A case report: Long-term complete response of metastatic hepatocellular carcinoma obtained after discontinuation of 2-month sorafenib monotherapy

Hirose, Suguru; Ishige, Kazunori; Yamaura, Masamichi; Mizui, Tsuneo; Komatsu, Yasuo; Nagase, Masaomi; Sato, Masashi; Hattori, Junji; Endo, Masato; Hasegawa, Naoyuki; Fukuda, Kuniaki; Hyodo, Ichinosuke

doi:10.1007/s12328-020-01154-z

Cited by 2 publications

(1 citation statement)

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“…AFP is commonly used for PLC diagnosis but is associated with poor sensitivity and specificity. Recent research has shown that the combined assay of AFP with other tumor markers might potentiate the diagnostic efficiency [ 8 ]. TSGF is a polypeptide secreted during the production and proliferation of malignant tumors, and its secretion mechanism is irrelevant to liver injuries caused by benign liver diseases such as liver cysts and cirrhosis [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Multislice Spiral Computed Tomography Combined with Serum AFP, TSGF, and GP73 Assay in the Diagnosis of Primary Liver Cancer

Sun

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the diagnostic value of multislice spiral computed tomography (MSCT) scan combined with serum alpha-fetoprotein (AFP), tumor-specific growth factor (TSGF), and Golgi protein73 (GP73) assays in the diagnosis of primary liver cancer (PLC). Methods. Totally, 60 patients with PLC admitted to The Second Hospital of Dalian Medical University from January 2019 to January 2020 were included in group A, 60 patients with liver cirrhosis were included in group B, and 60 healthy subjects were included in group C. The serum AFP, TSGF, and GP73 levels were determined, and all participants received MSCT scanning. The diagnostic efficacy of MSCT, assays of serum AFP, TSGF, and GP73, and their combined detection was analyzed. Results. Group A had the highest levels of AFP, TSGF, and GP73, followed by group B, and then group C. The sensitivity, specificity, positive predictive value, and negative predictive value of MSCT for PLC were 80.0%,91.7%, 82.8%, and 90.2%, respectively, while those of combined detection of MSCT plus serum AFP, TSGF, and GP73 for PLC were 100.0%, 93.3%, 88.2%, and 100.0%. The combined detection was associated with significantly a higher detection rate of PLC versus stand-alone detection. Conclusion. MSCT plus serum AFP, TSGF, and GP73 has a higher detection rate versus stand-alone detection, which shows great potential in the diagnosis of PLC.

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Section: Introductionmentioning

confidence: 99%