A case-referent study on nasal cancer and exposure to wood dust in the province of Siena, Italy.

Battista, Giuseppe; Cavallucci, F; Comba, Pietro; Quercia, Alessandro Domenico; Vindigni, Carla; Sartorelli, E

doi:10.5271/sjweh.2446

Cited by 31 publications

(17 citation statements)

References 5 publications

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“…The results of this analysis in regard to the relationship between sino-nasal adenocarcinoma and exposure to wood dust corroborate the findings of previous studies both within [Brinton et al, 1984;Comba et al, 1992b;Hayes et al, 1986a;Luce et al, 1992, 19931 andoutside [Acheson et al, 1968;Battista et al, 1983;Cecchi et al, 1980;Loi et al, 1989;Olsen and Asnaes, 19861 of this pooled analysis. An excess risk of adenocarcinoma was observed among men employed in a number of wood-related job categories, including sawmills, furniture and other wood product manufacturing, and carpentry workers.…”

Section: Discussionsupporting

confidence: 81%

“…There also appear to be geographic patterns. Many of the studies with the highest excess risks are European [Acheson et al, 1968;Battista et al, 1983;Comba et al, 1992a;Hayes et al, 1986a;Luce et al, 1992;Magnani et al, 1993;Olsen and Asnaes, 19861 while moderately elevated risks have been consistently observed in North American [Brinton et al, 1984;Elwood, 1981;Vaughan and Davis, 19911 and Asian [Fukuda and Shibata, 1990;Shimizu et al, 1989;Zheng et al, 19921 countries. This may be associated with differences in histology and it has been noted that a high proportion of nasal cancers in Japan are squamous cell [Fukuda et al, 19891. Most case-control studies of sino-nasal cancer have lacked the power to examine the relative risk of adenocarcinoma and squamous cell carcinoma associated with specific jobs or to examine dose-response relationships.…”

Section: Introductionmentioning

confidence: 99%

“…Dose-response relationships have been observed in regard to duration of employment [Acheson et al, 1968;Bolm-Audorf et al, 1990;Luce et al, 1992;Magnani et al, 19931 and surrogate measures of intensity of exposure [Acheson et al, 1968;Hayes et al, 1986a;Luce et al, 19931. Particularly large excesses of sino-nasal adenocarcinoma have been observed [Acheson et al, 1968;Battista et al, 1983;Comba et al, 1992a;Hayes et al, 1986a;Luce et al, 1993;Magnani et al, 1993;Olsen and Asnaes, 19861. Smaller excesses of squamous cell sino-nasal cancer have also been observed [Elwood, 1981;Fukuda and Shibata, 1990;Hernberg et al, 1983;Shimizu et al, 1989;Vaughan and Davis, 1991;Voss et al, 19851, although some studies have not observed an excess risk [Brinton et al, 1984;Hayes et al, 1986a;Magnani et al, 1993;Olsen and Asnaes, 19861.…”

Section: Introductionmentioning

confidence: 99%

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Wood dust and sino‐nasal cancer: Pooled reanalysis of twelve case‐control studies

Demers

Kogevinas

Boffetta

et al. 1995

American J Industrial Med

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125

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In order to examine the relationship between wood dust and sino-nasal cancer, data from 12 case-control studies conducted in seven countries were pooled and reanalyzed. The relative risks associated with wood-related jobs and with exposure to wood dust, measured using a job exposure matrix based on occupation and industry titles, were examined using logistic regression. The combined data set consisted of 680 male cases, 2,349 male controls, 250 female cases, and 787 female controls. A high risk of adenocarcinoma among men was associated with employment in wood-related occupations (odds ratio [OR] = 13.5, 95% confidence interval [CI] = 9.0-20.0) and the risk was greatest among men who had been employed in jobs with the highest wood dust exposure (OR = 45.5, 95% CI = 28.3-72.9) and increased with duration of exposure. The risk of adenocarcinoma also appeared elevated among women employed in wood-related jobs (OR = 2.5, 95% CI = 0.5-12.3), but the small number of exposed cases precluded detailed analysis. Women in wood dust-exposed jobs appeared to have an excess of squamous cell carcinoma (OR = 2.1, 95% CI = 0.8-5.5) which increased with duration of exposure. An increased risk of squamous cell carcinoma in men was seen only among those employed for 30 or more years in jobs with exposure to fresh wood (OR = 2.4, 95% CI = 1.1-5.0). The results of this analysis provide strong support to the association between exposure to wood dust in a variety of occupations and the risk of sino-nasal adenocarcinoma and are consistent with the results of individual participating studies, although the magnitude of the excess risk varied. The evidence in regard to squamous cell carcinomas was ambiguous and there was a great deal of heterogeneity observed in individual study results. This may be due to differences in risk associated with exposure to hardwoods and softwoods or with other, as yet to be identified, aspects of exposure.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Wood dust and sino‐nasal cancer: Pooled reanalysis of twelve case‐control studies

