A Case Report: Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm with Aggressive Neuroendocrine Component

Pham, Quang Duy; Mori, Ichiro; Osamura, R. Yoshiyuki

doi:10.1155/2017/9871687

Cited by 11 publications

(29 citation statements)

References 15 publications

(32 reference statements)

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“…Among 69 studies (n = 667) reporting the grade of differentiation of the neuroendocrine component [11][12][13][14][15][16][17][18][19][21][22][23][24][25][26][27][28][29][54][55][56][57][58][59][60][61][62]68,71,[73][74][75]79,80,82,[84][85][86][87]89,[91][92][93]96,97,100,101], a large proportion of MiNENs (92.5%; n = 617) had a grade 3 neuroendocrine component, whereas 4.3% (n = 29) and 3.1% (n = 21) had a grade 1 and a grade 2 neuroendocrine component, respectively. Among MiNENs with a grade 3 neuroendocrine component, the morphological subtype (large cell or small cell) was reported in 25 studies (n = 241) [11,…”

Section: Clinical-pathological Characteristics Treatment Modalitiesmentioning

confidence: 99%

“…Interestingly, in 43 studies (n = 61) where more than one diagnostic sample was available [11,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]30,[32][33][34][36][37][38][39][41][42][43][44][45][46][47]49,50,53,55,[59][60][61][62]64,65,96], the initial diagnosis from the first sample collected (either cytological or histological) was in keeping with MiNEN or suspicion of MiNEN in 36.1% (n = 22) of cases, adenocarcinoma in 36.1% (n = 22), poorly differentiated neuroendocrine carcinoma in 21.3% (n = 13), and well differentiated neuroendocrine tumour in 6.6% (n = 4).…”

Section: Clinical-pathological Characteristics Treatment Modalitiesmentioning

confidence: 99%

“…The histology of synchronous or metachronous distant metastases was reported in 14 studies (N = 51) [11,17,22,31,50,57,58,[62][63][64]85,86,92,96], and was consistent with a single or predominant poorly differentiated neuroendocrine component in 60.8% (n = 31) of cases, with a mixture of a neuroendocrine carcinoma and an adenocarcinoma in 33.3% (n = 17), and a single or predominant adenocarcinoma component in 5.9% (n = 3).…”

Section: Clinical-pathological Characteristics Treatment Modalitiesmentioning

confidence: 99%

See 2 more Smart Citations

Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: A Systematic Review of a Controversial and Underestimated Diagnosis

Frizziero

Chakrabarty

Nagy

et al. 2020

JCM

104

140

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Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) represent a rare diagnosis of the gastro-entero-pancreatic tract. Evidence from the current literature regarding their epidemiology, biology, and management is of variable quality and conflicting. Based on available data, the MiNEN has an aggressive biological behaviour, mostly driven by its (often high-grade) neuroendocrine component, and a dismal prognosis. In most cases, the non-neuroendocrine component is of adenocarcinoma histology. Due to limitations in diagnostic methods and poor awareness within the scientific community, the incidence of MiNENs may be underestimated. In the absence of data from clinical trials, MiNENs are commonly treated according to the standard of care for pure neuroendocrine carcinomas or adenocarcinomas from the same sites of origin, based on the assumption of a biological similarity to their pure counterparts. However, little is known about the molecular aberrations of MiNENs, and their pathogenesis remains controversial; molecular/genetic studies conducted so far point towards a common monoclonal origin of the two components. In addition, mutations in tumour-associated genes, including TP53, BRAF, and KRAS, and microsatellite instability have emerged as potential drivers of MiNENs. This systematic review (91 full manuscripts or abstracts in English language) summarises the current reported literature on clinical, pathological, survival, and molecular/genetic data on MiNENs.

