A Case Report of Adenoid Cystic Carcinoma of Breast– So Close Yet So Far from Triple Negative Breast Cancer

Kumar, Barath Raj; Padmanabhan, Naveen; Bose, Gajasaraj; Paneer, Venkat

doi:10.7860/jcdr/2015/14283.6164

Cited by 5 publications

(7 citation statements)

References 15 publications

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“…From India, a 40-year-old female with final histopathologic diagnosis of ACC underwent adjuvant external beam radiotherapy and was on follow-up without recurrence for more than a year [9]. From Seoul, Korea [10], the report on 6 patients was to the effect that "Although some of our patients developed local recurrence or distant metastases, all patients had favorable clinical course, and to date, none of the patients has died from complications of her disease."…”

Section: Discussionmentioning

confidence: 95%

Epidemiology of Adenoid Cystic Carcinoma of the Breast in a Developing Community

Onuigbo¹

2016

JOJCS

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A well recognized rare breast entity is the adenoid cystic carcinoma [ACC]. Indeed, a few series have long been reported from several parts of the world. Now, according to the Birmingham [UK] group, there is the concept that the histopathology data pool promotes epidemiological analysis. Therefore, the purpose of this paper is to present from a developing community the data collected from such a pool with reference to women of the Ethnic Group called the Ibos or Igbos, who live mainly in the South-eastern region of Nigeria. Of the sixteen collected examples, most were gathered from the Cosmopolitan City of Enugu. Both sides were affected equally. The 31-50 age groups preponderated, while a particular surgeon dominated the operation scenery. Distant practitioners profit by sending biopsies to a centrally located Reference Laboratory.

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Section: Discussionmentioning

confidence: 95%

Epidemiology of Adenoid Cystic Carcinoma of the Breast in a Developing Community

Onuigbo¹

2016

JOJCS

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“…Our clinical review results are reported in (Table 1). Mean LRFS reported by case reports was 24 months (range 20-48) [3,4,8,[10][11][12]. Mean DFS reported by case series and retrospective series was 87.9% (range 69-100%) [2,5,[13][14][15][16].…”

Section: Resultsmentioning

confidence: 99%

“…Mean DFS reported by case series and retrospective series was 87.9% (range 69-100%) [2,5,[13][14][15][16]. Mean OS reported in case reports was 30 months (range 12-84) [3,4,8,[10][11][12]. Mean 5-years OS reported in retrospective series was 89.7% [2,16,17].…”

Section: Resultsmentioning

confidence: 99%

“…ACCB usually affects women, in whom it is more frequent in the sixth decade of life [2]. Histologically presentation shows a double component both luminal epithelial and basal myoepithelial cells, without oestrogen, progesterone and Her-2 receptor expression [3,4]. Despite its belonging to triplenegative class breast tumor, clinical presentation of this disease is usually isolated to breast gland, in 2% of pts patients (pts) there is a nodal involvement and rarely it can metastasize in other parenchyma [1,2,5,6].…”

Section: Aimmentioning

confidence: 99%

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The role of radiotherapy (RT) in the treatment of Adenoid Cystic Carcinoma of the Breast: case report of RT retreatment and literature review

Smaniotto¹,

Terribile²,

Marazzi³

et al. 2019

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This study reviews the recent literature on the role of definitive radiotherapy (RT) in the management of adenoid cystic carcinoma of the breast (ACCB) and presents comprehensive data on clinical outcomes. A case report of radiotherapy retreatment in ACCB is reported for first time in literature. Methods: The authors performed a literature review using PubMed (1981-2019) to identify all studies that match with keywords. Inclusion criteria were articles reporting patients underwent radiotherapy after ACCB diagnosis with follow up reporting. Data analyzed were number of pts, age, study design, multimodality treatment management with radiotherapy schedule, stage of disease, pathological risk factors, local relapse free survival (LFRS), metastases free survival (MFS) and overall survival (OS). Results: Of the 60 identified studies, 15 met the inclusion criteria. All studies had a retrospective design. Overall, 967 patients (median, 64; range, 1-478) were included. A high heterogeneity was found across studies in terms of pathological features available, local approach in multimodality management, adjuvant RT administration, and reported outcomes. Mean LRFS reported by case reports was 24 months (range 20-48). Mean DFS reported by case series and retrospective series was 87.9% (range 69-100%). Mean OS reported in case reports was 30 months (range 12-84). Mean 5-years OS reported in retrospective series was 89.7%. Mean 10-years OS reported in retrospective series was 78.7%. In some retrospective series radiotherapy was found significantly related to local control (p=0.03) and with an absolute survival benefit of 9% at 5 year and of 21% at 10 years (p=0.005). Conclusion and implications for practice: To our knowledge this is the first report on radiotherapy retreatment in ACCB local relapse. This study also reviews the recent literature on the role of adjuvant RT in the management of ACCB and presents comprehensive data on long-term clinical outcome. Some significant results about RT are improvement in local control and survival benefit also since at 10 years in some series. Further studies are needed to confirm these results.

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“…Systemic therapy is indicated for high grade lesion or tumors > 3 cm (13). Hormonal therapy and target therapy is not indicated in these cases due to the triple negative nature of ACC tumors (10).…”

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confidence: 99%

Male Adenoid Cystic Carcinoma of Breast

2017

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Introduction: Adenoid cystic carcinoma (ACC) of the breast is a rare tumor, especially observed in males. Case Presentation: We presented a 42-year-old man, initially diagnosed with small cell carcinoma (SCC) by core needle biopsy. He underwent breast modified radical mastectomy (MRM) and axillary lymph node dissection; his final histopathological diagnosis was ACC. After surgery, although the patient was recommended to have post-operative chemo-radiotherapy, he did not comply. The patient is on follow-up for more than a year with no recurrence until now. Conclusions: ACC of the breast is a rare malignancy with excellent prognosis and favorable tumor biology. It could be mistaken with triple negative breast cancer, ductal carcinoma in situ (DCIC), and small cell carcinoma.

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A Case Report of Adenoid Cystic Carcinoma of Breast– So Close Yet So Far from Triple Negative Breast Cancer

Cited by 5 publications

References 15 publications

Epidemiology of Adenoid Cystic Carcinoma of the Breast in a Developing Community

Epidemiology of Adenoid Cystic Carcinoma of the Breast in a Developing Community

The role of radiotherapy (RT) in the treatment of Adenoid Cystic Carcinoma of the Breast: case report of RT retreatment and literature review

Male Adenoid Cystic Carcinoma of Breast

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