A Case of Verruciform Xanthoma  Arising in the Tongue

Hiraishi, Yukihiro; Tojyo, Itaru; Kiga, Norifumi; Tanimoto, Koji; Fujita, Shigeyuki

doi:10.7860/jcdr/2016/22157.8965

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…Microscopically, the presence of verrucous proliferation of squamous epithelium with elongated rete ridges and markedly thickened parakeratin associated with macrophages with foamy cytoplasm due to the presence of lipids (xanthoma cells) are classical morphologic characteristics found in xanthoma ( 9 ), such as observed in present cases reported. The immunohistochemical stains, including positivity for CD68, CD63, or CD163, as used in one of our patients, are not essential for the diagnosis of oral xanthoma but contribute to confirm the macrophage origin of the foamy cells ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

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Oral verruciform xanthomas mimicking potentially malignant disorders

Preto,

Lopes-Santos,

Zanda

et al. 2024

J Clin Exp Dent

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Verruciform xanthoma represents a reactive lesion, common in the skin and somewhat rare in the mouth. Cases description: Two cases of verrucous white plaques, located on the tongue and the floor of mouth of different 30-years-old man and woman and clinically diagnosed as leukoplakia, are described. The histopathological analyses confirmed the diagnosis of oral verruciform xanthomas for both lesions. Practical implications: Despite of uncommon in the oral cavity, the verruciform xanthoma, particularly when affecting regions with a higher risk of developing oral cancer, should be included in differential diagnosis of oral potentially malignant disorders. The histopathological analysis remains as “gold standard technique” for a more accurate diagnosis of oral verruciform xanthoma. Key words: Foam cells, Verruciform xanthoma, Leukoplakia, Tongue.

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Section: Discussionmentioning

confidence: 99%

“…Although there are many cases of oral verruciform xanthoma reported since the 1970s in English literature, this lesion remains little known by health professionals worldwide ( 3 , 4 ).…”

Section: Discussionmentioning

confidence: 99%

Oral verruciform xanthomas mimicking potentially malignant disorders

Preto,

Lopes-Santos,

Zanda

et al. 2024

J Clin Exp Dent

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Oral verruciform xanthoma: Report of 13 new cases and review of the literature

Tamiolakis

Theofilou²,

Tosios³

et al. 2018

Med Oral

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BackgroundOral verruciform xanthoma (OVX) is a rare lesion. The purpose of the present study is to describe the clinical features of 13 OVXs and review all cases reported in the English literature.Material and MethodsThirteen cases of OVX diagnosed during a 47-year period were retrospectively collected. The patients’ gender and age, as well as the main clinical features of the lesions were retrieved from the biopsy request forms. Pubmed®, Scopus® and Google ScholarTM electronic databases were searched with the key word “verruciform xanthoma”. Only cases of histologically confirmed OVX were included in the study.ResultsThe 13 OVXs represented approximately 0.04% of 35,617 biopsies accessioned during the study period. They affected 13 patients, 8 males and 5 females with a mean age of 48.8±14 years. They mainly appeared as asymptomatic granular nodules or plaques, with elastic or normal consistency and white color, in the gingiva or hard palate. Literature review yielded 416 cases of OVX. With the addition of cases of the present study, 429 cases of OVX have been presented in the English literature. OVX has a slight male predominance with a male to female ratio of 1.4:1 and the majority of patients are in the 5th to 7th decade of life. Clinically, OVX mainly presents as an asymptomatic, single, papillary or granular plaque or nodule, with elastic or soft consistency and white, red or pink color. It measures approximately 1cm and is most commonly located on the gingiva, tongue, hard palate or buccal mucosa. The treatment of choice is surgical excision with little rates of recurrence.ConclusionsVerruciform xanthoma is a rare lesion most often encountered on the ginigival mucosa. As its clinical presentation is not pathognomonic, it should be included in the differential diagnosis of verrucous or papillary lesions. Key words:Oral verruciform xanthoma, oral tumors.

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A Case of Verruciform Xanthoma Arising in the Tongue

Cited by 2 publications

References 12 publications

Oral verruciform xanthomas mimicking potentially malignant disorders

Oral verruciform xanthomas mimicking potentially malignant disorders

Oral verruciform xanthoma: Report of 13 new cases and review of the literature

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