A Case of Taxane-induced Onycholysis and Subungual Abscesses

Jin, Won; Jung, Jin Geol; Ro, Ki Woong; Shim, Sang Dai; Kim, Myung Hwa; Cinn, Yong Woo

doi:10.5021/ad.2007.19.1.28

Cited by 1 publication

(2 citation statements)

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“…But the most prominent theory is the direct paclitaxel-induced nail bed damage as previously described. 27 The National Cancer Institute (NCI) has graded the effect of chemotherapeutic agents on nails into 3 grades in which grade 1 represents nail discoloration associated with pitting or ridging of nails, whereas grade 2 represents a total or partial loss of nail, but when there is a complete or partial loss of nail accompanied with pain that interferes with the normal nail functionalities, it is considered as grade 3. 28 According to the literature, several case reports have discussed the effect of taxanes on nails.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Nail Lacquer on Taxane-Induced Nail Changes in Women With Breast Cancer

Alshari

Aleshawi

Sharie

et al. 2020

Breast Cancer�(Auckl)

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Objective: Taxane-induced nail changes are considered as an important cosmetic manifestation with an incidence that reaches up to 44% of patients treated with taxane-included therapeutic regimens. In this article, we represent a clinical observational study to evaluate the effect of cosmetic nail lacquer on taxane-induced nail changes in female patients diagnosed with breast cancer. Methods: Prospectively, we identified those women who were diagnosed with breast cancer, scheduled to have AC-Taxol protocol. Any female with previous dermatological or systemic disorders that affect nails was excluded from the study. Patients were categorized into 2 groups based on the utilization of nail lacquer. The first group includes women who started to use the nail lacquer after development of nail changes. The second group comprises those women who did not use the nail lacquer at any occasion. Results: A total of 59 female patients were included in the study; 46 (78%) of them developed nail changes and the main change was nail discoloration. The first group which has used nail lacquer (17, 28.8%) showed an improvement among 15 (78.9%) patients, whereas 2 (7.4%) of them continued to have worsening symptoms. On the contrary, most of the second group (25, 92.9%) did not show any improvement in nail changes. A statistical significance between the tested groups was observed ( P = .000). There is no statistical association between the progression of nail changes and the age of patients. Conclusions: Taxane-induced nail changes are considered as an important clinical, cosmetic, and psychological complication, especially for female patients with cancer. This article suggests that nail lacquer may have an effect in the improvement of nail changes, especially nail discoloration. Further investigations are recommended to prove the efficacy of nail lacquer.

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Section: Discussionmentioning

confidence: 99%

“…But the most prominent theory is the direct paclitaxel-induced nail bed damage as previously described. 27…”

Section: Discussionmentioning

confidence: 99%