A Case of X-Linked Moesin-Associated Immune Deficiency in a Pediatric Patient

Zabalo, Celisse; Bindernagel, Constance; Nieves, Daime; Khan, Fatima; Yilmaz, Melis; Potts, David; Ujházi, Boglárka; Csomós, Krisztián; Walter, Jolán E.

doi:10.1016/j.clim.2023.109494

Cited by 2 publications

(1 citation statement)

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“…3,4 As such, specific mutations in this ERM protein have implications in immunodeficiency. 5,6 Studies have demonstrated that Moesin overexpression is associated with various cancer-related processes and can act as a prognostic marker. [7][8][9][10][11] Proteomic and protein co-expression network analysis of Alzheimer's Disease (AD) brain has revealed a module that is enriched in inflammation-related proteins.…”

Section: Introductionmentioning

confidence: 99%

Identification of high-performing antibodies for Moesin for use in Western Blot, immunoprecipitation, and immunofluorescence

Alshafie,

Ayoubi,

Fotouhi

et al. 2023

F1000Res

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Moesin is a cytoskeletal adaptor protein, involved in the modification of the actin cytoskeleton, with relevance to Alzheimer’s Disease. Well characterized anti-Moesin antibodies would benefit the scientific community. In this study, we have characterized ten Moesin commercial antibodies in Western Blot, immunoprecipitation, and immunofluorescence using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. These studies are part of a larger, collaborative initiative seeking to address antibody reproducibility by characterizing commercially available antibodies for human proteins and publishing the results openly as a resource for the scientific community. While use of antibodies and protocols vary between laboratories, we encourage readers to use this report as a guide to select the most appropriate antibodies for their specific needs.

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