Background Current approach to detect the presence of gallbladder carcinoma involves a routine histopathological
examination of all gallbladder specimens, regardless of the clinical characteristics of the patient or macroscopic aspect of
the gallbladder. Available pathological reports were interpreted for the following parameters: age, gender, and pathological diagnosis. In
addition, the demographic information and clinicopathologic characteristics of the patients with histopathologic ndings were assessed in detail,
and re-examination of the available specimens was done. Inpatient records of the Methods patients who had been operated for elective and
emergency cholecystectomies in the hospital associated with Khaja Bandanawaz University – Faculty of medical Sciences; from January 2018 to
November 2022, were retrospectively evaluated. Results A total of 661 gallbladder specimens submitted for histopathological examination
during the study period were included in the study. The results of histopathological examination of these gallbladder specimens showed that
chronic cholecystitis was found in 535 (81%), acute cholecystitis in 46 (6.99%), cholesterolosis in 44 (6.5%) patients, Dysplasia was found in 34
(5.14%) patients, and gallbladder carcinoma was detected in 2 (0.30%) patients. Conclusion A strategy of selective approach for
histopathological examination of gallbladder specimens may be safe in areas with very low incidence of gallbladder carcinoma. Such selective
strategy is more cost-effective, reduces the workload of pathologists, and does not appear to compromise patient outcome.