A case of zolpidem dependence with extremely high daily doses

Bajaj, Vikrant; Kalra, Ishat; Bajaj, Arushi; Sharma, Devasheesh; Kumar, Rohit

doi:10.1111/appy.12356

Cited by 15 publications

(18 citation statements)

References 12 publications

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“…14 However, to the best of our knowledge, no study has focused on older adults, especially those with psychiatric disorders. Sleep disturbances are associated with treatment with psychotropic medications, 15 impaired cognitive function, 16 increased risk of psychiatric disorders 17 and cardiovascular and metabolic diseases, 18 poor quality of life (QOL), 19 increased consumption of health care services, and economic burden. 20 Sleep disturbances are also risk factors for deterioration and relapse of psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Sleep Disturbances and Their Association With Quality of Life in Older Psychiatric Patients During the COVID-19 Pandemic

Zou

et al. 2022

J Geriatr Psychiatry Neurol

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Aims The negative effect of the COVID-19 pandemic on sleep quality of clinically stable psychiatric patients is unknown. This study examined the prevalence of sleep disturbances and their association with quality of life (QOL) in clinically stable older psychiatric patients during the COVID-19 pandemic. Methods This multicenter, cross-sectional study involved older patients attending maintenance treatment at outpatient departments of four major psychiatric hospitals in China. Patients’ socio-demographic and clinical characteristics were collected. Sleep disturbances, depressive symptoms, and QOL were assessed with the Insomnia Severity Index, the 9-item Patient Health Questionnaire, and 2 items of the World Health Organization Quality of Life-Brief version, respectively. Binary logistic regression analysis was conducted to examine the independent associations of socio-demographic and clinical variables with sleep disturbances, while the association between sleep disturbances and QOL was explored with analysis of covariance. Results A total of 941 patients were recruited. The prevalence of sleep disturbances was 57.1% (95% CI: 53.9–60.2%). Analysis of covariance revealed that QOL was significantly lower in patients with sleep disturbances compared to those without. Multivariate logistic regression analysis showed that sleep disturbances were positively and independently associated with more severe depressive symptoms (OR = 1.32, 95% CI: 1.26–1.37). Compared to patients with major depressive disorder, those with other psychiatric diagnoses had a significantly higher prevalence of sleep disturbances (OR = 1.44, 95% CI: 1.00–2.08). Conclusion Sleep disturbances were common among clinically stable older psychiatric patients during the COVID-19 pandemic. Considering the negative association with QOL, this subpopulation needs regular assessment and timely treatment to reduce their sleep disturbances and improve their QOL.

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Section: Introductionmentioning

confidence: 99%

Sleep Disturbances and Their Association With Quality of Life in Older Psychiatric Patients During the COVID-19 Pandemic

Zou

et al. 2022

J Geriatr Psychiatry Neurol

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“…As a major health challenge in the general population, the prevalence of insomnia has been rising over time globally (1). Insomnia is characterized by difficulty in initiating or maintaining sleep (2,3).…”

Section: Introductionmentioning

confidence: 99%

Gender Difference in the Prevalence of Insomnia: A Meta-Analysis of Observational Studies

et al. 2020

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Objective: Insomnia is a major health challenge in the general population, but the results of the gender differences in the epidemiology of insomnia have been mixed. This is a meta-analysis to examine the gender difference in the prevalence of insomnia among the general population.Methods:Two reviewers independently searched relevant publications in PubMed, EMBASE, PsycINFO, Web of Science from their inception to 16 April 2019. Studies that reported the gender-based prevalence of insomnia according to the international diagnostic criteria were included for analyses using the random-effects model.Results:Eventually 13 articles were included in the meta-analysis. The pooled prevalence of insomnia in the general population was 22.0% [n = 22,980, 95% confidence interval (CI): 17.0–28.0%], and females had a significantly higher prevalence of insomnia compared with males (OR = 1.58, 95% CI: 1.35, 1.85, Z = 5.63, p < 0.0001). Subgroup analyses showed that greater gender difference was associated with the use of case-control study design and consecutive sampling method. Meta-regression analyses also revealed that higher proportion of females and better study quality were significantly associated with greater gender difference.Conclusions:This meta-analysis found that the prevalence of insomnia in females was significantly higher than males in the included studies. Due to the negative effects of insomnia on health, regular screening, and effective interventions should be implemented in the general population particularly for females.

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“…However, to the best of our knowledge, no study has focused on older adults, especially those with psychiatric disorders. Insomnia symptoms are associated with treatment with psychotropic medications (15), impaired cognitive function (16), increased risk of psychiatric disorders (17) and cardiovascular and metabolic diseases (18), poor quality of life (QOL) (19), increased consumption of health care services and economic burden (20). Insomnia symptoms are also risk factor for deterioration and relapse of psychiatric disorders (17).…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: The Prevalence of Insomnia Symptoms and Its Association With Quality of Life Among Clinically Stable Older Patients With Psychiatric Disorders in China During the COVID-19 Outbreak

Zou

et al. 2020

Preprint

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Aims: The negative impact of the COVID-19 outbreak on sleep quality of clinically stable psychiatric patients is unknown. This study examined the prevalence of insomnia symptoms and its association with quality of life (QOL) in clinically stable older psychiatric patients during the COVID-19 outbreak. Methods: This multicenter, cross-sectional study involved older patients attending maintenance-treatment at the outpatient departments of four major psychiatric hospitals in China. Patients’ basic socio-demographic and clinical characteristics were collected. Insomnia symptoms, depressive symptoms, and QOL were assessed with the Insomnia Severity Index (ISI), Patient Health Questionnaire (PHQ-9), and two items of the World Health Organization Quality of Life-brief version (WHOQOL-BREF), respectively. Binary logistic regression analysis was conducted to examine the independent associations of socio-demographic and clinical variables with insomnia symptoms, while the association between insomnia symptoms and QOL was examined with analysis of covariance.Results: A total of 941 patients were recruited. The prevalence of insomnia symptoms was 57.1% (95% CI: 53.9-60.2%). Analysis of covariance revealed that QOL was significantly lower in patients with insomnia symptoms compared to those without them (P<0.01). Multivariate logistic regression analysis showed that insomnia symptoms were positively and independently associated with more severe depressive symptoms (P<0.01, OR=1.31, 95%CI: 1.26-1.37). Compared to patients with major depressive disorder, those with other psychiatric diagnoses had significantly higher prevalence of insomnia symptoms (P=0.03, OR=1.47, 95%CI: 1.02-2.12).Conclusions: Insomnia symptoms were common among clinically stable older psychiatric patients during the COVID-19 outbreak. Considering their negative impact on QOL, regular assessment and treatment of insomnia symptoms need to be addressed in this population.

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A case of zolpidem dependence with extremely high daily doses

Cited by 15 publications

References 12 publications

Sleep Disturbances and Their Association With Quality of Life in Older Psychiatric Patients During the COVID-19 Pandemic

Sleep Disturbances and Their Association With Quality of Life in Older Psychiatric Patients During the COVID-19 Pandemic

Gender Difference in the Prevalence of Insomnia: A Meta-Analysis of Observational Studies

WITHDRAWN: The Prevalence of Insomnia Symptoms and Its Association With Quality of Life Among Clinically Stable Older Patients With Psychiatric Disorders in China During the COVID-19 Outbreak

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