A Case of Tardive Dystonia Successfully Managed With Quetiapine

Sasaki, Yukiya; Kusumi, Ichiro; Koyama, Tsukasa

doi:10.4088/jcp.v65n0420e

Cited by 14 publications

(8 citation statements)

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“…Both dyskinesia and dystonia in our patient were improved by switching from aripiprazole to quetiapine therapy. Switching to quetiapine from other SGA also improved dyskinesia or dystonia in several previous case reports (19–22). Our results seem to support the findings of the previous reports.…”

Section: Discussionsupporting

confidence: 55%

Improvement of tardive dyskinesia and dystonia associated with aripiprazole following a switch to quetiapine: case report and review of the literature

Ono

Suzuki

Shindo

et al. 2011

Journal of Clinical Pharmacy and Therapeutics

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There were several previous case reports on dyskinesia and dystonia associated with aripiprazole medication. The risk factors for tardive dyskinesia include older age and female sex. However, our case was a male patient who was younger compared with the previous cases and so should have been less at risk for dyskinesia in comparison with the previous cases. The effects of aripiprazole can include tardive movement disorders. Dyskinesia, dystonia and psychotic symptoms were improved with relatively small dose of quetiapine in this case. Whether some second-generation antipsychotics are more effective than others in the treatment of tardive dyskinesia remains unclear.

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Section: Discussionsupporting

confidence: 55%

Improvement of tardive dyskinesia and dystonia associated with aripiprazole following a switch to quetiapine: case report and review of the literature

Ono

Suzuki

Shindo

et al. 2011

Journal of Clinical Pharmacy and Therapeutics

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“…To our knowledge there has been only a case report about the use of quetiapine in the treatment of TD, 11 1 in the treatment of torticollis, 12 and several others in the treatment of TD. 13 Although atypical antipsychotics other than clozapine have been also used in the management of TD, 14 there have been several reports about risperidone-15 and olanzapineinduced TD.…”

Section: Discussionmentioning

confidence: 93%

Quetiapine in the Treatment of Focal Tardive Dystonia Induced by Other Atypical Antipsychotics

Gourzis¹,

Polychronopoulos²,

Papapetropoulos³

et al. 2005

Clinical Neuropharmacology

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The authors report 2 patients with schizophrenia who developed focal tardive dystonia secondary to treatment with atypical antipsychotics (risperidone, olanzapine). When quetiapine was gradually introduced and other antipsychotics were discontinued, these patients experienced remarkable and sustained improvement of their dystonic symptoms, without loss of psychotic symptom control. The mechanism by which quetiapine may improve tardive dystonia caused by other atypical antipsychotics is unclear. Due to its receptor and pharmacologic profile, quetiapine is the atypical antipsychotic that is most similar to clozapine (without its hematologic side effects), which leads the authors to consider it for the treatment of tardive movement disorders.

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“…Quetiapine-related TD was noted and described in an early case report about 15 years ago 5). However, some reports also mention contrary findings of quetiapine's ability to relieve TD 1,2,8,9,10,11,12,13). Emsley et al14) found that quetiapine could effectively reduce TD severity in patients with established TD, but the mechanism of this action is unclear.…”

Section: Discussionmentioning

confidence: 99%

Late-onset Quetiapine-related Tardive Dyskinesia Side Effects in a Patient with Psychotic Depression

Hou

Lai

2014

Clin Psychopharmacol Neurosci

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The atypical antipsychotics were believed to induce less extrapyramidal syndrome, including tardive dyskinesia (TD). Since the introduction of the quetiapine, it is also reported with less TD side effects. It even can relieve the symptoms of severe TD and reduce the risk of TD. The quetiapine's low affinity and fast dissociation from postsynaptic dopamine D2 receptors should give the least risk of producing the symptoms of TD. The quetiapine even can reduce the TD side effects related to clozapine, which has the lowest risk for TD. However, since the first case report of TD side effects related to quetiapine published on 1999, the safety of quetiapine in TD aspect has been questioned. Therefore, we want to share this case report, which was written to describe the severe late-onset TD side effects after long-term use of quetiapine in a patient with psychotic depression. The patient had no significant findings after concurrent comprehensive neurological examinations, magnetic resonance imaging of brain and electroencephalogram since the onset of TD.

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A Case of Tardive Dystonia Successfully Managed With Quetiapine

Cited by 14 publications

References 0 publications

Improvement of tardive dyskinesia and dystonia associated with aripiprazole following a switch to quetiapine: case report and review of the literature

Improvement of tardive dyskinesia and dystonia associated with aripiprazole following a switch to quetiapine: case report and review of the literature

Quetiapine in the Treatment of Focal Tardive Dystonia Induced by Other Atypical Antipsychotics

Late-onset Quetiapine-related Tardive Dyskinesia Side Effects in a Patient with Psychotic Depression

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