriminative effects in animals. While H1 antagonists are reinforcers in certain conditions, histamine itself is a punisher. Moderate doses of H1 antagonists affect psychomotor performance in some situations, but the results are variable. The exceptions are terfenadine and astemizole, which do not seem to penetrate the blood-brain barrier readily. In studies of schedule-controlled behaviour, marked changes in response rate have been observed following administration of H1 antagonists, with the magnitude and direction dependent on the dose and the baseline behaviour. Histamine reduces avoidance responding, an effect mediated via H1-receptors. Changes in drinking and aggressive behaviour have also been observed following histamine administration and distinct roles for H1- and H2-receptors have been delineated. Separate H1- and H2-receptor mechanisms have also been suggested to account for changes in activity level. While the H2 antagonists do not always have strong behavioural effects when administered peripherally, there is evidence that cimetidine has a depressant effect on sexual function. These and other findings reveal an important role for histaminergic systems in a wide range of behaviour.

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Safety of acid-suppressing drugs

et al. 1995

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There is an extensive literature on the adverse effects of drugs that inhibit gastric acid secretion. This study presents a critical examination of interactions between antisecretory drugs and other compounds, the frequency of serious adverse effects relating to various body systems, the safety of antisecretory drugs in pregnancy, and longer-term safety data from postmarketing surveillance studies. While interactions with some other drugs, alcohol, and certain carcinogens are of potential concern, in practice clinically significant reactions appear to be rare if they occur at all. A small number of major side-effects have been documented, but they occur rarely, and postmarketing surveillance has not detected other longer-term sequelae. Safety of these drugs in pregnancy is not established, as data are so few. It is concluded that antisecretory agents, by comparison with most other classes of drugs, are remarkably well tolerated.

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A case report of cimetidine-induce depressive syndrome

Cited by 19 publications

References 10 publications

Effects of H₂‐receptor antagonists on the central nervous system

Effects of H₂‐receptor antagonists on the central nervous system

Behavioural effects of histamine and its antagonists: a review

Safety of acid-suppressing drugs

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Product

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About

A case report of cimetidine-induce depressive syndrome

Cited by 19 publications

References 10 publications

Effects of H2‐receptor antagonists on the central nervous system

Effects of H2‐receptor antagonists on the central nervous system

Behavioural effects of histamine and its antagonists: a review

Safety of acid-suppressing drugs

Contact Info

Product

Resources

About

Effects of H₂‐receptor antagonists on the central nervous system

Effects of H₂‐receptor antagonists on the central nervous system