A case of thalassaemia major with gross dental and jaw deformities

Skeletal facial deformity in patients with β thalassemia major: Report of one Tunisian case and a review of the literature

“…Since 1969, there have only been 12 reported cases of surgical intervention of thalassemia-induced facial deformities [1,5,7,8,10].…”

“…b Thalassemia syndromes are part of a larger group of inherited hematologic disorders known as hemoglobinopathies [1]. They result from a wide variety of genetic defects and produce diverse clinical findings, from subtle morphologic abnormalities to lifethreatening disease [2].…”

Dental considerations in Thalassemic patients

“…Malocclusion due to maxillary protrusion, increased overjet and anterior open bite, malar prominence, saddle nose and frontal bossing give an appearance of 'chip-munk facies' or rodent facies' [7]. (Fig3,4) The mandible is generally less protruded than maxilla apparently because the dense mandibular cortical layer resists expansion [8]. Overgrowth of marrow in frontal, temporal and facial bones consistently impedes pneumatisation of paranasal sinuses [9].…”

Β Thalassemia; A Case Report of Oral and Maxillofacial Manifestation From Population of Karachi Pakistan

“…The bony changes may occur early in life and tend to persist, particularly in skull. 16,25,32,36 Furthermore tint of lemon color is observed in oral mucosa.…”

“…[17][18][19]23,25,33,[28][29][30][31][32][33][34][35][36] Under the influence of the disorder the typical facial appearance develops; high and bulging cheek bones, retraction of the upper lip, protrusion of the anterior teeth and spacing in other teeth, over-bite or open-bite, and varying degrees of malocclusion. The skeletal changes are the result of proliferation of the bone marrow in the facial skeleton.…”