A case of Takotsubo cardiomyopathy with COVID 19

Nguyen, Damien; Nguyen, Thomas; Bels, David De; Rodriguez, José Castro

doi:10.1093/ehjci/jeaa152

Cited by 41 publications

(53 citation statements)

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“…Takotsubo cardiomyopathy, a reversible condition, occurs due to physical and emotional stress that affects the left ventricle. Several reports have shown Takotsubo cardiomyopathy in COVID-19 patients (180)(181)(182)(183)(184)(185). Correspondingly, this condition is also reported in influenza-infected patients (186)(187)(188)(189).…”

Section: Comparison Of Cardiovascular Conditions Associated With Sarsmentioning

confidence: 73%

Immune Mechanisms in Cardiovascular Diseases Associated With Viral Infection

2020

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Influenza virus infection causes 3-5 million cases of severe illness and 250,000-500,000 deaths worldwide annually. Although pneumonia is the most common complication associated with influenza, there are several reports demonstrating increased risk for cardiovascular diseases. Several clinical case reports, as well as both prospective and retrospective studies, have shown that influenza can trigger cardiovascular events including myocardial infarction (MI), myocarditis, ventricular arrhythmia, and heart failure. A recent study has demonstrated that influenza-infected patients are at highest risk of having MI during the first seven days of diagnosis. Influenza virus infection induces a variety of pro-inflammatory cytokines and chemokines and recruitment of immune cells as part of the host immune response. Understanding the cellular and molecular mechanisms involved in influenza-associated cardiovascular diseases will help to improve treatment plans. This review discusses the direct and indirect effects of influenza virus infection on triggering cardiovascular events. Further, we discussed the similarities and differences in epidemiological and pathogenic mechanisms involved in cardiovascular events associated with coronavirus disease 2019 (COVID-19) compared to influenza infection.

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Section: Comparison Of Cardiovascular Conditions Associated With Sarsmentioning

confidence: 73%

Immune Mechanisms in Cardiovascular Diseases Associated With Viral Infection

2020

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“…Our search identified 25 articles; 9 were excluded due to duplication, 5 were excluded because they were review articles on COVID-19, and did not report any cases with TTS. Finally, 10 articles describing 12 patients for the analysis were selected [9][10][11][12][13][14][15][16][17][18] (Tables 1 and 2). The mean age of the reported patients was 70.8 ± 15.2 years (range 43-87 years).…”

Section: Resultsmentioning

confidence: 99%

Takotsubo Syndrome in Patients with COVID-19: a Systematic Review of Published Cases

Singh¹,

Desai

Gandhi

et al. 2020

SN Compr. Clin. Med.

112

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Takotsubo syndrome (TTS) is caused by catecholamine surge, which is also observed in COVID-19 disease due to the cytokine storm. We performed a systematic literature search using PubMed/Medline, SCOPUS, Web of Science, and Google Scholar databases to identify COVID-19-associated TTS case reports and evaluated patient-level demographics, clinical attributes, and outcomes. There are 12 cases reported of TTS associated with COVID-19 infection with mean age of 70.8 ± 15.2 years (range 43–87 years) with elderly (66.6% > 60 years) female (66.6%) majority. The time interval from the first symptom to TTS was 8.3 ± 3.6 days (range 3–14 days). Out of 12 cases, 7 reported apical ballooning, 4 reported basal segment hypo/akinesia, and 1 reported median TTS. Out of 12 cases, during hospitalization, data on left ventricular ejection fraction (LVEF) was reported in only 9 of the cases. The mean LVEF was 40.6 ± 9.9% (male, 46.7 ± 5.7%, and female, 37.7 ± 10.6%). Troponin was measured in all 12 cases and was elevated in 11 (91.6%) without stenosis on coronary angiography except one. Out of 11 cases, 6 developed cardiac complications with 1 case each of cardiac tamponade, heart failure, myocarditis, hypertensive crisis, and cardiogenic shock in 2. Five patients required intubation, 1 patient required continuous positive airway pressure, and 1 patient required venovenous extracorporeal membrane oxygenation. The outcome was reported in terms of recovery in 11 (91.6%) out of 12 cases, and a successful recovery was noted in 10 (90.9%) cases. COVID-19-related TTS has a higher prevalence in older women. Despite a lower prevalence of cardiac comorbidities in COVID-19 patients, direct myocardial injury, inflammation, and stress may contribute to TTS with a high complication rate.

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“…Cardiac dysfunction with associated pulmonary edema (i.e., myocarditis, arrhythmias, and stress cardiomyopathy) has been previously reported in COVID-19. 27 − 33 Although the occurrence of severe ADEM in COVID-19 has not been linked necessarily to lung pathology, 7 neurogenic pulmonary edema due to the catecholamine storm after a severe brain injury in COVID-19 cannot be excluded as a clinical entity. In our prospective lung ultrasound study of severe COVID-19 pneumonia, we have encountered interstitial pulmonary edema in variable lung and pleural zones of distribution.…”

Section: An Emerging Hypothesismentioning

confidence: 99%

Lung Injury in COVID-19—An Emerging Hypothesis

Alharthy

Faqihi

Memish

et al. 2020

ACS Chem. Neurosci.

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Lung injury with COVID-19 may be due to a complex underlying pathophysiology. Cytokine release syndrome appears to be a catalyst of different inflammatory pathways promoting lung parenchymal injury and thromboembolic phenomena (“dual hit” injury). Recently, severe neurological manifestations such as acute disseminated encephalomyelitis, which may be not linked to lung pathology, have been identified in COVID-19, contributing thus further to the versatility of its clinical features.

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A case of Takotsubo cardiomyopathy with COVID 19

Cited by 41 publications

References 0 publications

Immune Mechanisms in Cardiovascular Diseases Associated With Viral Infection

Immune Mechanisms in Cardiovascular Diseases Associated With Viral Infection

Takotsubo Syndrome in Patients with COVID-19: a Systematic Review of Published Cases

Lung Injury in COVID-19—An Emerging Hypothesis

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