A Case of Trichloroethylene Intoxication with Neuropsychiatric Symptoms

Kim, Ja Hyun; Ryu, Seong Jin; Kim, Byoung Gwon; Jhun, Hyung Joon; Park, Jong-Tae; Kim, Hae Joon

doi:10.35371/kjoem.2008.20.1.54

Cited by 4 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The other causes of occupational CNS disorders were organotin ( 26 , 27 ), acetonitrile ( 19 ), and carbon monoxide ( 28 ). In addition, several chronic toxic encephalopathy cases ( 7 , 19 , 24 , 25 , 29 - 31 ) due to mixed solvents had been reported ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Occupational Neurological Disorders in Korea

Kim

Kang

2010

J Korean Med Sci

View full text Add to dashboard Cite

The purpose of this article was to provide a literature review of occupational neurological disorders and related research in Korea, focusing on chemical hazards. We reviewed occupational neurological disorders investigated by the Occupational Safety and Health Research Institute of Korean Occupational Safety and Health Agency between 1992 and 2009, categorizing them as neurological disorders of the central nervous system (CNS), of the peripheral nervous system (PNS) or as neurodegenerative disorders. We also examined peer-reviewed journal articles related to neurotoxicology, published from 1984 to 2009. Outbreaks of occupational neurological disorder of the CNS due to inorganic mercury and carbon disulfide poisoning had helped prompt the development of the occupational safety and health system of Korea. Other major neurological disorders of the CNS included methyl bromide intoxication and chronic toxic encephalopathy. Most of the PNS disorders were n-hexane-induced peripheral neuritis, reported from the electronics industry. Reports of manganese-induced Parkinsonism resulted in the introduction of neuroimaging techniques to occupational medicine. Since the late 1990s, the direction of research has been moving toward degenerative disorder and early effect of neurotoxicity. To understand the early effects of neurotoxic chemicals in the preclinical stage, more follow-up studies of a longer duration are necessary.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Chronic toxic encephalopathy caused by mixed solvent was reported in 10 cases ( 7 , 19 , 24 , 25 , 29 - 31 ), including 3 female and 7 male workers ( Table 4 ). All patients had been exposed to mixed solvents.…”

Section: Resultsmentioning

confidence: 99%

Occupational Neurological Disorders in Korea

Kim

Kang

2010

J Korean Med Sci

View full text Add to dashboard Cite

show abstract

“…Most studies focused on lead and mercury entailed monitoring biological factors in the workplace and the physical health of workers. A few studies evaluated the mental effects of solvents ( 31 - 35 ) and heavy metals (manganese) ( 36 , 37 ) using self-rating scales and neurobehavioral tests.…”

Section: Methodsmentioning

confidence: 99%

Occupational Psychiatric Disorders in Korea

Choi

Kang

2010

J Korean Med Sci

View full text Add to dashboard Cite

We searched databases and used various online resources to identify and systematically review all articles on occupational psychiatric disorders among Korean workers published in English and Korean before 2009. Three kinds of occupational psychiatric disorders were studied: disorders related to job stress and mental illness, psychiatric symptoms emerging in victims of industrial injuries, and occupational psychiatric disorders compensated by Industrial Accident Compensation Insurance (IACI). Korea does not maintain official statistical records for occupational psychiatric disorders, but several studies have estimated the number of occupational psychiatric disorders using the Korea Workers' Compensation and Welfare Service (COMWEL, formerly KLWC) database. The major compensated occupational psychiatric disorders in Korea were "personality and behavioral disorders due to brain disease, damage, and dysfunction", "other mental disorders due to brain damage and dysfunction and to physical diseases", "reactions to severe stress and adjustment disorders", and "depressive episodes". The most common work-related psychiatric disorders, excluding accidents, were "neurotic, stress-related, and somatoform disorders" followed by "mood disorders".

show abstract

Role of Trichloroethylene in Parkinson’s Disease

Goldman

Cash

2014

Trichloroethylene: Toxicity and Health Risks

View full text Add to dashboard Cite

Parkinson's disease (PD) is the second most common neurodegenerative disorder, primarily affecting older adults. Given the projected growth and aging trend of the population, the prevalence of PD is expected to double by the year 2040, highlighting the imperative need for a better understanding of the disease. It is generally accepted that the development of idiopathic PD is multifactorial, involving both genetic and environmental factors; however, relatively little is known about specifi c exposures. An association between TCE exposure and increased PD risk has been suggested by several case reports/clusters, and recently, the fi rst epidemiologic study found a signifi cant six-fold increased risk of PD associated with occupational TCE exposure. Data from animal studies also support a plausible mechanistic pathway, with rodent models demonstrating TCE-induced neurotoxic effects similar to those occurring in PD. Given that TCE is ubiquitous, even a modest increased risk could have enormous population-level neurological health implications.

show abstract

A Case of Trichloroethylene Intoxication with Neuropsychiatric Symptoms

Cited by 4 publications

References 0 publications

Occupational Neurological Disorders in Korea

Occupational Neurological Disorders in Korea

Occupational Psychiatric Disorders in Korea

Role of Trichloroethylene in Parkinson’s Disease

Contact Info

Product

Resources

About