A case of true gastric carcinosarcoma treated using laparoscopy-assisted distal gastrectomy

Yuasa, Yasuhiro; Okitsu, Hiroshi; Furukawa, Takako; Kihara, Ayumi; Yamashita, Michiko; Okitsu, Natsu

doi:10.3919/jjsa.73.1110

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…Table 2 shows the clinicopathologic characteristics of early carcinosarcoma of the stomach. 21,23,24 Notably, lymph node metastasis was observed in two of four cases, which indicates the aggressiveness of this type of tumor. Therefore, chemotherapy and radiation therapy as well as surgery may play important roles in its treatment.…”

Section: Discussionmentioning

confidence: 81%

Carcinosarcoma of Stomach Confined to the Mucosa

et al. 2017

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Carcinosarcoma is a malignant tumor composed of both epithelial and mesenchymal malignant tumor components. A 78-year-old man was transferred to our hospital because of hematemesis and tarry stool. An emergency gastrointestinal endoscopic examination revealed active bleeding from an ulcerative lesion on the posterior wall of the gastric body; endoscopic hemostasis was successfully performed. A gastrointestinal endoscopy performed two months later showed a polypoid lesion at the same place where the ulcer had been. The biopsy specimen was histologically diagnosed as well to moderately differentiated tubular adenocarcinoma. The patient underwent a laparoscopic distal gastrectomy with D2 lymph node dissection under a diagnosis of gastric adenocarcinoma. A 28 × 15 mm polypoid tumor was resected from the gastric body, and was found on microscopic examination to consist of both carcinoma and sarcoma components, showing atypical spindle cells, which were positive for α-smooth muscular actin, calponin, and h-caldesmon, but negative for CD34, CD117 (c-kit), desmin, and dog 1. These findings led to a diagnosis of gastric carcinosarcoma. The tumor was confined to the mucous membrane. Lymph node metastasis was found in one node and contained only the carcinoma component. The postoperative course was uneventful. The patient lived without recurrence for 2 years. Carcinosarcoma of the stomach is a rare tumor with high malignant potential and poor prognosis. Careful follow up is required for early detection of any recurrence.

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Section: Discussionmentioning

confidence: 81%

Carcinosarcoma of Stomach Confined to the Mucosa

et al. 2017

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A case of gastric carcinosarcoma with distant metastasis for which chemotherapy with S-1 plus cisplatin was transiently effective

et al. 2014

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An Uncommon Presentation of Carcinosarcoma of the Stomach and a Minimally Invasive Approach for Treatment

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Klymenko

et al. 2022

Case Reports in Gastrointestinal Medicine

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Carcinosarcoma is a rare malignant neoplasm that is composed of both epithelial and mesenchymal tumor components. Gastric carcinosarcoma is even more rare and is often diagnosed at a late stage. In this report, we investigate a case of early gastric carcinosarcoma with regional lymph node metastasis in a 78-year-old woman. The patient underwent partial gastrectomy, lymphadenectomy, and splenectomy. The tumor was confined to the gastric submucosa, and a biopsy specimen led to a histological diagnosis of carcinosarcoma with adenocarcinoma, squamous-cell carcinoma, and undifferentiated pleomorphic sarcoma components. Metastasis was present in one lymph node and displayed osteosarcomatous differentiation. Vigilant monitoring for recurrence and metastatic disease will be required for this patient.

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A case of true gastric carcinosarcoma treated using laparoscopy-assisted distal gastrectomy

Cited by 5 publications

References 6 publications

Carcinosarcoma of Stomach Confined to the Mucosa

Carcinosarcoma of Stomach Confined to the Mucosa

A case of gastric carcinosarcoma with distant metastasis for which chemotherapy with S-1 plus cisplatin was transiently effective

An Uncommon Presentation of Carcinosarcoma of the Stomach and a Minimally Invasive Approach for Treatment

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