A case report of anaplastic carcinoma of the pancreas with remarkable intraductal tumor growth into the main pancreatic duct

Okazaki, Mitsuyoshi; Makino, Isamu; Kitagawa, Hirohisa; Nakanuma, Shinichi; Hayashi, Hironori; Nakagawara, Hisatoshi; Miyashita, Tomoharu; Tajima, Hidehiro; Takamura, Hiroyuki; Ohta, Tetsuo

doi:10.3748/wjg.v20.i3.852

Cited by 16 publications

(12 citation statements)

References 20 publications

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“…Initial symptoms include back pain, abdominal distension, and weight loss. In the early stage of tumor development, blood data reflect the invasion of inflammatory cells into the tumor from the early stage, but tumor marker levels are normal or are only mildly increased, and these are not specific [9, 10].…”

Section: Discussionmentioning

confidence: 99%

An Autopsy Case of Anaplastic Pancreatic Ductal Carcinoma (Spindle Cell Type) Multiple Onset in the Pancreas

et al. 2019

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This is a case of a 75-year-old man who was diagnosed with anaplastic pancreatic ductal carcinoma (spindle cell type). His image findings showed pancreatic head cysts and pancreatic head, body, and tail tumors respectively. EUS-FNA was performed to the pancreatic head and pancreatic body tumors, and the same high atypical type cells suspected of cancer were obtained from either specimen, and finally total pancreatectomy was performed. On the specimen, there were 4 lesions in the pancreas; histology showed that the same anaplastic pancreatic ductal carcinoma (spindle cell type) was obtained from the pancreatic head cyst and the pancreatic tumors.

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Section: Discussionmentioning

confidence: 99%

An Autopsy Case of Anaplastic Pancreatic Ductal Carcinoma (Spindle Cell Type) Multiple Onset in the Pancreas

et al. 2019

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“…ACP has a contrast effect on the periphery of the tumor. [10] As it rapidly increases, it appears as a low density tumor at the necrosis of the central part. Because vascularity of ACP is higher than that of a normal pancreatic ductal carcinoma, [11] if it is found at an early stage, like in the present case, the tumor may be hypervascular.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic pancreatic cancer diagnosed with endoscopic ultrasound guided fine needle aspiration showing hypervascular tumor

Fujimoto¹,

Inatomi²,

Mizuno³

et al. 2018

Medicine

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Rationale:Pancreatic ductal carcinoma is a hypovascular tumor, and characteristic findings are observed on imaging modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI), in most cases.Patient concerns:Here we report a case of anaplastic carcinoma of the pancreas (ACP) with characteristics of hypervascular tumor diagnosed by endoscopic ultrasound guided fine needle aspiration (EUS-FNA). A 70-year-old woman was admitted to hospital because of exacerbation of diabetes. Contrast-enhanced CT revealed a hypervascular tumor at the head of the pancreas.Diagnosis:EUS-FNA was performed. Osteoclast-like giant cells and tumor cells with polymorphic nuclei were found on pathological examination and she was diagnosed with ACP.Interventions:Although it was a surgical indication at the time of diagnosis, the tumor rapidly worsened. Oral administration of TS-1 (tegafur/gimeracil/oteracil) was initiated. Chemotherapy was discontinued after the end of 2 courses because the tumor had increased prominently on CT.Outcomes:She died approximately a year since the onset of the illness.Lessons:ACP occasionally exhibits the characteristics of a hypervascular tumor and may require differentiation from other pancreatic tumors, such as neuroendocrine tumor. Therefore, pathological diagnosis by EUS-FNA at an early stage is important to determine treatment strategies.

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“…It was first reported by Sommers and Meissner as pleomorphic carcinoma. Patients usually have huge tumors showing rapid growth when detected and associated with a very poor prognosis [ 6 ]. It is usually seen as a large cystic pancreatic tumor with areas of hemorrhage and necrosis.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Carcinoma of the Pancreas: A Rare Clinical Entity

Oymacı¹,

Yakan²,

Yıldırım³

et al. 2017

Cureus

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Anaplastic carcinoma of the pancreas (ACP) is a very rare histologic subtype of pancreatic cancer and associated with more aggressive and poor prognosis than pancreatic ductal adenocarcinoma. We aimed to review this rare entity and discuss its clinical features, diagnosis and therapy. We presented a case of a 63-year-old male patient that diagnosed as ACP with cyst formation at a tertiary medical center with a detailed review of the current medical literature. We performed pancreaticoduodenectomy operation with lymph node dissection after diagnosis. Any complication after surgery was not observed. Anaplastic pancreas carcinomas are associated with poor survival when compared to invasive ductal adenocarcinomas. Clinical, radiological, laboratory and histological features may be helpful in making differential diagnosis and should be kept in mind in the diagnosis of this rare pancreatic malignancy.

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A case report of anaplastic carcinoma of the pancreas with remarkable intraductal tumor growth into the main pancreatic duct

Cited by 16 publications

References 20 publications

An Autopsy Case of Anaplastic Pancreatic Ductal Carcinoma (Spindle Cell Type) Multiple Onset in the Pancreas

An Autopsy Case of Anaplastic Pancreatic Ductal Carcinoma (Spindle Cell Type) Multiple Onset in the Pancreas

Anaplastic pancreatic cancer diagnosed with endoscopic ultrasound guided fine needle aspiration showing hypervascular tumor

Anaplastic Carcinoma of the Pancreas: A Rare Clinical Entity

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