A case of synchronous isolated thyroid metastasis from a primary lung cancer presenting as thyroid primary: Diagnostic challenge!

Hulikal, Narendra; Naru, Ramana Reddy; Gangasani, Revanth; Rukmangadha, Nandyala; Pai, Ananth; Meenakshisundaram, Manickavasgam

doi:10.4103/0970-2113.180912

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…The most common metastases to the thyroid gland among lung cancers are respectively adenocarcinoma, squamous, small and large cell lung cancer. 7 Clinically, non-thyroidal metastases of the thyroid gland are rare, and most are found at autopsy. The proportion of thyroid metastatic lesions reported in vivo is 2-3% of all thyroid neoplasms as against approximately 1-24% reported in postmortem cases.…”

Section: Discussionmentioning

confidence: 99%

Akciğer Skuamöz Hücreli Karsinomlu Hastada Tiroid Metastazı Vakası

TOPÇU,

SÜLLÜ,

ÇALIŞKAN

et al. 2023

Turkiye Klinikleri Arch Lung

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Lung cancer is an important reason for mortality in developing and developed countries. It is the most widespread reason of cancer-related mortality in both genders worldwide. The regions where lung cancers frequently metastasize are the nervous, bone, liver, respiratory system, and adrenal glands. 1 Metastasis to the thyroid gland was first reported in 1871 by Virchow, who described a testicular tumor metastasis. 2 In the case report, a rare case of thyroid gland metastasis during the treatment of a patient with squamous cell lung cancer in our clinic is presented. CASE PRESENTATIONA forty-four-year-old male patient with no chronic disease was referred to the Chest Diseases outpatient clinic 2 years ago with complaints of cough, exertional dyspnea, and involuntary weight loss for the

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Section: Discussionmentioning

confidence: 99%

Akciğer Skuamöz Hücreli Karsinomlu Hastada Tiroid Metastazı Vakası

TOPÇU,

SÜLLÜ,

ÇALIŞKAN

et al. 2023

Turkiye Klinikleri Arch Lung

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“…It often metastasizes to the brain, bone, liver, lung, adrenal gland, etc. The metastases of lung cancer to the thyroid gland are rare [3]. Of the four types of lung cancer causing thyroid gland metastasis, adenocarcinomas are the commonest followed by squamous and large cell carcinomas.…”

Section: Introductionmentioning

confidence: 99%

A Case Report of Thyroid Gland Metastasis in Small Cell Lung Cancer

Yang

2018

J Med Cases

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Thyroid metastasis of small cell lung cancer is rare in clinic, and few cases have been reported so far. We reported one case of 61-year-old Chinese male patient who presented with a progressive enlargement of mass in the right thyroid gland for 1 month. It was confirmed later to be originating from a small cell lung cancer. Then the patient was given chemoradiotherapy, but still died 6 months later. Although thyroid gland metastasis in lung cancer is rare in clinic, it should not be misdiagnosed. The treatment of thyroid metastasis of small cell lung cancer is mainly chemoradiotherapy; long-term survival of thyroid metastasis remained worse.

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“…The metastases of a primary lung cancer to the thyroid gland are extremely rare [ 1 ]. The differential diagnosis with primary cancer of the thyroid is difficult because of the non-specific clinical symptoms and imaging [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Lung adenocarcinoma with thyroid metastasis: a case report

Dao

Jabir²,

Taleb³

et al. 2017

BMC Res Notes

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BackgroundThe metastases of a primary lung cancer over the thyroid gland are extremely rare. We report on an unusual presentation of thyroid metastasis of lung cancer in order to improve the management of similar cases.Case presentationThree years ago, a Moroccan male 59-year-old was admitted for dyspnea, dry cough, and chest pain. He had smoked about 30 cigarette packs a year. Clinical examination revealed a right thyroid nodule. Chest and neck computed tomography (CT) scan showed a proximal left tumor in contact with the pulmonary artery and revealed a suspected nodule in the right lobe of the thyroid with homolateral neck node. Transbronchial biopsy was performed and pathological examination revealed adenocarcinoma of the lung and positive for thyroid transcription factor. Other explorations carried out, such as brain CT, bone scan and abdominal ultrasound were normal. After a repeated negative fine needle aspiration biopsy of the suspected nodule of the right lobe of the thyroid, we performed total thyroidectomy with neck dissection. An anatomopathologic exam revealed a tubulopapillary adenocarcinoma poorly differentiated. An Immunohistochemistry showed positive tumor cells with TTF1 and cytokeratin (CK) 7 but negative cells with thyroglobulin and CK20. Thus, the pulmonary tumor was classified stage IV. Chemotherapy based on the combination of cisplatin and etoposide was conducted along with supportive care. The tumor grew up with brain metastases after three cycles of chemotherapy. Unfortunately, the patient died 2 months after despite brain radiotherapy.ConclusionWe presented a medical case of a patient with thyroid metastasis resulting from a pulmonary adenocarcinoma which has rapidly evolved to brain metastases. The prognosis was pejorative in our clinical case (5 months after admission).

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A case of synchronous isolated thyroid metastasis from a primary lung cancer presenting as thyroid primary: Diagnostic challenge!

Cited by 5 publications

References 11 publications

Akciğer Skuamöz Hücreli Karsinomlu Hastada Tiroid Metastazı Vakası

Akciğer Skuamöz Hücreli Karsinomlu Hastada Tiroid Metastazı Vakası

A Case Report of Thyroid Gland Metastasis in Small Cell Lung Cancer

Lung adenocarcinoma with thyroid metastasis: a case report

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