A case of systemic lupus erythematosus showing acute gangrenous change of fingertips

Yang, Solmon; Kim, K. H.; Park, K. C.; Youn, So Won; Joh, Gwang Yeol

doi:10.1111/j.1365-2133.1996.tb07870.x

Cited by 10 publications

(3 citation statements)

References 7 publications

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“…Rosato et al 12 had even asserted that digital ulcers and gangrene are never present as initial manifestation in SLE. However, Yang et al 13 had reported a case of acute gangrene of finger in an 8-year-old Korean girl without prior features of SLE. Cheah14 had also reported a 33-year-old Chinese woman presenting with digital gangrene 3 weeks after the diagnosis of SLE.…”

Section: Introductionmentioning

confidence: 99%

Digital gangrene as the initial presentation of systemic lupus erythematosus

2012

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SummarySystemic lupus erythematosus (SLE) has rarely been reported among African blacks. However, recent reports may indicate otherwise. Digital gangrene in lupus patients has been reported in different populations and has mostly been seen in patients with long-standing lupus. Digital gangrene as the initial presentation of SLE has rarely been reported, even among African blacks. Two cases of digital gangrene as the initial presentation in Nigerian lupus patients are hereby presented. The medical and surgical managements, as well as relevant literature are hereby discussed. BACKGROUND

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Section: Introductionmentioning

confidence: 99%

Digital gangrene as the initial presentation of systemic lupus erythematosus

2012

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“…Du Bois and Arterberry 13 had, many years previously, estimated the incidence of limb gangrene in SLE to be 1.3%. Yang et al 14 . in their paper on gangrene and SLE in 1996 were able to find only 14 such cases in the literature commencing with the Alarcon‐Segovia paper.…”

Section: Incidence Of Gangrene In Slementioning

confidence: 99%

Peripheral Vascular Occlusions Leading to Gangrene and Amputations in Antiphospholipid Antibody Positive Patients

Asherson

Cervera

Shoenfeld

2007

Annals of the New York Academy of Sciences

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Twenty-one cases from several medical centers (Brazil, Italy, Serbia, South Africa, Israel, and the United Kingdom) with severe peripheral vascular disease progressing to amputations of limbs/digits, all of whom tested positive for antiphospholipid antibodies, are documented. The patients were suffering from either systemic lupus erythematosus, discoid LE, "primary" antiphospholipid syndrome (PAPS), "lupus-like" disease, undifferentiated connective tissue disease. A high frequency of livedo reticularis preceding the arterial occlusions in our series of patients who subsequently progressed to ischemic necrosis and amputation of limbs/digits was noted. Five of the 10 patients, in whom histopathological studies had been performed, demonstrated the typical vasculopathy seen with the antiphospholipid syndrome ("APS vasculopathy"). Complicating vasculitis was present in seven of the patients. Five of the patients developed severe peripheral vascular disease during the course of the catastrophic antiphospholipid (Asherson's) syndrome.

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“…In several studies on SLE in children, gangrene and Raynaud phenomenon have been described as a rare manifestation of SLE [1–5]. In adult patients with SLE, these rare symptoms have been described as the presenting symptoms [6,7], but they have not been described as the first and only presenting symptoms of systemic lupus erythematosus in children, although there is 1 report in the literature showing peripheral gangrene as the presenting symptom in infancy [8]. We present the case of a girl referred to our center, presenting with peripheral gangrene plus Raynaud’s phenomenon, who proved to have SLE.…”

Section: Introductionmentioning

confidence: 99%

Peripheral gangrene: A rare presentation of systemic lupus erythematosus in a child

2013

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Patient: Female, 12Final Diagnosis: Antiphospholipid positive SLESymptoms: Gangrene • Raynaud’s phenomenon • autoamputation of the terminal phalanx of the second left hand fingerMedication: Prednisolone • mycophenolate mofetil • captoprilClinical Procedure: Renal Biopsy • treatment of lupus nephritis • control of hypertensionSpecialty: Pediatric rheumatologyObjective:Unusual clinical courseBackground:SLE in children has many manifestations. In several studies on SLE in children, gangrene and Raynaud phenomenon have been described as a rare manifestation of SLE during its course in children.Case Report:We present the case of a 12-year-old girl referred to our center, presenting with peripheral gangrene plus Raynaud’s phenomenon, who proved to have SLE. Our patient was treated with steroids and mycophenolate mofetil. She appeared to respond to this combination judging by the disappearance of the digital cyanosis, appearance of extremity pulses, and return of renal function.Conclusions:This case highlights the importance of precise management and awareness of very rare manifestations of a common disease like SLE. Gangrene can be initial symptom of SLE in children. We recommend SLE evolution in all children with gangrene symptom.

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A case of systemic lupus erythematosus showing acute gangrenous change of fingertips

Cited by 10 publications

References 7 publications

Digital gangrene as the initial presentation of systemic lupus erythematosus

Digital gangrene as the initial presentation of systemic lupus erythematosus

Peripheral Vascular Occlusions Leading to Gangrene and Amputations in Antiphospholipid Antibody Positive Patients

Peripheral gangrene: A rare presentation of systemic lupus erythematosus in a child

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