A case report of bilateral cervical chondrocutaneous remnants with review of the literature

Nasser, Haydar A.; Iskandarani, Fadi; Berjaoui, Tarek T.; Fleifel, Siham

doi:10.1016/j.jpedsurg.2011.01.015

Cited by 17 publications

(9 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…; Nasser et al . ). Wattles were alternatively designated as appendices colli, cervical chondrocutaneous remnants or congenital cartilaginous rest of neck (Weissengruber ; Coras et al .…”

mentioning

confidence: 97%

See 1 more Smart Citation

Wattles in goats are associated with theFMN1/GREM1region on chromosome 10

et al. 2015

View full text Add to dashboard Cite

SummaryThe presence of congenital appendages (wattles) on the throat of goats is supposed to be under genetic control with a dominant mode of inheritance. Wattles contain a cartilaginous core covered with normal skin resembling early stages of extremities. To map the dominant caprine wattles (W) locus, we collected samples of 174 goats with wattles and 167 goats without wattles from nine different Swiss goat breeds. The samples were genotyped with the 53k goat SNP chip for a subsequent genome‐wide association study. We obtained a single strong association signal on chromosome 10 in a region containing functional candidate genes for limb development and outgrowth. We sequenced the whole genomes of an informative family trio containing an offspring without wattles and its heterozygous parents with wattles. In the associated goat chromosome 10 region, a total of 1055 SNPs and short indels perfectly co‐segregate with the W allele. None of the variants were perfectly associated with the phenotype after analyzing the genome sequences of eight additional goats. We speculate that the causative mutation is located in one of the numerous gaps in the current version of the goat reference sequence and/or represents a larger structural variant which influences the expression of the FMN1 and/or GREM1 genes. Also, we cannot rule out possible genetic or allelic heterogeneity. Our genetic findings support earlier assumptions that wattles are rudimentary developed extremities.

show abstract

“…; Nasser et al . ). Wattles were alternatively designated as appendices colli, cervical chondrocutaneous remnants or congenital cartilaginous rest of neck (Weissengruber ; Coras et al .…”

mentioning

confidence: 97%

“…; Nasser et al . ). Wattles in domestic goats already fascinated people in the ancient world, and their appearance is supposed to be selectively neutral (Disselhorst ; Fröhner ).…”

mentioning

confidence: 97%

Wattles in goats are associated with theFMN1/GREM1region on chromosome 10

et al. 2015

View full text Add to dashboard Cite

show abstract

“…It may hence be concluded that whereas external lesions are a consistent feature of the Goldenhar syndrome, the opposite is not true (1,3,(7)(8)(9). The cases we are reporting did not have any indication of Goldenhar syndrome.…”

Section: Discussionmentioning

confidence: 62%

“…The anomalous differentiation and consequent heterotopic tissue by inference should originate from immature pluripotent cells. The stimuli for the process remains unknown but it should be mostly a stochastic event given the lack of family history in most of these cases and also the fact that most of them are unilateral (7,8,9). …”

Section: Discussionmentioning

confidence: 99%

Chondrocutaneous branchial remnants or cartilaginous choristoma: terminology, biological behavior and salience of bilateral cervical lesions

Chander¹,

Dogra²,

Raina³

et al. 2013

TJPATH

View full text Add to dashboard Cite

Objective: To present and critically examine the spectrum of chondrocutaneous branchial remnants or accessory pinna, including rare case of bilateral cervical lesions, and to explain the basis of the biological behavior. Material and Method:Five cases of pediatric chondrocutaneous branchial remnants or accessory pinna were included. The ratios of the longest dimensions of the external ear to that of the accessory tragus/chondrocutaneous branchial remnants were calculated. Results:The size and rate of growth of chondrocutaneous branchial remnants or accessory pinna were found to be inversely proportional to the distance between the lesions and the normal pinna. Conclusion:The current literature and norms of terminology dictate that two different terminologies for lesions that are essentially histologically identical should be avoided. Chondrocutaneous branchial remnants, accessory pinna/tragus and chondroid/ cartilaginous choristomas are identical lesions with similar pathogeneses and should be referred to as choristomas.Key Words: Cartilage, Choristoma, Head and neck neoplasms ÖZ Amaç: Bilateral servikal lezyon olarak ender sunulan kondrokutanöz brankial artıklar ya da aksesuar pinna spektrumunu irdelemek ve biyolojik davranışını tartışmak. Gereç ve Yöntem:Beş çocukluk çağı kondrokutanöz brankial artık ya da aksesuar pinna olgusu sunulmaktadır. Dış kulak ile aksesuar tragus/kondromatöz brankial artıkların en uzun boyutlarının oranları hesaplandı. Bulgular: Kondrokutanöz brankial artık ya da aksesuar pinnanın boyutu ve büyüme hızı, lezyonlar ile normal pinna arasındaki mesafe ile ters orantılıydı.Sonuç: Geniş literatür taraması ve terminolojik açıdan bakıldığında, temelde histolojik olarak aynı olan lezyonların farklı terminoloji ile anılmasından kaçınılmalıdır. Kondrokutanöz brankial artıklar, aksesuar pinna/tragus ve kondroid/kartilajinöz koristomlar patogenez açısından benzer lezyonlar olduklarından koristomlar olarak isimlendirilmelidir.

show abstract

“…Cervical chondrocutaneous branchial remnants are rare, benign, congenital choristomas [1][2][3][4][5][6]. These lesions are analogous to preauricular tags, but are located more inferiorly in the anterolateral neck.…”

Section: Discussionmentioning

confidence: 99%

Cervical Chondrocutaneous Branchial Remnants

Ginat

Johnson

Shogan

2017

Head and Neck Pathol

View full text Add to dashboard Cite

Cervical chondrocutaneous branchial remnants are rare congenital choristomas. These lesions contain a cartilage core surrounded by skin with adnexal structures and subcutaneous fat. Correspondingly, on ultrasound there is a tubular hypoechoic core surrounded by hyperechoic, while on CT there is central intermediate attenuation surrounded by fat attenuation tissues. These features are exemplified in this sine qua non radiology-pathology correlation article. Management includes complete surgical resection and evaluating for potential associated anomalies, such as other branchial apparatus anomalies, as well as cardiac anomalies.

show abstract

A case report of bilateral cervical chondrocutaneous remnants with review of the literature

Cited by 17 publications

References 5 publications

Wattles in goats are associated with theFMN1/GREM1region on chromosome 10

Wattles in goats are associated with theFMN1/GREM1region on chromosome 10

Chondrocutaneous branchial remnants or cartilaginous choristoma: terminology, biological behavior and salience of bilateral cervical lesions

Cervical Chondrocutaneous Branchial Remnants

Contact Info

Product

Resources

About