A case report of asystole after a test dose of ceftriaxone in an adult man

Ceftriaxone Induced Cardiopulmonary Arrest: A Fatal Case Report

“…Therefore, in the present case, cardiopulmonary arrest following anaphylaxis to ceftriaxone (Naranjo ADR probability score = 5) [12] was the probable cause of death. Published literature related to ceftriaxoneinduced anaphylaxis [13][14][15][16][17][18][19][20][21][22][23] is shown in Table 1. Moreover, a 10-year review (1998-2008) of reported cases to the Iranian Pharmacovigilance Centre showed that the most frequently reported serious events with ceftriaxone were cardiac arrest and anaphylactic and anaphylactoid reactions [24].…”

A case report of ceftriaxone-induced cardiopulmonary arrest

“…Lin et al reported 17 cases of ceftriaxone-related anaphylaxis [ 7 ]. However, only 4 case reports on ceftriaxone-induced cardiopulmonary arrest have been published worldwide [ [8] , [9] , [10] , [11] ]. In a case by Riezzo et al, ceftriaxone-related cardiopulmonary arrest occurred in the setting of an intradermal skin test with ceftriaxone, after which cardiopulmonary arrest occurred [ 8 ].…”

“…That patient expired despite approximately 20 minutes of cardiopulmonary resuscitation in the ED. Finally, in a case by Aboul-Fotouh et al, grade IV perianesthetic anaphylaxis occurred in a 44-year-old man after a single injected dose of ceftriaxone was introduced for surgical prophylaxis leading to severe bronchospasm, hypotension, bradycardia, cardiac arrest (asystole), and respiratory arrest [ 11 ]. The patient was successfully resuscitated and regained consciousness 2 hours later.…”

Cefotaxime Induced Anaphylaxis Complicated with Massive Pulmonary Edema: An Intraoperative Hurricane

“…As per French society recommendations, skin allergy testing should be carried out after 5-6 weeks of anaphylaxis. 10 As per the "Algorithm for the use of skin tests in the diagnosis of drug hypersensitivities" patient was educated about his hypersensitivity to Cefotaxime and warned to avoid the drug and other cephalosporins as cross reactivity may exists although rare. Also, adequate documentation of drug allergy was done.…”