A Case of Subcutaneous Phaeohyphomycosis Associated with Leprosy

Teixeira, Márcia M. R.; Assunção, Cláudia Barbosa; Gomes, Renata Rodrigues; Rocha-Silva, Fabiana; Figueiredo, Sônia Maria de; Teixeira, Elen Rose; Carneiro, Adriana S.; Júnior, Rogério J.M.B.; Vicente, Vânia A.; Caligiorne, Rachel Basques

doi:10.2174/1871526517666170530124905

Cited by 3 publications

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“…Immunosuppressed and elderly patients suffer from infections with E. dermatitidis most commonly in the form of phaeohyphomycosis, keratitis or chromoblastomycosis; 54 cases of phaeohyphomycosis have been described between 1934 and 2006 (Figure 2) [12,13]. Literature research on recent published case reports involving E. dermatitidis-caused infections revealed 20 new cases since 2007 in both, immunocompetent and -suppressed patients (Table 1) [21,[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51]. E. dermatitidis may also be a severe agent of pneumonia [12].…”

Section: E Dermatitidis Causing Phaeohyphomycosis In Immunosuppressed Patients and Fatal Infections In Immunocompetent Individualsmentioning

confidence: 99%

Exophiala dermatitidis: Key issues of an opportunistic fungal pathogen

et al. 2019

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The black yeast Exophiala dermatitidis is an opportunistic pathogen, causing phaeohyphomycosis in immunosuppressed patients, chromoblastomycosis and fatal infections of the central nervous system in otherwise healthy Asian patients. In addition, it is also regularly isolated from respiratory samples from cystic fibrosis patients, with rates varying between 1% and 19%.Melanin, as part of the cell wall of black yeasts, is one major factor known contributing to the pathogenicity of E. dermatitidis and increased resistance against host defense and anti-infective therapeutics. Further virulence factors, e.g. the capability to adhere to surfaces and to form biofilm were reported. A better understanding of the pathogenicity of E. dermatitidis is essential for the development of novel preventive and therapeutic strategies. In this review, the current knowledge of E. dermatitidis prevalence, clinical importance, diagnosis, microbiological characteristics, virulence attributes, susceptibility, and resistances as well as therapeutically strategies are discussed.

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