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Section: Clinical-pathological Characteristics Treatment Modalitiesmentioning

confidence: 99%

Section: Clinical-pathological Characteristics Treatment Modalitiesmentioning

confidence: 99%

Section: Clinical-pathological Characteristics Treatment Modalitiesmentioning

confidence: 99%

See 1 more Smart Citation

Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: A Systematic Review of a Controversial and Underestimated Diagnosis

Frizziero

Chakrabarty

Nagy

et al. 2020

JCM

104

140

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“…Mixed adenoneuroendocrine carcinoma (MANEC), has been described by WHO as a rare gastrointestinal neoplasm [1], histologically characterized by the presence of at least 30% each of epithelial and neuroendocrine components [2]. The tumor may appear in various levels of the digestive tract including the esophagus, stomach, colon and appendix [3][4][5][6][7], as well as other sites such as the pancreas [8], and urinary bladder [9][10][11][12]. Presence of MANEC in the gallbladder is exceedingly rare [2,[13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Primary Mixed Adenoneuroendocrine Carcinoma (MANEC) of Gallbladder, Report of Two Cases with Different Histologic and Immunohistochemical Features

Parsa¹,

Orlando²,

Narayanan³

et al. 2018

J Tum Res Rep

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Since implementation of immunohistochemistry, the occurrence of neuroendocrine cells in adenocarcinomas of gastrointestinal tract has been well documented and is not uncommon. The mixture of neuroendocrine carcinoma and adenocarcinoma (MANEC), where each represents at least 30% of the neoplasm, is however very uncommon and occurs mostly in the stomach, appendix, and large intestine. Their occurrence in the gallbladder, as the primary site, is exceptionally rare. We present two elderly patients, one male and one female with clinical manifestations of cholecystitis. The cholecystectomy specimens from these patients revealed MANEC. In one patient, the epithelial component was conspicuously papillary and well-differentiated. In our second case, the epithelial component was variably poorly differentiated carcinoma with mixed neuroendocrine collision features. In this paper we describe the clinicopathologic features of these two cases with emphasis on differences in their gross, histologic, and immunohistochemical findings. These differences may be attributed to the proposed varied pathways for the origin of neuroendocrine cells in the gallbladder.

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“…1 These uncommon tumors represent a special type of cancerous tissue, as it is composed of a mixture of two malignant histologically different tumors. 3 Gastric mixed adenoneuroendocrine carcinomas (MANECs) are especially rare, 2 making the current knowledge base surrounding these tumors limited and reliant on a small series of case reports. 4,5 Consequently, diagnostic and treatment options are a topic of ongoing research.…”

Section: Introductionmentioning

confidence: 99%

Gastric mixed adenoneuroendocrine carcinoma case report

Constante

Tufiño

et al. 2019

SAGE Open Medical Case Reports

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Mixed adenoneuroendocrine carcinomas are rare tumors that contain both an exocrine and an endocrine component. Since the latest classification by the World Health Organization and with the aid of immunostaining, more mixed adenoneuroendocrine carcinomas are now identified and diagnosed. Nonetheless, our knowledge of these tumors is still limited, notably concerning gastric variants, as the cases reported in the literature are very limited. The clinical and surgical treatment, including the chemotherapy schemes, the prognosis, and recurrence still represent challenges for the medical teams. We present the case of a 62-year-old woman. After an upper endoscopy revealed multiple polyps and a low-grade neuroendocrine tumor, a D2 radical gastrectomy was performed. A low output esophageal anastomotic leak was discovered in the postoperative period and successfully managed. Pathology revealed a gastric mixed adenoneuroendocrine carcinoma, the first case of this kind reported in Ecuador. Patient is doing well and under constant surveillance up until her 13th postoperative month.

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A Case Report: Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm with Aggressive Neuroendocrine Component

Cited by 11 publications

References 15 publications

Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: A Systematic Review of a Controversial and Underestimated Diagnosis

Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: A Systematic Review of a Controversial and Underestimated Diagnosis

Primary Mixed Adenoneuroendocrine Carcinoma (MANEC) of Gallbladder, Report of Two Cases with Different Histologic and Immunohistochemical Features

Gastric mixed adenoneuroendocrine carcinoma case report

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