A Case of Traumatic Unilateral Internuclear Ophthalmoplegia: Clinical Significance of Susceptibility-Weighted Imaging

Lee, Shin Heon; Nam, Taek-Kyun; Park, Yong Sook; Kwon, Jeong-Taik

doi:10.13004/kjnt.2016.12.2.140

Cited by 5 publications

(4 citation statements)

References 17 publications

(21 reference statements)

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“…However, these studies did not reconstruct the neural pathway passing through the MLF region. Although many previous studies suggested that the exact location of MLF in the MRI and aspect of injury of MLF in the patients with MS [3,8,32,33], however, that it is difficult to identify injury of MLF with only MRI in patients with stroke or traumatic brain injury [34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional Identification of the Medial Longitudinal Fasciculus in the Human Brain: A Diffusion Tensor Imaging Study

Yeo

Jang

Kwon

et al. 2020

JCM

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Background: The medial longitudinal fasciculus (MLF) interacts with eye movement control circuits involved in the adjustment of horizontal, vertical, and torsional eye movements. In this study, we attempted to identify and investigate the anatomical characteristics of the MLF in human brain, using probabilistic diffusion tensor imaging (DTI) tractography. Methods: We recruited 31 normal healthy adults and used a 1.5-T scanner for DTI. To reconstruct MLFs, a seed region of interest (ROI) was placed on the interstitial nucleus of Cajal at the midbrain level. A target ROI was located on the MLF of the medulla in the reticular formation of the medulla. Mean values of fractional anisotropy, mean diffusivity, and tract volumes of MLFs were measured. Results: The component of the MLF originated from the midbrain MLF, descended through the posterior side of the medial lemniscus (ML) and terminated on the MLF of medulla on the posterior side of the ML in the medulla midline. DTI parameters of right and left MLFs were not significantly different. Conclusion: The tract of the MLF in healthy brain was identified by probabilistic DTI tractography. We believe this study will provide basic data and aid future comparative research on lesion or age-induced MLF changes.

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Section: Discussionmentioning

confidence: 99%

Three-Dimensional Identification of the Medial Longitudinal Fasciculus in the Human Brain: A Diffusion Tensor Imaging Study

Yeo

Jang

Kwon

et al. 2020

JCM

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“…Oxyhemoglobin is diamagnetic as it contains Fe 2+ , whereas deoxyhemoglobin has four unpaired electrons and is therefore paramagnetic. Deoxyhemoglobin causes a reduction in T2* relaxation time as well as phase differences between the vessel and its surrounding parenchyma 27. Oxygen saturation, integrity of red blood cells, and hematocrit levels are responsible for the T1 and T2 properties of blood.…”

mentioning

confidence: 99%

Susceptibility weighted imaging at 1.5 Tesla magnetic resonance imaging in dogs: Comparison with T2*‐weighted gradient echo sequence and its clinical indications

Weston

Morales²,

Dunning

et al. 2020

Vet Radiology Ultrasound

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Susceptibility weighted imaging (SWI) is a high resolution, fully velocity‐compensated, three‐dimensional gradient echo (GE) MRI technique. In humans, SWI has been reported to be more sensitive than T2*‐weighted GE sequences in the identification of both intracranial hemorrhage and intra‐vascular deoxyhemoglobin. However, published clinical studies comparing SWI to T2*‐weighted GE sequences in dogs are currently lacking. The aim of this retrospective, observational study was to compare SWI and T2*‐weighted GE sequences in a group of dogs with intracranial disease. Medical records were searched for dogs that underwent a brain MRI examination that included T2*‐weighted GE and SWI sequences. The presence and appearance of non‐vascular and vascular signal voids observed on T2*‐weighted GE and SWI were compared. Thirty‐two dogs were included with the following diagnoses: presumed and confirmed intracranial neoplasia (27), cerebrovascular accidents (3), and trauma (2). Hemorrhagic lesions were significantly more conspicuous on SWI than T2*‐weighted GE sequences (P < .0001). Venous structures were well defined in all SWI sequences, and poorly defined in all dogs on T2*‐weighted GE. Susceptibility weighted imaging enabled identification of vascular abnormalities in 30 of 32 (93.8%) dogs, including: neovascularization in 19 of 32 (59.4%) dogs, displacement of perilesional veins in five of 32 (15.6%) dogs, and apparent dilation of perilesional veins in 10 of 32 (31.3%) dogs. Presence of neovascularization was significantly associated with T1‐weighted post‐contrast enhancement (P = .0184). Hemorrhagic lesions and venous structures were more conspicuous on SWI compared to T2*‐weighted GE sequences. Authors recommend adding SWI to standard brain protocols in dogs for detecting hemorrhage and identifying venous abnormalities for lesion characterization.

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“…2). According to the previous literature [3, 4], the lesion was considered a microhemorrhage. From the present history, results of the examination of eye movement, and MRI imaging, he was diagnosed with traumatic MLF syndrome.…”

Section: Case Reportmentioning

confidence: 99%

A Case of Traumatic Medial Longitudinal Fasciculus Syndrome Whose Causal Lesion Was Detected by Thin-Section MRI with Susceptibility-Weighted Imaging

Ueno¹,

Honda²

2022

Case Rep Ophthalmol

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The aim of the study was to report a case of traumatic medial longitudinal fasciculus (MLF) syndrome diagnosed with brain magnetic resonance imaging (MRI) after a head injury. A 71-year-old male complained of diplopia after he was bruised the back of his head when he was hit by a bicycle and fell down. He showed failure of adduction in the right eye, and mild nystagmus was found in the left eye when looking to the left. Convergence was intact. A low-intensity area was found at the middle right site in the lower part of the midbrain using thin-section MRI with susceptibility-weighted imaging (SWI), which suggested a hemorrhage. From the present history, characteristic abnormality of eye movement, and MRI imaging, he was diagnosed with traumatic MLF syndrome. His symptom was resolved, and the eye movement was improved in 2 weeks. A hemorrhage that occurs in the brainstem may be a cause of traumatic MLF syndrome which could be detected by thin-slice MRI with SWI.

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A Case of Traumatic Unilateral Internuclear Ophthalmoplegia: Clinical Significance of Susceptibility-Weighted Imaging

Cited by 5 publications

References 17 publications

Three-Dimensional Identification of the Medial Longitudinal Fasciculus in the Human Brain: A Diffusion Tensor Imaging Study

Three-Dimensional Identification of the Medial Longitudinal Fasciculus in the Human Brain: A Diffusion Tensor Imaging Study

Susceptibility weighted imaging at 1.5 Tesla magnetic resonance imaging in dogs: Comparison with T2*‐weighted gradient echo sequence and its clinical indications

A Case of Traumatic Medial Longitudinal Fasciculus Syndrome Whose Causal Lesion Was Detected by Thin-Section MRI with Susceptibility-Weighted Imaging

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