A Case Report: Cutaneous Metastasis of Advanced Rectal Cancer with BRAF Mutation

Zhou, Su; Tang, Wei‐Hua; Wang, Qinghua; Xia, Zhengyuan; Jin, Xianyu; Xu, Xianglai; Fu, Jianfei

doi:10.2147/ott.s287064

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Christensen et al reported that the BRAF V600E mutation is associated with an increased risk of cutaneous metastases [40]. Although a few cases of cutaneous metastasis of BRAF-mutant CRC have been reported in fact, the number is small, and further accumulation of cases is needed to explore the relationship between BRAF mutation and cutaneous metastasis [12,20,41]. Yunoki et al reported the first case of cutaneous metastasis of CRC that was MSI-H and BRAF V600E-mutant [42].…”

Section: Discussionmentioning

confidence: 99%

Axillary cutaneous metastasis of colon cancer with microsatellite instability-high and BRAF V600E mutation treated with curative-intent surgery: a case report

Yamai,

Shimada,

Ozeki

et al. 2023

surg case rep

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Background Colorectal cancer (CRC) metastasizes to various organs, while cutaneous metastases are rare. Although there have been several previous reports of axillary cutaneous metastases with other metastases of CRC, there has never been a report of axillary cutaneous metastasis of CRC that could be treated with curative-intent surgery. Case presentation A 68-year-old female was diagnosed with an axillary cutaneous tumor and ascending colon cancer with invasion to the duodenum. Histopathological and immunohistochemical analysis revealed that the axillary cutaneous tumor showed adenocarcinoma and the same expression pattern for cytokeratin 7, cytokeratin 20, and CDX2 as the ascending colon cancer, and that proved to be KRAS–NRAS wild type, MSI-H, and with a BRAF V600E mutation. The patient underwent a two-stage resection with curative intent after receiving neoadjuvant chemotherapy which consisted of one cycle of modified FOLFOX6 followed by two cycles of FOLFOXIRI. During and after the two operations, the patient received a total of nine cycles of modified FOLFOX6 as adjuvant chemotherapy. Two years after the initial surgery, and 1 year and 8 months after the second surgery, the patient is alive without recurrence. Conclusions To the best of our knowledge, this is the first report of axillary cutaneous metastasis of CRC with microsatellite instability-high and BRAF V600E mutation that could be treated with curative-intent surgery. It is important to recognize the presence of such cases for the accurate diagnosis and treatment of CRC with cutaneous metastasis.

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Section: Discussionmentioning

confidence: 99%

Axillary cutaneous metastasis of colon cancer with microsatellite instability-high and BRAF V600E mutation treated with curative-intent surgery: a case report

Yamai,

Shimada,

Ozeki

et al. 2023

surg case rep

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“…However, certain subsets of metastatic colorectal cancer may also lose expression of CDX2. 34,35 Primary cutaneous mucinous carcinoma also expresses other cytokeratins (AE1/AE3, CAM5.2) as well as epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), estrogen receptor (ER), progesterone receptor (PR), and GCDFP-15. 19,26,36,37 The expression of multiple breast markers (ER, PR, and GCDFP-15) makes PCMC difficult to differentiate from metastatic breast cancer on histopathologic and immunohistochemical grounds alone.…”

Section: Histopathologymentioning

confidence: 99%

Primary Cutaneous Mucinous Carcinoma: A Review of the Literature

Freeman,

Russell,

Council

2023

Dermatol Surg

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BACKGROUND Primary cutaneous mucinous carcinoma (PCMC) is an exceedingly rare, low-grade tumor that histologically resembles mucinous carcinoma from other primary sites, such as the breast, gastrointestinal tract, and lungs. OBJECTIVE The purpose of this article was to review the current literature on PCMC as it relates to epidemiology, clinical presentation, histopathology, immunohistochemistry, treatment, and prognosis. MATERIALS AND METHODS An extensive literature review was conducted using PubMed and Ovid MEDLINE to identify articles related to PCMC. RESULTS Several hundred cases have been reported in the medical literature, and surgical resection, whenever feasible, is the standard of care. CONCLUSION The diagnosis of primary cutaneous mucinous carcinoma is one of exclusion, requiring a metastatic work-up to rule out distant primary. Mohs micrographic surgery is a tissue sparing technique that allows complete margin control of these rare neoplasia.

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“…Different conditions that may appear similar to skin metastases include cysts, lipomas, granulomas, and neurofibromas. So, it is very important to do a biopsy of any suspicious cutaneous lesion [4]. In this case report, we will talk about the clinical presentation and imaging findings of cutaneous metastases during the treatment of advanced rectal cancer.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Cutaneous Metastasis of Unresectable Rectal Adenocarcinoma

Akhtar,

Khan,

Rehman

et al. 2024

Cureus

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Colorectal cancer (CRC) is the third most common malignancy. Common metastatic sites for colorectal carcinoma are the lung and liver while cutaneous metastases are extremely rare. Skin metastasis may be an early manifestation of metastatic disease and represents a poor prognosis. Here we present a case of metachronous skin metastasis during chemoradiation treatment in a patient with locally advanced rectal cancer. A young boy aged 19 years presented to our hospital with radiological TNM staging of T3c N1 M0 with circumferential resection margin (CRM) involved. The treatment plan was defunctioning colostomy with neoadjuvant chemotherapy and radiotherapy with a later plan for surgery. Seven months later, there is a focal skin nodule in the nape of the neck. A core biopsy of this cutaneous nodule was done and proved metastatic. Surgery for the primary tumor and oligometastatic site was planned but due to extensive primary tumor, surgery was terminated and continues with chemotherapy and reassessment.

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A Case Report: Cutaneous Metastasis of Advanced Rectal Cancer with BRAF Mutation

Cited by 4 publications

References 15 publications

Axillary cutaneous metastasis of colon cancer with microsatellite instability-high and BRAF V600E mutation treated with curative-intent surgery: a case report

Axillary cutaneous metastasis of colon cancer with microsatellite instability-high and BRAF V600E mutation treated with curative-intent surgery: a case report

Primary Cutaneous Mucinous Carcinoma: A Review of the Literature

A Rare Case of Cutaneous Metastasis of Unresectable Rectal Adenocarcinoma

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