Demers

Kogevinas

Boffetta

et al. 1995

American J Industrial Med

Self Cite

125

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“…The importance of the specific types of wood has been difficult to determine, because workers often use several types of wood over their lifetimes. Exposure to the hard wood dusts (beech and oak), either alone or in combination with soft wood dust, is strongly associated with nasal cancer, especially nasal adenocarcinoma [Acheson et al, 1967;Hadfield and Macbeth, 1971;Acheson, 1976;Andersen et al, 1977;Duclos et al, 1979;Marandas et al, 1981;Battista et al, 1983;Hernberg et al, 1983;Grimm et al, 1984;Wilhelmsson and Drettner, 1984;Ernst and Ambrosch, 1986;Wolf et al, 1988;Bolm-Audorff et al, 19891. An association between exposure to a mixture of hard and soft wood dust and an increased risk of epidennoid and anaplastic carcinoma of the nasal cavity has also been suggested [Hernberg et al, 19831.…”

Section: Risk Factorsmentioning

confidence: 99%

“…A relative risk of 7.5 for squamous cell carcinoma of the maxillary sinus in wood workers doing sanding or lathe work compared to a relative risk of 2.9 for all kinds of wood working has been observed in Japan [Fukuda et al, 1987;Shimizu et al, 19891. The length of employment for workers exposed to wood dust who developed nasal cancer varied from 5 to 55 years [Duclos et al, 1979;Engzell, 1979;Boysen and Solberg, 1982;Battista et al, 1983;Grimm et al, 1984;Klintenberg et al, 1984;Avdeeva and Gurvich, 1985;Gibe1 et al, 1985;Ernst and Ambrosch, 1986;Kauppinen et al, 1986;Coquoz and Lehmann, 1989;Kleinasser and Schroeder, 19891. This observation suggests that great variation in exposure levels and/or individual susceptibility may occur.…”

Section: Risk Of Nasal Cancermentioning

confidence: 99%

Carcinogenic effects of wood dust: Review and discussion

L¹,

Dement

1993

American J Industrial Med

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Occupational exposure to wood dust (alone or chemically treated) is associated with an increased risk of developing adenocarcinoma of the nasal cavity. The specific causative agents, i.e., wood dust alone (natural products), wood dust with additives used in the processing or manufacturing of wood products, and/or physical determinants of wood dust and the associated risk factors, are not known or understood. The strongest association of exposure to wood dust and development of nasal cancer is observed in those occupations where workers are exposed to hard wood dust and chemical additives are not used. The time between first occupational exposure to wood dust and the development of adenocarcinoma of the nasal cavity averages 40 years (range 7-70 years). The epidemiological data available are not sufficient to make a definitive assessment between wood dust exposure and increased risk for cancer other than nasal cancer. The toxicity, mutagenicity, and carcinogenicity of wood dust to laboratory animals or in vitro with animal or microbial cells have not been thoroughly studied. Thus there is no direct experimental evidence on the potential hazards of wood dust. Data are insufficient or lacking on 1) wood dust exposure levels in ambient air and worker's breathing zone, and the deposition in the nasal cavity; 2) hard vs. soft wood dusts; 3) particle size and shape; 4) chemical composition of wood dust and the extent of contamination with chemical additives; and 5) interaction between inhaled wood dust, chronic irritation, and tobacco smoking. These data are required so that one can understand the association between wood dust exposure and nasal cavity tumors, along with demographic differences in cancer rates, and to develop strategies for intervention and reduction of disease causing agents in order to reduce risk to wood industry workers.

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Wood Dust

Nylander‐French

2023

Patty's Toxicology

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Occupational exposure to wood dust is associated with an increased risk of respiratory diseases including acute or chronic impairment of lung function, cancers of the nasal cavity, lung, digestive system, and hematopoietic system, asthma, and allergic and nonallergic dermatitis. Most recent studies on occupational wood dust exposures have been focused on respiratory symptoms, lung function, and sinonasal cancer. The specific causative agents, and so on, wood dust alone (natural products), wood dust with additives used in the processing or manufacturing of wood products, and/or physical and chemical properties of wood dust, associated with adverse effects are still poorly understood. This chapter discusses the peer‐reviewed scientific literature published on occupational exposure to wood dust and the associated risks of developing adverse health effects. In future studies, attention is called for robust exposure assessment that includes control of confounding variables, duration of exposure, and sufficient follow‐up time for onset of effects. This information is needed to understand the causation of health effects caused by wood dust exposure and the demographic differences in disease rates as well as to develop strategies for interventions to reduce risks to wood industry workers.

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A case-referent study on nasal cancer and exposure to wood dust in the province of Siena, Italy.

Cited by 31 publications

References 5 publications

Wood dust and sino‐nasal cancer: Pooled reanalysis of twelve case‐control studies

Wood dust and sino‐nasal cancer: Pooled reanalysis of twelve case‐control studies

Carcinogenic effects of wood dust: Review and discussion

Wood Dust

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