A case of stercoral colitis with marked elevation of serum carcinoembryonic antigen

Abstract

It should be noted that the serum CEA level can become elevated in severe stercoral colitis. Marked elevation of the serum CEA level in stercoral colitis may suggest the necessity of surgery in patients with stercoral colitis.

All-Dielectric Metasurface Fluorescence Biosensors for High-Sensitivity Antibody/Antigen Detection

“…Note that the target CEA is label-free. CEA is a cancer marker, currently used for medical diagnosis. − As the binding molecules, Cys-streptavidin was first immobilized on the metasurface of the SOI-nanorod array. Then, the reaction liquid, containing biotin-labeled anti-CEA Ab, CEA, and anti-CEA Ab without any label, was flowed through after a half-hour reaction at the room temperature (RT) of 299 K with shaking at 400 rpm.…”

“…To realize practical point-of-cure (POC) medical diagnosis, all-dielectric and plasmonic metasurfaces were coupled with microfluidic (MF) chips made of polydimethylsiloxane (PDMS). Cancer markers such as prostate specific antigen (PSA) and carcinoembryonic antigen (CEA) , were detected in human serum with a total operation time of 3–5 h; the all-dielectric metasurfaces detected the target PSA of more than 1 ng/mL, which satisfies a diagnosis criterion of 4 ng/mL, while the plasmonic metasurfaces detected the target CEA of more than 5 ng/mL, which needs an improvement in sensitivity to satisfy a diagnosis criterion of 5 ng/mL. − In the all-dielectric metasurfaces, , the limit of detection (LOD) of the target protein molecules by the resonant wavelength shift was approximately a few picomolars (pM) to tens of pM, taking into account the experimental configurations and conditions, whereas, in the plasmonic metasurfaces, , the LOD for CEA was approximately 30–60 pM. The LOD is less sensitive than that by commercially standard enzyme-linked immunosorbent assays (ELISA) that often claim to have a LOD of 1 pM or less; in the conventional ELISA, transmission at 450 nm is measured to evaluate the amount of enzyme products.…”

Non-perforated Stercoral Colitis patients with septic shock have a higher mortality than their perforated counterparts. A case report and review of literature

“…Within the individual case reports were 13 cases of PSC with 3 fatalities [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] . There were 9 cases total of NPSC with 4 fatalities [4] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] . When the NPSC cases were stratified for sepsis, a total of 4 cases with 2 fatalities was yielded [24] , [25] , [26] , [27] .…”

Robust Detection of Cancer Markers in Human Serums Using All-Dielectric Metasurface Biosensors

“…Human serums are most commonly examined for cancer markers in clinical examinations [ 3 , 4 , 5 ]. Accordingly, biosensors applicable to cancer markers were often tested for their robustness using human serums [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”