A case of T-cell large granular lymphocytic leukemia

Takahashi, A.

doi:10.26226/morressier.596dfd58d462b80292387b00

Cited by 2 publications

(2 citation statements)

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“…For example, one study demonstrated doxorubicin simply mixed with a nanosilicate suspension allowed for doxorubicin binding or encapsulation through ion exchange in the interlayered space of the dispersed nanosilicates. 30,46 Intriguingly, even nonionic drugs such as dexamethasone have also recently been immobilized on nanosilicates. 20 In addition to binding efficiency, the retained structure of the bound protein or therapeutic is essential as the protein corona of the nanoparticle will direct subsequent uptake or delivery.…”

Section: Resultsmentioning

confidence: 99%

Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates

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Ding

et al. 2019

ACS Appl. Mater. Interfaces

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We present a nanoengineered system for sustained and prolonged delivery of protein therapeutics, which has the potential to impact current orthopedic regeneration strategies. Specifically, we introduce two-dimensional nanosilicates with a high surface area and charged characteristics for delivery of active proteins for more than 30 days. The nanosilicates show high binding efficacy without altering the protein conformation and bioactivity. The released proteins are able to maintain high activity as demonstrated by enhanced differentiation of human mesenchymal stem cells at 10-fold lower concentration compared to the exogenous control. Utilizing the nanosilicates as a delivery vehicle could minimize the negative side effects observed because of the use of supraphysiological dosages of protein therapeutics for orthopedic regeneration strategies.

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Section: Resultsmentioning

confidence: 99%

Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates

Cross

Carrow

Ding

et al. 2019

ACS Appl. Mater. Interfaces

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“…In the same years, Japanese researchers developed synthetic sapphire (alumina single crystal) dental implants that were manufactured by Kyocera and were in clinical use in Japan since 1972, and in the United States since 1980 [9]. Takahashi et al [10] reported the follow-up of a series of 65 tap-type porous sapphire dental implants, three of them still in place after 21-23 years. Notwithstanding some clinical success the alumina dental implants never had a large diffusion, because of the limitation in design imposed by the intrinsic brittle mechanics of fracture of alumina and of the limits in stability due only to mechanical interlock with the host bone.…”

Section: Introductionmentioning

confidence: 99%

New Materials for Dental Implantology

Piconi

Sandri

2017

KEM

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Metal-free implantology with zirconia devices is a relatively new technology. Nevertheless, more and more patients demand this kind of implant in place of the ones made out titanium due to the better aesthetics, lower risk of perimplantitis, concerns about metallic ions release. This paper analyze concisely the present situation of zirconia dental implants, and overviews the developments in progress on devices made out alumina/zirconia composites that will likely replace zirconia in the next future. Besides ceramics, Polyetheretherketone (PEEK) is now proposed for metal-free dentistry, the ceramic-loaded formulation of this high-performance polymer are especially interesting for dental implantology.

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A case of T-cell large granular lymphocytic leukemia

Cited by 2 publications

References 0 publications

Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates

Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates

New Materials for Dental Implantology

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