A Case Report of Abnormal Fracture Healing as Detected With High-Resolution Peripheral Quantitative Computed Tomography

Abstract

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Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region: An HR-pQCT exploratory study

“…Thus, we cannot currently state that the calculated stiffness parameters correspond to the actual biomechanical characteristics of the fracture region. Nevertheless, as our earlier studies have also shown, HR-pQCT and μFEA are able to assess both initial fracture features as well as changes during fracture healing with an association with functional outcome [9,12,22].…”

“…The combined score ranges from 0 (no pain/disabilities) to 100 (worst pain/disabilities). PRWE results were clustered in categories according to severity as described elsewhere [16]: none/minimal (0−20), mild (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40), moderate (41-60), severe (61-80) and very severe (81-100).…”

“…1). This group also included a patient who developed complex regional pain syndrome (CRPS) during fracture healing [22].…”

Application of high-resolution peripheral quantitative computed tomography in a clinical setting

“…The effects of both AOMs on bone microarchitecture and strength were not investigated. These effects have been studied using HR-pQCT in postmenopausal women [76][77][78], but they cannot necessarily be extrapolated to GIOP due to differences in the pathophysiology of the bone loss between GIOP and postmenopausal osteoporosis [72]. Correspondingly, the effects of denosumab and risedronate on bone microarchitecture and strength in individuals on GC-treatment remain to be elucidated.…”

“…Additionally, guidelines should be developed for the quality grading of multi-stack scans, the exclusion of multi-stack scans from quantitative analyses based on their quality, and the correction of stack shifts. Besides that, the ability of HR-pQCT to early detect abnormal fracture healing or healing complications should be further explored [78]. Future fracture healing studies may consider using HR-pQCT (or other higher-resolution modalities).…”