Abstract:Parasitic myoma (PM) is a rare disease in which multiple leiomyomas are intraperitoneally formed. Recently, an increasing number of cases due to specimen morcellation during minimally invasive surgery has been reported. We present the first case of a PM identified intraoperatively during laparoscopic hysterectomy. A 40 -yearold Japanese multiparous woman presented to our hospital with heavy menstrual bleeding. She had no history of previous surgery. Magnetic resonance imaging showed uterine myomas. As the pati… Show more
“…Pathogenesis of benign metastasising (or parasitic) ULs is barely studied. There are assumptions that UL metastases might occur as a complication after laparoscopic surgery due to the morcellation of myomas and even that UL metastasising points towards the underestimated malignant potential of the initial tumour [ 229 , 230 , 231 , 232 ]. Regardless of UL metastasising mechanism, this phenomenon raises the need to update UL classification criteria as well as criteria to distinguish benign and malignant tumours.…”
Section: Spectrum Of Somatic Genetic Aberrations In Ul Cellsmentioning
Uterine leiomyomas (ULs), frequent benign tumours of the female reproductive tract, are associated with a range of symptoms and significant morbidity. Despite extensive research, there is no consensus on essential points of UL initiation and development. The main reason for this is a pronounced inter- and intratumoral heterogeneity resulting from diverse and complicated mechanisms underlying UL pathobiology. In this review, we comprehensively analyse risk and protective factors for UL development, UL cellular composition, hormonal and paracrine signalling, epigenetic regulation and genetic abnormalities. We conclude the need to carefully update the concept of UL genesis in light of the current data. Staying within the framework of the existing hypotheses, we introduce a possible timeline for UL development and the associated key events—from potential prerequisites to the beginning of UL formation and the onset of driver and passenger changes.
“…Pathogenesis of benign metastasising (or parasitic) ULs is barely studied. There are assumptions that UL metastases might occur as a complication after laparoscopic surgery due to the morcellation of myomas and even that UL metastasising points towards the underestimated malignant potential of the initial tumour [ 229 , 230 , 231 , 232 ]. Regardless of UL metastasising mechanism, this phenomenon raises the need to update UL classification criteria as well as criteria to distinguish benign and malignant tumours.…”
Section: Spectrum Of Somatic Genetic Aberrations In Ul Cellsmentioning
Uterine leiomyomas (ULs), frequent benign tumours of the female reproductive tract, are associated with a range of symptoms and significant morbidity. Despite extensive research, there is no consensus on essential points of UL initiation and development. The main reason for this is a pronounced inter- and intratumoral heterogeneity resulting from diverse and complicated mechanisms underlying UL pathobiology. In this review, we comprehensively analyse risk and protective factors for UL development, UL cellular composition, hormonal and paracrine signalling, epigenetic regulation and genetic abnormalities. We conclude the need to carefully update the concept of UL genesis in light of the current data. Staying within the framework of the existing hypotheses, we introduce a possible timeline for UL development and the associated key events—from potential prerequisites to the beginning of UL formation and the onset of driver and passenger changes.
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