A case of thyroid-type papillary carcinoma derived from ovarian mature cystic teratoma, resected by laparoscopic surgery

Abstract

Follicular variant thyroid-type papillary carcinoma (FVTPC) arising from thyroid tissue in mature cystic teratoma of the left ovary is extremely rare, and it is not easy to diagnose preoperatively. However, with reports of an early postoperative death, we must prudently select the strategy for this lesion. A 50-year-old woman had a uterine fibroid with hypermenorrhea and a left ovarian tumor measuring approximately 8 cm diameter. Serum thyroid-stimulating hormone level was within the normal limit. A laparoscopic hysterectomy and left salpingo-oophorectomy were performed. During surgery, there were no signs of invasion or metastasis, and there was no spillage in the abdomen. On histopathological examination of the left ovary, we diagnosed FVTPC arising from thyroid tissue in mature cystic teratoma of the left ovary. FVTPC in ovarian struma is a rare malignant transformation. We must be aware of the possibility of such a rare malignant disease when treating teratoma laparoscopically.

Live birth following laparoscopic fertility‑sparing surgery for papillary thyroid carcinoma arising from mature ovarian cystic teratoma: A case report

“…Papillary thyroid cancer arising from mature cystic teratoma is a rare occurrence, with an estimated incidence of 0.1–0.3% ( 18 ), with 11 cases in total reported in the literature to date ( 5 , 7 – 16 ), among which only 5 were patients of reproductive age ( 5 , 7 – 10 ) according to a search of the English literature on PubMed and MEDLINE. In patients of reproductive age, including the case in the present study ( 5 , 7 – 10 ), the mean age and tumor size were 29.2 years (range, 19–39 years) and 8.62 cm (range, 4.2–15 cm), respectively.…”

“…The most common malignant tumor in mature cystic teratomas is squamous cell carcinoma, whereas papillary thyroid carcinoma arising from mature cystic teratoma is extremely rare ( 6 ), with only 11 such cases documented in the English literature to date ( 5 , 7 – 16 ). In the majority of the cases, malignant transformation is diagnosed on postoperative pathological examination.…”

Tall cell variant of papillary carcinoma arising from strumaovarii: A rare case report

“…Malignant transformation of strumaovariioccurs rarely [1] and thyroid-type papillary carcinoma arising from thyroid tissue in mature cystic teratoma of the ovary is extremely rare. [1,2] The criteria for the histopathologic diagnosis of malignant carcinoma are usually adopted for the diagnosis of thyroidtype carcinoma arising in strumaovarii. [3,4] Strict criteria are required for the diagnosis of thyroid-type carcinoma because proliferative changes, including areas of densely packed follicles or pseudopapillary formations in strumaovarii may be confused with malignancy.…”