A case of thrombocytopenia caused by rifampicin and pyrazinamide

Abstract

A 32-year-old male patient was diagnosed as having pulmonary tuberculosis and put on category II antitubercular regime since he had a history of antituberculosis treatment 10 years ago. Within 3 weeks, patient presented with ulcers in mouth, and blood picture confirmed thrombocytopenia. Rifampicin-induced thrombocytopenia was suspected and antitubercular treatment stopped. Patient improved and was re-exposed to the drugs one by one. After re-exposure with pyrazinamide, the platelet count decreased drastically and oral mucosal ecchymoses reappeared, while with rifampicin, thrombocytopenia was accompanied with petechiae on legs and forearms. Isoniazid, ethambutol, and streptomycin were continued.

A case of thrombocytopenia associated with the use of hydroxychloroquine following open heart surgery

“…However, immune-mediated thrombocytopenia is not dose-dependent and the diagnosis is challenging; the reason is that these patients use multiple medications. 7 …”

Synthesis, Characterization and Antioxidant Activity of Some Transition Metal Complexes With Terpenoid Derivatives

“…Ligands were prepared by method reported earlier. 24,42 Metal contents were measured by complexometric titration 48 . Sulfur was estimated gravimetrically as BaSO 4 and chloride content was determined by Volhard's Methods.…”

“…In the spectrum of TBHSC amide (C=O) band observed at 1698 cm -1 is shifted to lower frequency due to coordination of amido oxygen to metal ion 24 . The ligand TBHTSC shows band at 875 cm -1 which shifted to the downward region in the complexes suggests the coordination of metal ion through the C=S group 24 . The spectra of both ligands exhibit a band in the 1553-1580 cm -1 region due to C=N mode of azomethine linkage.…”

“…The spectra of both ligands exhibit a band in the 1553-1580 cm -1 region due to C=N mode of azomethine linkage. In the metal complexes this band shifted to lower frequency suggesting that the unsaturated nitrogen of azomethine linkage is coordinated to metal 24,42 . In ligands the highest frequency bands observed in 3425-3455 cm -1 and 3225-3260 cm -1 regions are assigned to asymmetric and symmetric stretching of terminal NH 2 group vibration.…”

“…[21][22][23] Previously, we have reported the structural and spectral studies of transition metal complexes of some acyclic monoterpenic constituents of essential oils. 24,25 Our ongoing research work on transition metal complexes with semicarbazones and thiosemicarbazones involving such systems led us to describe the synthesis, characterization and antioxidant activity of some transition metal complexes with semicarbazone and thiosemicarbazone derived from camphor (1,7,7-trimethylbicyclo [2,2,1] heptane-2-one). Camphor is a bicyclic monoterpenone and important constituent of several essential oils, e.g.…”