A Case of Thrombotic Thrombocytopenic Purpura and ST-Elevation Myocardial Infarction: An Unusual Correlation

Omole, Adekunle E; Ali, Azka; Ogunniyi, Kayode E; Waqar, Danish; Tobalesi, Opeyemi; Rahim, Omar; Awosika, Ayoola

doi:10.7759/cureus.36039

Cited by 3 publications

(3 citation statements)

References 14 publications

(17 reference statements)

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“…This finding is consistent with prior investigations that suggest CTS is more widespread and severe among the elderly [ 11 - 13 ] where the few previous population-based studies of CTS suggest a bimodal age distribution with a peak between ages 50 and 54 years, and a second peak between 75 and 84 years [ 11 ]. Potential contributors to the elevated severity scores include age-related alterations in tissues and an elevated probability of comorbidities among the elderly [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence, Awareness, and Management of Carpal Tunnel Syndrome Among Diabetic Patients

Abuharb,

Almughira,

Alghamdi

et al. 2024

Cureus

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Background: Carpal tunnel syndrome (CTS) is a common condition that can significantly affect the quality of life for individuals, particularly those with diabetes. This study aims to examine the severity of CTS symptoms among diabetic patients and explore the associations between demographic factors, diabetic characteristics, knowledge, and management approaches.Methodology: A cross-sectional study was conducted among diabetic patients, and data were collected using standardized questionnaires. The incidence and severity of CTS were assessed using the Boston Carpal Tunnel Questionnaire (BCTQ). Demographic information, diabetic characteristics, knowledge of CTS, and management approaches were also recorded. Descriptive statistics and inferential analysis were performed to analyze the data.Results: The study included 303 participants. The majority of the participants were aged 50 or older (44.9%) (N=136), followed by those aged 39-49 (24.4%) (N=74). In terms of gender, there were more female participants (61.4%) (N=186) than male participants (38.6%) (N=117). Older age groups exhibited higher mean BCTQ scores, suggesting increased severity. Females had significantly higher severity scores compared to males (mean BCTQ score of 17.52 vs 15.56). Regarding diabetic characteristics, complications in the eye and pain/numbness in the legs or feet were significantly associated with higher severity scores of CTS (P=0.0001). The study revealed a knowledge gap among diabetic patients about CTS, with inadequate knowledge about its causes, symptoms, consequences, and treatment options among 68.6% of the patients. The use of medical interventions such as splints, injections, and surgery was associated with higher severity scores.Conclusion: This study highlights the incidence and severity of CTS symptoms among diabetic patients and its associations with demographic factors, diabetic characteristics, knowledge, and management approaches. Older age, female gender, widowed, diabetic complications in the eye, and pain/numbness in the legs or feet were found to be related to increased severity of CTS. Additionally, inadequate knowledge about CTS was observed among diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Prevalence, Awareness, and Management of Carpal Tunnel Syndrome Among Diabetic Patients

Abuharb,

Almughira,

Alghamdi

et al. 2024

Cureus

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“…AMI has been associated with TTP, with reported incidence rate varying between 15% and 41% [6,8] . Reported cases of AMI induced by TTP [4,[9][10][11][12][13][14][15][16][17][18][19][20] are summarized in Table 3. A large national database of 4,032 patients with TTP [21] reported 11.1% in-hospital mortality and 5.7% AMI rate.…”

Section: Discussionmentioning

confidence: 99%

Acute myocardial infarction in a patient with thrombotic thrombocytopenic purpura: a case report and literature review

Hu,

Chen,

Yuan

et al. 2023

Cardiology Plus

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Acute myocardial infarction (AMI) induced by thrombotic thrombocytopenic purpura (TTP) has been previously reported, but comorbidity with autoimmune hemolytic anemia is rare. The index patient, a 55-year-old woman, presented with acute ST-elevation myocardial infarction (STEMI). A diagnosis of TTP was established on the presence of thrombocytopenia, microangiopathic hemolytic anemia, acute kidney injury, fever, and neurologic symptoms (ischemic stroke); autoimmune hemolytic anemia was established based on Comboost test. Percutaneous coronary intervention and dual antiplatelet therapy were not initiated due to elevated risk of bleeding. Instead, the patient was treated with glucocorticosteroid and plasmapheresis. Despite the treatment, the patient suffered a watershed acute cerebral infarction, and finally died of gastrointestinal bleeding. This case highlights the challenges in managing STEMI in TTP patients.

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“…This might be complicated by ischemic injury of the nerve microcirculation. Consequently, a range of neurologic symptoms occurs along the palmar distribution of the median nerve in the hand [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Awareness of Carpal Tunnel Syndrome Among Adults in Tabuk City of Saudi Arabia: A Cross-Sectional Study

Mirghani,

Aljohani,

Alharbi

et al. 2024

Cureus

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Background Carpal Tunnel Syndrome (CTS) is a condition when the median nerve is entrapped and compressed within the wrist. It significantly affects the quality of life and work productivity of the affected individuals. Aim This study aimed to assess the prevalence of CTS and the risk factors associated with this condition among the general population in Tabuk City, Saudi Arabia, and to explore their knowledge of the causes, manifestations, and treatment options. Methods This cross-sectional study included male and female adult residents of Tabuk City aged 18 years and above who agreed to participate in the study. Data were collected using an online, self-administered questionnaire that was distributed to the public using different social media platforms. Results In this study, the prevalence of CTS was 3.4%. The presence of chronic diseases was a significant risk factor for the CTS (p = 0.003). Participants having chronic diseases were 6.370 times more likely to develop CTS (AOR: 6.370, 95% CI: 2.048 to 19.817). The participants had good levels of awareness about the causes (89.3%), clinical manifestations, and treatment of CTS (92.2%). There was a significant association between the level of knowledge about the causes of CTS and gender (p=0.014). Females (74.3%) showed a higher level of knowledge than males (25.7%). As well, the young (18-25) age group (67.9%) was more significantly aware of the causes of CTS in comparison to the other age groups (p=0.023). Conclusion The prevalence of carpal tunnel syndrome among the adult population in Tabuk City, Saudi Arabia, was 3.4%, and the significant underlying risk factors were chronic diseases such as diabetes mellitus, hypothyroidism, and rheumatoid arthritis. The level of awareness of CTS was satisfactory.

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A Case of Thrombotic Thrombocytopenic Purpura and ST-Elevation Myocardial Infarction: An Unusual Correlation

Cited by 3 publications

References 14 publications

Prevalence, Awareness, and Management of Carpal Tunnel Syndrome Among Diabetic Patients

Prevalence, Awareness, and Management of Carpal Tunnel Syndrome Among Diabetic Patients

Acute myocardial infarction in a patient with thrombotic thrombocytopenic purpura: a case report and literature review

Prevalence and Awareness of Carpal Tunnel Syndrome Among Adults in Tabuk City of Saudi Arabia: A Cross-Sectional Study

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