A case report of adenosquamous carcinoma of the liver with hepatolithiasis.

Horiuchi, Tetsuya; Sakaguchi, Masahiro; Oka, Sumikazu; Yamamoto, Seiki; Kamada, Y.; Tanaka, Shinji; Tabuse, Katsuyoshi

doi:10.5833/jjgs.24.880

Cited by 8 publications

(7 citation statements)

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“…However, the histogenesis of the tumor is still largely unknown.Someinvestigators support the theory that the tumor might develop by transformation of pre-existing adenocarcinoma in the transitional areas between adenocarcinoma and squamous cell carcinoma (5,6). Concerning the pathogenesis, somereports have demonstrated that ASCis associated with hepatolithiasis (7,8) Concerning the biological relationship of G-CSF and tumor growth, it has been reported that G-CSFalso stimulates nonhematopoietic tumor cells. G-CSF-producing tumor cells expressed a G-CSFreceptor which induces tumor cell growth by G-CSFvia the autocrine pathways (1 1).…”

Section: Introductionmentioning

confidence: 98%

Primary Adenosquamous Carcinoma of the Liver Which Produces Granulocyte-Colony-Stimulating Factor and Parathyroid Hormone Related Protein: Association with Leukocytosis and Hypercalcemia.

et al. 2001

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A 55-year-old man was admitted to our hospital with fever and vomiting. Abdominal computed tomography (CT) revealed multiple low density masses in the liver. A diagnosis of primary adenosquamouscarcinoma of the liver was confirmed by histological examination of a necropsy specimen. The present case showed leukocytosis and hypercalcemia with high levels of serum granulocyte-colony-stimulating factor (G-CSF) and parathyroid hormone related

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Section: Introductionmentioning

confidence: 98%

Primary Adenosquamous Carcinoma of the Liver Which Produces Granulocyte-Colony-Stimulating Factor and Parathyroid Hormone Related Protein: Association with Leukocytosis and Hypercalcemia.

et al. 2001

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“…1,2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] The preoperative diagnosis was extremely difficult, with only three patients correctly diagnosed by aspiration cytology.…”

Section: Discussionmentioning

confidence: 99%

Primary adenosquamous carcinoma of the liver: case report

Suzuki

Hirai

Ota

et al. 2002

Journal of Hepato-Biliary-Pancreatic Surgery

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We describe a case of adenosquamous carcinoma of the liver, including treatment for the recurrence. A 67-year-old man with prolonged high fever was diagnosed with a mass lesion in the left lobe of the liver seen by imaging studies. That mass lesion was histologically diagnosed as cholangiocarcinoma by needle biopsy. Left hepatic lobectomy was performed, and a tumor was found that measured 8.0 x 7.0 x 6.0 cm. It was a yellowish white solid mass without macroscopic invasion of the intrahepatic bile duct. Histological examination of the resected specimen revealed both adenocarcinoma and squamous cell carcinoma. The postoperative course was uneventful, but abdominal computed tomography 3 months after operation revealed seven masses in the remnant liver. We diagnosed recurrence of the tumor, and intrahepatic arterial infusion of cisplatin and 5-fluorouracil was begun. A partial remission resulted. Progression-free survival after chemotherapy lasted 2 months. However, the tumor markers and remnant tumor size increased gradually 9 months after the operation, and he died 14 months after surgery. We also review 41 cases of adenosquamous carcinoma of the liver reported in the Japanese and English language literature, including the present case.

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“…A tumor with both adenocarcinoma and squamous cell carcinoma components has previously been referred to as mucoepidermoid carcinoma, 1–6 adenoacanthoma 7 and adenosquamous carcinoma 8–27 . It sometimes develops in the digestive tract, pancreas, gallbladder and thyroid, but rarely in the liver.…”

Section: Discussionmentioning

confidence: 99%

“…A tumor with both adenocarcinoma and squamous cell carcinoma components has previously been referred to as mucoepidermoid carcinoma, 1-6 adenoacanthoma 7 and adenosquamous carcinoma. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] It sometimes develops in the digestive tract, pancreas, gallbladder and thyroid, but rarely in the liver. Adenosquamous carcinoma of the liver is a special type of intrahepatic cholangiocarcinoma that develops from the biliary epithelial lining cells.…”

Section: Discussionmentioning

confidence: 99%

“…Adenosquamous carcinoma is defined as a cancer con‐taining both squamous and glandular elements in the same lesion. Primary adenosquamous carcinoma of the liver is very rare, with approximately 30 cases 1–27 reported since Pianzola and Durt 1 first identified this carcinoma as mucoepidermoid carcinoma of the liver in 1971. In this report, we present an extremely rare case of a double cancer consisting of separate adenosquamous and hepatocellular carcinomas of the liver which, to our knowledge, has not been previously reported.…”

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confidence: 99%

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Double cancer consisting of adenosquamous and hepatocellular carcinomas of the liver

Zhang¹,

Nonaka²,

Nagayama³

et al. 2001

Pathology International

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A very rare case of a double cancer consisting of adenosquamous and hepatocellular carcinomas of the liver in a 65-year-old-man is discussed. The patient was hospitalized with epigastralgia in May 1997. Abdominal computed axial tomography revealed a tumor located in the left lobe of the liver and a left hepatic lobectomy was performed. The tumor recurred several months after surgery and the patient died on 4 June 1999. At autopsy, both a major tumor mass with extensive involvement, located in the surgical margin, and a small mass located in S7 were discovered. Microscopically, the major tumor was diagnosed as adenosquamous carcinoma and the small one in S7 as hepatocellular carcinoma. To our knowledge, this is the first case of a double cancer consisting of adenosquamous and hepatocellular carcinomas of the liver. The pathological findings support the hypothesis that this tumor developed as a squamous transformation of adenocarcinoma.

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A case report of adenosquamous carcinoma of the liver with hepatolithiasis.

Cited by 8 publications

References 0 publications

Primary Adenosquamous Carcinoma of the Liver Which Produces Granulocyte-Colony-Stimulating Factor and Parathyroid Hormone Related Protein: Association with Leukocytosis and Hypercalcemia.

Primary Adenosquamous Carcinoma of the Liver Which Produces Granulocyte-Colony-Stimulating Factor and Parathyroid Hormone Related Protein: Association with Leukocytosis and Hypercalcemia.

Primary adenosquamous carcinoma of the liver: case report

Double cancer consisting of adenosquamous and hepatocellular carcinomas of the liver

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