A Case of Verrucous Carcinoma (Epithelioma Cuniculatum) of the Heel Mimicking Infected Epidermal Cyst and Gout

Arefi, Mahbod; Philipone, Elizabeth; Caprioli, Russell; Haight, John; Richardson, Hugh; Chen, Sheng

doi:10.1177/1938640008322689

Cited by 8 publications

(6 citation statements)

References 9 publications

(10 reference statements)

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“…In 90% of cases, the tumor is found on the feet, usually in the plantar region, mostly in the ball of the foot. 11,12 Exceptionally, other locations have been described: hands, fingers, buttock, penis, knees, abdominal wall, intertriginous areas and mucous membranes (oral and nasal cavity, larynx, pharynx, esophagus). 2,7 Clinically and histologically, this tumor simulates a variety of benign skin lesions due to its indolent course and the presence of well--differentiated tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma Cuniculatum with Bone Invasion Mimicking a Viral Wart

Guerra

Simões

Vieira³

et al. 2021

SPDV

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Carcinoma cuniculatum is a rare variant of low-grade and well-differentiated squamous cell carcinoma. It is a locally invasive tumor, although it has low metastatic potential. It was originally described in the plantar region but may exceptionally appear in other locations. It predominates in middle-aged men and presents clinically as an exophytic, solitary, painful tumor, with insidious growth. Histologically, this tumor simulates a variety of benign dermatoses and may require several biopsies for the correct diagnosis. It is often misdiagnosed as a viral wart, due to the clinical similarity and the indolent course. The treatment of choice is surgical excision due to the high risk of recurrence and locally aggressive behavior. Amputation can be performed in cases of deep tissue invasion. We present a case of carcinoma cuniculatum in which the late diagnosis favored the invasion of the underlying bone, resulting in amputation of the affected finger.

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Section: Discussionmentioning

confidence: 99%

Carcinoma Cuniculatum with Bone Invasion Mimicking a Viral Wart

Guerra

Simões

Vieira³

et al. 2021

SPDV

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“…The medical literature contains many articles and case reports of carcinoma cuniculatum which on a closer look would be better interpreted as verrucous carcinoma. Only very few case reports can actually be considered carcinoma cuniculatum as originally described by Aird, and ironically, in one of these case reports, the authors refer to a tumor as ‘verrucous carcinoma’ despite the tumor's lack of verrucous features. In all of these case reports, the terms carcinoma cuniculatum and verrucous carcinoma are used interchangeably, showing the ongoing confusion surrounding these two entities.…”

Section: Discussionmentioning

confidence: 99%

“…Recognition of the non‐verrucous nature of carcinoma cuniculatum could have prevented a delay in the diagnosis of our patient. Cases true to Aird's description, such as this one, are exceedingly rare with less than 10 cases in the literature …”

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confidence: 82%

Carcinoma cuniculatum: not a verrucous carcinoma

Kubik

2012

J Cutan Pathol

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“…For patients with EC recurrence, the most common secondary treatment was repeat excision with wider margins (1-2 cm) or amputation (5/11). [49][50][51][52] Few postoperative complications were reported but included pain, infection, and difficulty walking, which were mostly associated with repair modality (eg, split-thickness skin grafts, rotational flaps). 53 Amputation was the second most c o m m o n treatment modality, with a 67% (29/43) incidence of recurrence.…”

Section: Treatment Modalitiesmentioning

confidence: 99%

Epithelioma Cuniculatum (Plantar Verrucous Carcinoma): A Systematic Review of Treatment Options

Daniel¹

2023

Cutis

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CLINICAL REVIEWEpithelioma cuniculatum (EC) is a subtype of verrucous carcinoma (VC) that affects the feet. Treatment involves complete tumor removal by wide local excision (WLE) or Mohs micrographic surgery (MMS). Extensive local destruction may require amputation. We sought to compare reported treatment methods for EC and determine their efficacy by assessing for tumor recurrence and treatment-associated complications. A systematic review of the literature spanning multiple databases was performed. To date, surgical excision is recommended as the standard of care for treatment of EC, with amputation considered in more advanced cases. Mohs micrographic surgery appears to be a promising treatment modality for EC and may have lower recurrence rates than WLE but requires further investigation.Cutis. 2023;111:E19-E24.V errucous carcinoma (VC) is an uncommon type of well-differentiated squamous cell carcinoma (SCC) that most commonly affects men in the fifth to sixth decades of life. 1 The tumor grows slowly over a decade or more and does not frequently metastasize but has a high propensity for recurrence and local invasion. 2 There are 3 main subtypes of VC classified by anatomic site: oral florid papillomatosis (oral cavity), Buschke-Lowenstein tumor (anogenital region), and epithelioma cuniculatum (EC)(feet). 3 Epithelioma cuniculatum, also known as carcinoma cuniculatum or papillomatosis cutis carcinoides, most commonly presents as a solitary, warty or cauliflowerlike, exophytic mass with keratin-filled sinus tracts and malodorous discharge. 4 Diabetic foot ulcers and chronic inflammatory conditions are predisposing risk factors for EC, and it can result in difficulty walking/immobility, pain, and bleeding depending on anatomic involvement. [5][6][7][8][9] The differential diagnosis for VC includes refractory verruca vulgaris, clavus, SCC, keratoacanthoma, deep fungal or mycobacterial infection, eccrine poroma or porocarcinoma, amelanotic melanoma, and sarcoma. [10][11][12][13] The slow-growing nature of VC, sampling error of superficial biopsies, and minimal cytological atypia on histologic examination can contribute to delayed diagnosis and appropriate treatment. 14 Characteristic histologic features include hyperkeratosis, papillomatosis, marked acanthosis, broad blunt-ended rete ridges with a "bulldozing" architecture, and minimal cytologic atypia and mitoses. 5,6

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A Case of Verrucous Carcinoma (Epithelioma Cuniculatum) of the Heel Mimicking Infected Epidermal Cyst and Gout

Cited by 8 publications

References 9 publications

Carcinoma Cuniculatum with Bone Invasion Mimicking a Viral Wart

Carcinoma Cuniculatum with Bone Invasion Mimicking a Viral Wart

Carcinoma cuniculatum: not a verrucous carcinoma

Epithelioma Cuniculatum (Plantar Verrucous Carcinoma): A Systematic Review of Treatment Options

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