A case of successful pregnancy in a woman with systemic sclerosis treated with cyclosporin

Basso, Monica; Ghio, Massimo; Filaci, Gilberto; Setti, Maurizio; Indiveri, Francesco

doi:10.1093/rheumatology/keh319

Cited by 8 publications

(6 citation statements)

References 3 publications

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“…In four patients of three studies, CsA was withdrawn after remission of skin fibrosis and the clinical course was reported after withdrawal. 25 , 29 , 30 Three patients relapsed, one within 6 months, and CsA had to be re-started in all three patients. 29 , 30 The fourth patient remained in remission.…”

Section: Results Of the Systematic Literature Searchmentioning

confidence: 99%

“…25 , 29 , 30 Three patients relapsed, one within 6 months, and CsA had to be re-started in all three patients. 29 , 30 The fourth patient remained in remission. 25…”

Section: Results Of the Systematic Literature Searchmentioning

confidence: 99%

“… 24 Finally, 27 review articles were excluded, and the remaining 37 identified primary research articles were included into the analysis. 24 – 60 The 37 articles consisted of 19 case reports, 15 case series, 1 open-label, randomized controlled trial with a no-treatment arm (group I iloprost vs group II iloprost with low-dose CsA), one open-label, prospective study with a historical control group (CSA group vs historical placebo group of the chlorambucil trial), 61 and one retrospective study without control (patients received prednisolone (0.5 mg/kg/d) and tacrolimus; Table 1 ).…”

Section: Results Of the Systematic Literature Searchmentioning

confidence: 99%

“…25,29,30 Three patients relapsed, one within 6 months, and CsA had to be re-started in all three patients. 29,30 The fourth patient remained in remission. 25 Because of the spontaneous regression of skin fibrosis often seen in patients with SSc, treatment studies without control groups must be interpreted with caution.…”

Section: Davies Andmentioning

confidence: 99%

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Calcineurin inhibitors in systemic sclerosis – a systematic literature review

Hofmann

Ambühl

Jordan

et al. 2022

Therapeutic Advances in Musculoskeletal

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Objective: To review treatment effectiveness and adverse events of calcineurin inhibitors (CNIs) such as cyclosporin A (CsA) and tacrolimus in patients with systemic sclerosis (SSc). Methods: A systematic literature search was performed on PubMed and Web of Science using the predefined keywords ‘systemic sclerosis’, scleroderma, cyclosporin*, and tacrolimus. Articles were eligible for inclusion, if SSc patients had been treated with CNIs and data on treatment effects were available. Results: This systematic literature review identified 37 papers (19 case reports, 15 case series, 2 controlled studies, and 1 retrospective study) including 134 SSc patients treated with CNIs. In 34 of 37 papers, CsA was used. An improvement of skin fibrosis was observed in 77 of 96 (80.2%) patients using a wide variety of outcome measures and dose regimes. Both controlled studies showed significant improvements, one using a historical control group and one using a no-treatment control group. Improvement in pulmonary function tests (PFTs) occurred in 67.9% (19/28) of the patients who had reduced PFTs at baseline. In 58 (43.3%) cases, adverse renal events were reported, of which 7 (5.2%) were severe such as scleroderma renal crisis (SRC), CsA-associated nephropathy, or death by renal insufficiency. Adverse events led to dose reduction, treatment interruption, or withdrawal in 39 of 134 (29.1%). Conclusion: In this systematic literature review, signals for potential effectiveness of CsA for skin and pulmonary fibrosis were found, but the evidence level of the identified studies was too low to allow robust conclusions. Randomized controlled double-blind trials are needed to conclude on the effectiveness of CNIs in SSc. Renal toxicity of CNIs was confirmed in this review and needs to be considered in the design of such studies.

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Section: Results Of the Systematic Literature Searchmentioning

confidence: 99%

“…25 , 29 , 30 Three patients relapsed, one within 6 months, and CsA had to be re-started in all three patients. 29 , 30 The fourth patient remained in remission. 25…”

Section: Results Of the Systematic Literature Searchmentioning

confidence: 99%

Section: Results Of the Systematic Literature Searchmentioning

confidence: 99%

Section: Davies Andmentioning

confidence: 99%

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Calcineurin inhibitors in systemic sclerosis – a systematic literature review

Hofmann

Ambühl

Jordan

et al. 2022

Therapeutic Advances in Musculoskeletal

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“…Thus, nifedipine is regularly prescribed in women with SSc during pregnancy. Finally, Basso and Ghio reported the first case of successful pregnancy in a woman with SSc treated with cyclosporine [43]. A Japan team reported the case of a woman with SSc who experienced two spontaneous abortions before delivering a healthy baby after administration of vitamin E. Vitamin E is known to have properties of antioxidants and anti-platelet aggregation agents and may prevent placental ischemia induced by decidual vasculopathy [19].…”

Section: Medications During Pregnancymentioning

confidence: 99%

Pregnancy and Scleroderma

Gorgiard¹,

Bérezné²,

Mouthon³

2012

Systemic Sclerosis - An Update on the Aberrant Immune System and Clinical Features

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Current awareness: Pharmacoepidemiology and drug safety

2005

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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A case of successful pregnancy in a woman with systemic sclerosis treated with cyclosporin

Cited by 8 publications

References 3 publications

Calcineurin inhibitors in systemic sclerosis – a systematic literature review

Calcineurin inhibitors in systemic sclerosis – a systematic literature review

Pregnancy and Scleroderma

Current awareness: Pharmacoepidemiology and drug safety

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